Copyright
©The Author(s) 2017.
World J Gastroenterol. Aug 21, 2017; 23(31): 5650-5668
Published online Aug 21, 2017. doi: 10.3748/wjg.v23.i31.5650
Published online Aug 21, 2017. doi: 10.3748/wjg.v23.i31.5650
Ref. | HCC patients | Ethnicity | Background liver status | Patient background | Controls | Methodology | Positive rate |
Matsumura, et al[51], 1999 | 88 | Japan | HCV: 85%, HBV: 6% | Pre and post (TAE or PEI) | NA | RT-PCR (AFP) | 63.0% |
Mou et al[56], 2002 | 30 | China | HBV: 100% | Pre resection | 25 (HV: 25) | RT-PCR (MAGE1/3) | 43.3% |
LC: 100% | |||||||
Witzigmann et al[55], 2002 | 85 | Germany | NA | Pre, during, post (Resection: 24, LT: 10, TACE: 13, No treatment: 38) | 116 ( OLT: 50, HD: 39, HV: 27) | RT-PCR (AFP) | 28.0% |
Vona et al[31], 2004 | 44 | France | LC: 89% | Pre/post resection: 22 | 107 (HV: 38, HD: 69) | ISET | 52.2% |
Unresectable: 22 | |||||||
Jeng et al[53], 2004 | 81 | China | HBV: 77%, HCV: 38% | Pre and post resection | 50 (HV: 30, HD: 20) | RT-PCR (AFP) | 23.4% |
LC: 69% | |||||||
Cillo et al[52], 2004 | 50 | Italy | HCV: 50%,HBV: 12% | Pre (Resection: 17, LT: 9, PT: 17) | 50 (HD: 6, OT: 44) | RT-PCR (AFP) | 40.0% |
HCV and HBV: 6% | |||||||
Alcohol: 10% | No treatment: 7 | ||||||
LC: 84% | |||||||
Kong et al[59], 2009 | 343 | South Korea | HBV: 78%, HCV: 10% | Pre (Resection: 12, TACE: 224, RFA: 44, Chemotherapy: 12, Radiotherapy: 12, No treatment: 39) | NA | RT-PCR (AFP) | |
Alcohol: 6% | (hTERT) | 59.5% | |||||
LC: 52% | 14.0% | ||||||
Fan et al[69], 2011 | 82 | China | HBV: 80% | Pre and post resection | NA | CellSearchTM | 68.3% |
Xu et al[70], 2011 | 85 | China | HBV: 84%, HCV: 7% | Pre Resection: 63 | 71 (HD: 37, HV: 20, OT: 14) | CellSearchTM | 81.0% |
HBV and HCV: 5% | Clinical Diagnosis: 22 | ||||||
nonB, nonC: 4% | |||||||
Liu et al[67], 2013 | 60 | China | HBV: 93% | Pre resection | NA | Flow cytometry | 50.0% |
LC: 93% | |||||||
Yao et al[57], 2013 | 123 | China | HBV: 72% | NA | 276 (HV: 30, HD: 196, OT: 50) | RT-PCR (GPC-3) | 70.77% |
LC: 93% | |||||||
Sun et al[73], 2013 | 123 | China | HBV: 75% | Pre/post resection | NA | CellSearchTM | 66.6% |
LC: 76% | |||||||
Schulze et al[72], 2013 | 59 | Germany | Alcohol: 38% | Pre (resection or systemic therapy) | 19 (HD: 19) | CellSearchTM | 30.5% |
HBV: 17%, HCV: 13% | |||||||
LC: 89% | |||||||
Li et al[71], 2013 | 60 | China | HBV: 92%, HCV: 3% | NA | 30 (HD: 10, HV: 10, OT: 10) | CellSearchTM | 76.6% |
nonB, nonC: 7% | |||||||
LC: 88.7% | |||||||
Bahnassy et al[68], 2014 | 70 | Egypt | HCV: 100% | NA | 63 (HD: 30, HV: 33) | Flow cytometry (CK19, CD90, 133) | 73.0%, 49.8%, 69.5% |
RT-PCR (Telomerase, MAGE1/3) | 55.7%, 60.0%, 62.9% | ||||||
Li et al[76], 2014 | 27 | China | NA | NA | 61 (HD: 34, HV: 15, OT: 12) | CellSearchTM | 88.9% |
Mu et al[78], 2014 | 62 | China | HBV: 95.2% | NA | 22 (HD: 7, HV: 15) | CellSearchTM | 48.3% |
Fang et al[74], 2014 | 42 | China | LC: 55% | Pre and post TACE | 20 (HV: 10, HD: 10) | CellSearchTM | 52.3% |
Morris et al[77], 2014 | 52 | United Kingdom | Alcohol: 38%, | No treatment | NA | CellSearchTM | 28% |
HBV: 8% | ISET | 100% | |||||
Diabetes: 12% | |||||||
Guo et al[75], 2014 | 299 | China | HBV: 90% | Pre/post (Resection: 157, TACE: 76, RFA: 66) | 120 (HV: 71, HD: 25, BT: 24) | CellSearchTM | 42.6% |
LC: 90% | |||||||
Choi et al[58], 2015 | 81 | South Korea | HBV: 80%, HCV: 11% | Pre and post (Resection: 64, LT: 17) | 16 (LHD: 16) | RT-PCR (K19, CD44) | 22.2% |
Alcohol: 4% | |||||||
LC: 59% | |||||||
Kelley et al[19], 2015 | 20 | Caucasian: 55%, | HBV: 25%, HCV: 45% | NA | 10 (HD: 10) | CellSearchTM | 40.0% |
Asian: 35%, | HBV and HCV: 10% | ||||||
American: 10% | Alcohol: 5% | ||||||
(African-5%) | NAFLD: 10% | ||||||
(Native-5%) | |||||||
Wang et al[79], 2016 | 42 | China | HBV: 81%, HCV: 2% | NA | NA | CTC-Chip | 59.5% |
nonB, nonC: 17% | |||||||
Zhang et al[207], 2016 | 36 | China | NA | NA | NA | CTC-Chip | 100% |
Ref | HCC patients | Sample | Ethnicity | Background liver | Controls | cfDNA abnormalities | Target |
Methodolgy | |||||||
Wong et al[105], 2000 | 25 | Plasma/serum | Hong-Kong | HBV: 88% | 55 (HD: 35, HV: 20) | Methylation | P16 |
15 | Buffy coat | HCV: 2% | 35 (HD: 15, HV: 20) | MS-PCR | |||
Wong et al[108], 2003 | 29/22 | Plasma/serum | Hong Kong | NA | 50 (HD and HV) | Methylation | P16INK4A |
29 | Buffy coat | 35 (HD: 15, HV: 20) | MS-PCR | ||||
Chu et al[109], 2004 | 46 | Serum | Korea | HBV: 65% | 23 (HD: 23) | Methylation | P16INK4A |
HCV: 22% | MS-PCR | ||||||
Yeo et al[110], 2005 | 40 | Plasma | Hong-Kong | HBV: 83% | 10 (HV: 10) | Methylation | RASSF1A |
MS-PCR | |||||||
Iizuka et al[96], 2006 | 52 | Serum | Japan | HCV: 100% | 46 (HD: 30, HV: 16) | Quantitative analysis | GSTP1 |
Real-time PCR | |||||||
Ren et al[97], 2006 | 79 | Plasma | China | HBV: 85% LC: 86% | 40 (HD: 20, HV: 20) | Quantitative analysis | NA |
Real-time PCR | |||||||
Allelic imbalance analysis | D8S258 and D8S264 | ||||||
Zhang et al[112], 2007 | 50 | Serum | Taiwan | HBV: 22% | 50 | Methylation | P15, P16 |
HCV: 16% | HV: 50 | MS-PCR | |||||
Tan et al[111], 2007 | 8 | Serum | Singapore | NA | 72 (OT: 62, HV: 10) | Methylation | RUNX3 |
MS-PCR | |||||||
Chan et al[113], 2008 | 85 | Serum | Hong-Kong | HBV: 92% | 135 (HD: 63, HV: 72) | Methylation | RASSFIA |
RT-PCR | |||||||
Chang et al[114], 2008 | 19 | Plasma | China | HBV: 89% | 17 (LC: 17) | Methylation | APC, GSTP1, RASSF1A, P16, E-cadherin |
MS-PCR | |||||||
Iyer et al[115], 2010 | 28 | Plasma | Egypt | HCV: 79% | NA | Methylation | APC, FHIT, P15, P16 and E-cadherin |
HNV: 18% | MS-PCR | ||||||
Yang et al[98], 2011 | 60 | Plasma | China | NA | 50 (HD: 21, HV: 29) | Quantitative analysis | hTERT |
FQ-PCR | |||||||
Szymañska et al[103], 2011 | 14 | Plasma | China | Mostly HBV | NA | Single nucleotide mutation | R249S (TP53 mutation) |
SOMA | |||||||
Iizuka et al[117], 2011 | 220 | Serum | Japan | HCV: 100% | 202 (HD: 202) | Methylation | SPINT2, SRD5A2 |
MS-PCR | |||||||
Huang et al[116], 2011 | 72 | Plasma | China | HBV: 85% | 37 (HD: 37) | Methylation | APC, GSTP1, RASSF1A, and SFRP1 |
MSRE-qPCR | |||||||
Huang et al[100], 2012 | 72 | Plasma | China | HBV: 85% | 115 (HD: 74, HV: 41) | Quantitative analysis | NA |
Real-time PCR | |||||||
Chen et al[99], 2012 | 80 | Serum | China | HBV: 100% | 130 (HD: 80, HV: 50) | Quantitative analysis | NA |
Real-time PCR | |||||||
Mohamed et al[118], 2012 | 40 | Serum | Egypt | HCV: 100% | 60 (HD: 40, HV: 20) | Methylation | RASSF1A |
Real-time PCR | |||||||
Chen et al[101], 2013 | 39 | Serum | China | HBV: 79% | 45 (HV: 45) | Quantitative analysis | NA |
Real-time PCR | |||||||
Piciocchi et al[102], 2013 | 66 | Plasma | Italy | HCV: 51% | 76 (HD: 76) | Quantitative analysis | hTERT |
Alcohol: 27% | Real-time PCR | ||||||
Chan et al[95], 2013 | 4 | Plasma | China | NA | 20 (HD: 4, HV: 16) | Copy number variation | NA |
MPS | |||||||
Sun et al[119], 2013 | 43 | Serum | China | HBV: 86% | 50 (HD: 24, HV: 26) | Methylation | TFPI2 |
MS-PCR | |||||||
Zhang et al[120], 2013 | 37 | Serum | China | HBV: 100% | 33 (HD: 33) | Methylation | DBX2, THY1 |
Bead Chip, Hot-start PCR, Pyrosequencing | |||||||
Huang et al[122], 2014 | 66 | Serum | United States | HCV: 100% | 43 (HD: 43) | Methylation | INK4A |
HCV and HBV: 6% | Pyrosequencing, MS-PCR | ||||||
Han et al[121], 2014 | 160 | Serum | China | HBV: 22% | 133 (HD: 88, HV: 45) | Methylation | TRG5 |
MS-PCR | |||||||
Ji et al[123], 2014 | 121 | Serum | China | HBV: 83% | 68 (HD: 37, HV: 31) | Methylation | MT1M |
MS-PCR | |||||||
Kuo et al[124], 2014 | 40 | Plasma | Taiwan | NA | 34 | Methylation | HOXA9 |
MS-PCR | |||||||
Jiang et al[104], 2015 | 90 | Plasma | Hong-Kong | NA | 135 (HD: 103, HV: 32) | Copy number variation | NA |
CAZA |
miR | Expression | Sample | HCC patients | Ethnicity | Background liver | Controls | Value | Ref. |
miR-1 | Up | Serum | 195 | Germany | HCV: 45%, Alcohol: 33%, HBV: 17% | 54 (HD: 54) | P | Köberle et al[155] 2013 |
miR-10b | Up | Blood | 27 | China | Alcohol: 23% | 81 (HD: 81) | D | Jiang et al[175] 2015 |
miR-15b | Up | Serum | 153 | China | HBV: 88% | 59 (HD: 29, HV: 39) | D | Liu et al[152] 2012 |
miR-15b-5p | Down | Plasma | 37 | China | NA | 60 (HD: 29, HV: 31) | D | Chen et al[170] 2015 |
miR-16 | Down | Serum | 105 | United States | HCV: 64%, HBV: 20% | 178 (HD: 107, HV: 7) | D | Qu et al[148] 2011 |
90 | China | NA | 60 (HV: 60) | D | Ge et al[161] 2014 | |||
40 | Egypt | HCV: 100% | 60 (HD: 40, HV: 20) | D | El-Abd et al[174] 2015 | |||
miR-17-5p | Up | Serum | 136 | China | NA | NA | P | Zheng et al[159] 2013 |
8 | Turkey | HCV: 100% | 84 (HD: 56, HV: 28) | D | Oksuz et al[178] 2015 | |||
miR-18a | Up | Serum | 101 | China | HBV: 100% | 90 (HD: 30, HV: 60) | D | Li et al[151] 2012 |
Up | Serum | 20 | South Korea | HBV: 70% | 40 (HD: 40) | D | Sohn et al[179] 2015 | |
miR-19a | Down | Serum | 112 | Egypt | HCV: 100% | 167 (HD: 125, HV: 42) | D | Motawi et al[177] 2015 |
miR-21 | Up | Plasma | 457 | China | HBV:100% | 477 (HD: 310, HV: 167) | D | Zhou et al[150] 2011 |
136 | Japan | HCV:68%, HBV: 23% | 80 (HD: 30, HV: 50) | D, P | Tomimaru et al[153] 2012 | |||
Serum | 101 | China | HBV: 75% | 137 (HD: 48, HV: 89) | D | Xu et al[149] 2011 | ||
136 | China | HBV: 95% | NA | P | Liu et al[164] 2014 | |||
97 | China | HBV: 62% | 30 (HV: 30) | D, P | Wang et al[180] 2015 | |||
23 | Egypt | HCV: 87%, HBV: 13% | 17 (HD: 17) | D | Amr et al[186] 2016 | |||
Down | Serum | 70 | China | HBV: 100% | 72 (HD 48, HV: 24) | D | Qi et al[147] 2011 | |
90 | China | NA | 60 (HV: 60) | D, P | Ge et al[161] 2014 | |||
52 | China | HBV: 63%, HCV: 4% | 85 (HD: 42, HV: 43) | D | Zhuang et al[195] 2016 | |||
miR-22 | Down | Serum | 192 | Egypt | HCV: 100% | 192 (HD: 192) | D | Zekri et al[194] 2016 |
miR-24-3p | Up | Serum | 84 | China | HBV: 100% | 77 (HD: 31, HV: 46) | D, P | Meng et al[165] 2014 |
miR-26a | Down | Plasma | 457 | China | HBV: 100% | 477 (HD: 310, HV: 167) | D | Zhou et al[150] 2011 |
Serum | 52 | China | HBV: 63%, HCV: 4% | 85 (HD42, HV: 43) | D | Zhuang et al[195] 2016 | ||
miR-26a-5p | Down | Serum | 261 | China | HBV: 100% | 406 (HD 233, HV: 173) | D | Tan et al[166] 2014 |
miR-27a | Down | Plasma | 457 | China | HBV: 100% | 477 (HD: 310, HV: 167) | D | Zhou et al[150] 2011 |
miR-29b | Down | Serum | 192 | Egypt | HCV: 100% | 192 (HD: 192) | D | Zekri et al[194] 2016 |
miR-30c | Down | Serum | 242 | China | HCV: 63% | NA | P | Liu et al[176] 2015 |
miR-30c-5p | Down | Serum | 8 | Turkey | HCV: 100% | 84 (HD: 56, HV: 28) | D | Oksuz et al[178] 2015 |
miR-34a | Up | Serum | 112 | Egypt | HCV: 100% | 167 (HD: 125, HV: 42) | D | Motawi et al[177] 2015 |
miR-92a-3p | Up | Plasma | 20 | Turkey | HBV: 100% | 74 (HD: 46, HV: 28) | D | Giray et al[162] 2014 |
miR-96 | Up | Serum | 104 | China | HBV: 100% | 400 (HD: 280, HV: 120) | D | Chen et al[171] 2015 |
miR-101 | Up | Serum | 25 | China | HBV: 100% | 20 (HV: 20) | D | Fu et al[154] 2013 |
Down | Serum | 67 | China | HBV: 100% | 170 (HD: 140, HV: 3,) | D | Xie et al[167] 2014 | |
20 | South Korea | HBV: 70% | 40 (HD: 40) | D | Sohn et al[179] 2015 | |||
52 | China | HBV: 63%, HCV: 4% | 85 (HD: 42, HV: 43) | D | Zhuang et al[195] 2016 | |||
miR-106b | Up | Blood | 27 | China | Alcohol: 23% | 81 (HD: 31, HV: 50,) | D | Jiang et al[175] 2015 |
miR-122 | Up | Serum | 70 | China | HBV: 100% | 72 (HD: 48, HV: 24,) | D | Qi et al[147] 2011 |
101 | China | HBV: 75% | 137 (HD: 48, HV: 89,) | D | Xu et al[149] 2011 | |||
195 | Germany | HCV: 45%, Alcohol: 33%, HBV: 17% | 54 (HD: 54) | P | Köberle et al[155] 2013 | |||
30 | Egypt | HCV: 100% | 70 (HD: 60, HV: 10) | D | El-Garem et al[160] 2014 | |||
136 | China | HBV: 95% | NA | P | Liu et al[164] 2014 | |||
192 | Egypt | HCV: 100% | 192 (HD: 192) | D | Zekri et al[194] 2016 | |||
Down | Plasma | 457 | China | HBV: 100% | 477 (HD: 310, HV: 167) | D | Zhou et al[150] 2011 | |
Serum | 20 | South Korea | HBV: 70% | 40 (HD: 40) | D | Sohn et al[179] 2015 | ||
122 | China | NA | NA | P | Xu et al[181] 2015 | |||
miR-122a | Down | Serum | 85 | China | HBV: 88% | HV (HV: 85) | D | Luo et al[156] 2013 |
miR-122-5p | Up | Plasma | 20 | Turkey | HBV: 100% | 74 (HD: 46, HV: 28) | D | Giray et al[162] 2014 |
Plasma | 120 | South Korea | HBV: 100% | NA | P | Cho et al[172] 2015 | ||
Serum | 120 | China | HBV: 100% | DN: 30 | D | Hung et al[189] 2016 | ||
Down | Serum | 261 | China | HBV: 100% | 406 (HD: 233, HV: 173) | D | Tan et al[166] 2014 | |
miR-125b | Down | Plasma | 64 | China | HBV: 100% | 178 (HD: 122, HV: 56) | D | Chen et al[187] 2016 |
miR-125b-5p | Up | Plasma | 20 | Turkey | HBV: 100% | 74 (HD: 46, HV: 28) | D | Giray et al[162] 2014 |
miR-126 | Up | Plasma | 59 | India | HBV: 100% | 38 (HD: 20, HV: 18) | D | Ghosh et al[188] 2016 |
Down | Serum | 23 | Egypt | HCV: 100% | 55 (HD: 55) | D | Khairy et al[190] 2016 | |
miR-128-2 | Up | Serum | 222 | China | HBV: 87% | NA | P | Zhuang et al[184] 2015 |
miR-129 | Down | Serum | 23 | Egypt | HCV: 100% | 55 (HD: 55) | D | Khairy et al[190] 2016 |
miR-130a | Up | Serum | 112 | Egypt | HCV: 100% | 167 (HD: 125, HV: 42) | D | Motawi et al[177] 2015 |
miR-130b | Up | Serum | 153 | China | HBV: 88% | 59 (HD: 29, HV: 30) | D | Liu et al[152] 2012 |
miR-139 | Down | Plasma | 31 | China | NA | 31 (HD: 31) | D, P | Li et al[163] 2014 |
miR-141-3p | Up | Serum | 261 | China | HBV: 100% | 406 (HD: 233, HV: 173) | D | Tan et al[166] 2014 |
miR-143 | Up | Serum | 95 | China | NA | 245 (HD: 118, HV: 127) | D | Zhang et al[168] 2014 |
miR-143-3p | Up | Plasma | 59 | India | HBV: 100% | 38 (HD: 20, HV: 18) | D | Ghosh et al[188] 2016 |
miR-146a | Up | Serum | 112 | Egypt | HCV: 100% | 167 (HD: 125, HV: 42) | D | Motawi et al[177] 2015 |
miR-150 | Down | Serum | 120 | China | HBV: 100% | 230 (HD: 110, HV: 120) | D, P | Yu et al[183] 2015 |
miR-155 | Down | Serum | 23 | Egypt | HCV: 100% | 55 (HD: 55) | D | Khairy et al[190] 2016 |
miR-181a | Down | Blood | 27 | China | Alcohol: 23% | 81 (HD: 31, HV: 50) | D | Jiang et al[75] 2015 |
miR-181b | Up | Serum | 192 | Egypt | HCV: 100% | 192 (HD: 192) | D | Zekr et al[194] 2016 |
miR-182 | Up | Serum | 103 | China | NA | 135 (HD: 95, HV: 40) | D, P | Chen et al[169] 2015 |
miR-192 | Up | Plasma | 457 | China | HBV: 100% | 477 (HD: 310, HV: 167) | D | Zhou et al[150] 2011 |
Serum | 112 | Egypt | HCV: 100% | 167 (HD: 125, HV: 42) | D | Motawi et al[177] 2015 | ||
miR-192-5p | Down | Serum | 261 | China | HBV: 100% | 406 (HD: 233, HV: 173) | D | Tan et al[166] 2014 |
miR-195 | Down | Serum | 112 | Egypt | HCV: 100% | 167 (HD: 125, HV: 42) | D | Motawi et al[177] 2015 |
20 | South Korea | HBV: 70% | 40 (HD: 40) | D | Sohn et al[179] 2015 | |||
miR-199a | Down | Serum | 105 | United States | HCV: 64%, HBV: 20% | 178 (HD: 107, HV: 71) | D | Qu et al[148] 2011 |
40 | Egypt | HCV: 100% | 60 (HD: 40, HV: 20) | D, P | El-Abd et al[174] 2015 | |||
78 | China | NA | 156 (HV: 156) | D | Yin et al[182] 2015 | |||
23 | Egypt | HCV: 87%, HBV: 13% | 17 (HD: 17) | D | Amr et al[186] 2016 | |||
miR-199a-3p | Down | Serum | 192 | Egypt | HCV: 100% | 192 (HD: 192) | D | Zekri et al[194] 2016 |
miR-199a-5p | Down | Serum | 261 | China | HBV: 100% | 406 (HD: 233, HV: 173) | D | Tan et al[166] 2014 |
miR-200a | Up | Serum | 136 | China | HBV: 95% | NA | P | Liu et al[176] 2015 |
miR-203 | Down | Serum | 23 | Egypt | HCV: 100% | 55 (HD: 55) | D | Khairy et al[190] 2016 |
miR-203a | Down | Serum | 242 | China | HCV: 63% | NA | P | Liu et al[176] 2015 |
miR-206 | Up | Serum | 261 | China | HBV: 100% | 406 (HD: 233, HV: 173) | D | Tan et al[166] 2014 |
miR-215 | Up | Serum | 95 | China | NA | 245 (HD: 118, HV: 127) | D | Zhang et al[168] 2014 |
miR-218 | Down | Serum | 156 | China | HBV: 72% | 162 (HD: 98, HV: 64) | D, P | Yang et al[193] 2016 |
miR-221 | Up | Serum | 20 | South Korea | HBV: 70% | 40 (HD: 40) | D | Sohn et al[179] 2015 |
192 | Egypt | HCV: 100% | 192 (HD: 192) | D | Zekri et al[194] 2016 | |||
Down | Serum | 30 | Egypt | HCV: 100% | 70 (HD: 60, HV: 10) | D | El-Garem et al[174] 2014 | |
miR-222 | Up | Serum | 70 | China | HBV: 100% | 72 (HD: 48, HV: 24) | D | Qi et al[147] 2011 |
20 | South Korea | HBV: 70% | 40 (HD: 40) | D | Sohn et al[179] 2015 | |||
miR-223 | Up | Serum | 70 | China | HBV: 100% | 72 (HD: 48, HV: 24) | Qi et al[147] 2011 | |
Serum | 101 | China | HBV: 75% | 137 (HD: 48, HV: 89) | D | Xu et al[149] 2011 | ||
Down | Plasma | 457 | China | HBV: 100% | 477 (HD: 310, HV: 167) | D | Zhou et al[150] 2011 | |
Serum | 23 | Egypt | HCV: 100% | 55 (HD: 55) | D | Khairy et al[190] 2016 | ||
miR-223-3p | Down | Plasma | 20 | Turkey | HBV: 100% | 74 (HD: 46, HV: 28) | D | Giray et al[162] 2014 |
Serum | 8 | Turkey | HCV: 100% | 84 (HD: 56, HV: 28) | D | Oksuz et al[178] 2015 | ||
miR-224 | Up | Plasma | 107 | Japan | HCV: 41%, HBV: 18%, Alcohol: 15% | 102 (HD: 27, HV: 75) | D, P, T | Okajima et al[192] 2016 |
Serum | 20 | South Korea | HBV: 70% | 40 (HD: 40) | D | Sohn et al[179] 2015 | ||
182 | China | HBV: 87% | NA | D, P | Zhuang et al[185] 2015 | |||
122 | China | HBV: 100% | 157 (HD: 135, HV: 22) | D | Lin et al[191] 2016 | |||
miR-224-5p | Up | Serum | 136 | China | HBV: 95% | NA | P | Liu et al[164] 2014 |
miR-296 | Up | Serum | 112 | Egypt | HCV: 100% | 167 (HD: 125, HV: 42) | D | Motawi et al[177] 2015 |
miR-302c-3p | Down | Serum | 8 | Turkey | HCV: 100% | 84 (HD: 56, HV: 28,) | D | Oksuz et al[178] 2015 |
miR-331-3p | Up | Serum | 103 | China | NA | 135 (HD: 95, HV: 40) | D, P | Chen et al[169] 2015 |
miR-335 | Down | Serum | 125 | China | NA | 250 (HD: 125, HV: 125) | D, P | Cui et al[173] 2015 |
miR-338-5p | Up | Plasma | 37 | China | NA | 60 (HD: 29, HV: 31) | D | Chen et al[170] 2015 |
miR-375 | Up | Serum | 120 | China | HBV: 100% | 393 (HD: 183, HV: 210) | D | Li et al[145] 2010, |
Down | 78 | China | NA | 156 (HV: 156) | D | Yin et al[182] 2015. | ||
miR-433-3p | Up | Serum | 261 | China | HBV: 100% | 406 (HD: 233, HV: 173) | D | Tan et al[166] 2014 |
miR-483-5p | Up | Serum | 69 | United States | HCV: 63%, HBV: 14% | 69 (HV: 69) | D | Shen et al[157] 2013 |
112 | China | NA | 141 (HD: 56, HV: 85) | D | Zhang et al[158] 2013 | |||
miR-500a | Up | Serum | 112 | China | NA | 141 (HD: 56, HV: 85) | D | Zhang et al[158] 2013 |
miR-764 | Up | Plasma | 37 | China | NA | 60 (HD: 29, HV: 31) | D | Chen et al[170] 2015 |
miR-801 | Up | Plasma | 457 | China | HBV: 100% | 477 (HD: 310, HV: 167) | D | Zhou et al[150] 2011 |
miR-885-5p | Up | Serum | 46 | China | HBV: 72% | 105 (HD: 64, HV: 24, GC: 17) | D | Gui et al[146] 2011 |
192 | Egypt | HCV: 100% | 192 (HD: 192) | D | Zekri et al[194] 2016 | |||
miR-1228-5p | Up | Serum | 261 | China | HBV: 100% | 406 (HD: 233, HV: 173) | D | Tan et al[166] 2014 |
let-7b | Up | Serum | 120 | China | HBV: 100% | 30 (DN: 30) | D | Hung et al[189] 2016 |
let-7f | Down | Serum | 90 | China | NA | 60 (HV: 60) | D, P | Ge et al[161] 2014 |
- Citation: Okajima W, Komatsu S, Ichikawa D, Miyamae M, Ohashi T, Imamura T, Kiuchi J, Nishibeppu K, Arita T, Konishi H, Shiozaki A, Morimura R, Ikoma H, Okamoto K, Otsuji E. Liquid biopsy in patients with hepatocellular carcinoma: Circulating tumor cells and cell-free nucleic acids. World J Gastroenterol 2017; 23(31): 5650-5668
- URL: https://www.wjgnet.com/1007-9327/full/v23/i31/5650.htm
- DOI: https://dx.doi.org/10.3748/wjg.v23.i31.5650