Aberrant DNA-PKcs and ERGIC1 expression may be involved in initiation of gastric cancer

Table 1 Basic demographic data of the study subjects

Group	n	Age (range) (yr)	Male/female
Healthy	30	43 (38-51)	16/14
Mild dysplasia	30	54 (42-67)	22/18
Moderate dysplasia	30	58 (40-65)	14/16
Severe dysplasia	30	63 (43-76)	19/11
Gastric cancer	40	61 (39-68)	23/17

Table 2 Results of DNA-PKcs and ERGIC1 from proteomic analysis

Protein ID	Gene	Protein	Fold change
			Mild/normal	Moderate/normal	Severe/normal	Cancer/normal
P78527	PRKDC	DNA-dependent protein kinase catalytic subunit	1.12	1.54	1.60	2.30
Q969X5	ERGIC1	Endoplasmic reticulum-Golgi intermediate compartment protein 1	1.18	0.84	0.73	0.46

Table 3 Results of DNA-PKcs and ERGIC1 from immunohistochemistry

Group	n	DNA-PKcs				n	ERGIC1
		-	+	++	+++		-	+	++	+++
Normal	30	12	18	0	0	30	2	2	2	24
Mild	30	14	16	0	0	30	2	3	3	22
Moderate	30	5	3	23	0	30	2	3	25	0
Severe	30	3	2	25	0	30	5	5	20	0
Cancer	30	0	2	6	22	40	9	27	4	0