Laparoscopic finding of a hepatic subcapsular spider-like telangiectasis sign in biliary atresia

Table 1 Clinical characteristics of patients with biliary atresia, non-biliary atresia patients and control subjects in the retrospective study

Characteristic	BA (n = 72)	Non-BA (n = 54)	P value1	Control (n = 38)	P value2	P value3
Age (d)	58 ± 29 (20-180)	59 ± 21 (35-125)	0.89	63 ± 22 (36-109)	0.35	0.34
Male-to-female ratio	31:41	24:30	0.88	19:19	0.49	0.60
Total bilirubin (μmol/L)	197.6 ± 72.8	163.6 ± 62.1	0.062	19.3 ± 18.3	<0.0001	<0.0001
Direct bilirubin (μmol/L)	132.8 ± 143.8	99.3 ± 50.8	0.29	5.7 ± 5.6	0.003	<0.0001
ALT (U/L)	162.9 ± 122.6	170.2 ± 362.6	0.91	21.3 ± 7.4	<0.0001	0.15
AST (U/L)	239.7 ± 156.7	183.5 ± 253.1	0.27	30.0 ± 11.1	<0.0001	0.037
GGT(U/L)	684.7 ± 450.6	454.2 ± 450.9	0.052	46.5 ± 22.4	<0.0001	0.003

¹BA vs non-BA;

²BA vs controls;

³Non-BA vs controls. The results are expressed as the mean ± SD or number (percentage). HSST: Hepatic subcapsular spider-like telangiectasis; BA: Biliary atresia; ALT: Alanine aminotransferase; AST: Aspartate aminotransferase; GGT: Gamma-glutamyl transpeptidase.

Table 2 Diagnostic value of the hepatic subcapsular spider-like telangiectasis sign in first and consensus reviews by two reviewers in the retrospective study n (%)

	First review
	Observer 11		Observer 22		Consistent result
Imaging feature	Sensitivity	Specificity	Sensitivity	Specificity	Sensitivity	Specificity
HSST	72 (100)	54 (100)	72 (100)	53 (98.1)	72 (100)	53 (98.1)

¹Observer 1 = Zhou Ying;

²Observer 2 = Jiang Meng.

Table 3 Clinical characteristics of biliary atresia and non-biliary atresia patients in the validation group

Characteristic	BA (n = 45)	Non-BA (n = 45)	P value
Age (d)	60 ± 29	61 ± 23	0.90
Male-to-female ratio	21:24	25:20	0.40
Total bilirubin (μmol/L)	192.3 ± 63.5	173.6 ± 77.0	0.21
Direct bilirubin (μmol/L)	131.6 ± 140.8	104.5 ± 52.3	0.23
ALT (U/L)	172.8 ± 120.9	124.3 ± 264.1	0.27
AST (U/L)	255.2 ± 162.1	188.7 ± 193.9	0.08
GGT (U/L)	661.8 ± 466.3	320.7 ± 384.1	<0.001

The results are expressed as the mean ± SD. BA: Biliary atresia; ALT: Alanine aminotransferase; AST: Aspartate aminotransferase; GGT: Gamma-glutamyl transpeptidase.