HOX transcript antisense intergenic RNA represses E-cadherin expression by binding to EZH2 in gastric cancer

Table 1 Relationships between the expression of HOTAIR and clinicopathological characteristics in 65 patients with gastric cancer

Characteristic	Expression of HOTAIR		P value
	Low n = 32	High n = 33
Sex			0.408
Female	7	11
Male	25	22
Age in yr			0.455
≤ 60	17	21
> 60	15	12
Histological grade			1.000
Well/moderate	14	15
Other	18	18
Tumor invasion depth, T			0.018
Tis, T1,T2	15	6
T3 or above	17	27
Lymph node metastasis, N			0.023
N0	12	4
N1 or above	20	29
TNM stage			0.024
I/II	23	14
III/IV	9	19
Tumor location			0.102
Antrum	8	15
Cardia	10	9
Angulus	13	5
Body	1	3
Full stomach	0	1
Laure’s classification			0.373
Intestinal	17	15
Diffuse	12	17
Mixed	3	1

Table 2 Univariate and multivariate analysis of clinical pathological characteristics and overall survival of 65 patients with gastric cancer

Factor	Univariate analysis			Multivariate analysis
	HR	95%CI	P value	HR	95%CI	P value
HOTAIR expression	2.943	1.580-5.483	0.001	1.998	1.058-3.772	0.033
Tumor invasion depth, T1, T2/above	2.651	1.316-5.341	0.006	1.676	0.691-4.067	0.254
Lymphatic metastasis, absent/present	3.470	1.459-8.250	0.005	4.324	1.701-10.993	0.002
TNM stage, I/II, III/IV	4.494	2.351-8.592	< 0.001	3.598	1.624-7.975	0.002
Histology grade, well, moderate/others	0.967	0.535-1.750	0.913
Age, < 60/> 60	0.730	0.396-1.344	0.312
Sex, male/female	0.822	0.428-1.581	0.557
Tumor location	0.839	0.623-1.131	0.250
Lauren’s classification	1.256	0.757-2.084	0.378