Editorial
Copyright ©The Author(s) 2017.
World J Gastroenterol. Aug 28, 2017; 23(32): 5829-5835
Published online Aug 28, 2017. doi: 10.3748/wjg.v23.i32.5829
Table 1 Role of adipocyte secreted factors and metabolites and signalling pathways
AT secreted factorsFunctionSignalling pathwayRef.
TNF-αPro-inflammatory,PI3K, NF-κBPikarsky et al[17], 2004
cell proliferation, anti-apoptotic, angiogeneticHuang et al[18], 2009
Viatour et al[19], 2005
IL-6Pro-inflammatory, cell proliferation and anti- apoptoticJAK/STAT3Hodge DR et al[20], 2005
LeptinPromotion of cell survival, proliferation, differentiation, pro-inflammatoryJAK/STAT, PI3K, MAPKHefetz-Sela et al[22], 2013
Hoda et al[23], 2007
AdiponectinAnti-inflammatory, anti-proliferative and pro-apoptotic effectInhibition of PI3K, AMPK/mTOR, JAK/STAT3, NF-κBHefetz-Sela et al[22], 2013
VisfatinPro-inflammatory, angiogenic, promotion of cell survival and migrationERK/MAPK, PI3K/AKT, NF-κB, β1-integrinAdya et al[25], 2008
Huang et al[26], 2013
Lipid peroxidation productsPromotion of cell proliferation, differentiation, survival, migration, angiogenesisPI3K/AKT/mTORAyala et al[27], 2014
NF-κB, PPAR, MAPK