Copyright
©The Author(s) 2017.
World J Gastroenterol. Aug 7, 2017; 23(29): 5431-5437
Published online Aug 7, 2017. doi: 10.3748/wjg.v23.i29.5431
Published online Aug 7, 2017. doi: 10.3748/wjg.v23.i29.5431
Table 1 Characteristics among patients with isolated organ failure, multiple organ failure, and no persistent organ failure
IOF | MOF | P value | No OF | P value | |
n = 43 | n = 68 | n = 389 | |||
Mean age ± SD | 50.7 (18.5) | 56.4 (15.4) | 0.08 | 50.5 ± 18.9 | 0.97 |
Male | 29 (67.4) | 46 (67.6) | 0.98 | 178 (45.8) | 0.007 |
Caucasian | 39 (90.7) | 61 (89.7) | 0.87 | 344 (88.4) | 0.66 |
Median BMI (IQR) | 28.8 (25.7-32.9) | 32.2 (28.7-36.4) | 0.009 | 27.5 (24.2-32.9) | 0.27 |
Transfers | 35 (81.4) | 61 (89.7) | 0.21 | 168 (43.2) | < 0.001 |
First episode of AP | 35 (81.4) | 58 (85.3) | 0.59 | 233 (59.9) | 0.006 |
Etiology | |||||
Biliary | 17 (39.5) | 35 (51.5) | 0.33 | 144 (37) | 0.03 |
Alcoholic | 12 (27.9) | 8 (11.8) | 51 (13.1) | ||
Idiopathic | 4 (9.3) | 9 (13.2) | 77 (19.8) | ||
Hypertriglyceridemia | 4 (9.3) | 9 (13.2) | 26 (6.7) | ||
Post-ERCP | 2 (4.7) | 3 (4.4) | 63 (16.2) | ||
Other | 4 (9.3) | 4 (5.9) | 28 (7.2) | ||
Comorbidities | |||||
Pre-existing heart failure | 0 | 2 (2.9) | 0.26 | 9 (2.3) | 0.31 |
Pre-existing renal failure | 1 (2.3) | 4 (5.9) | 0.38 | 8 (2.1) | 0.9 |
Pre-existing respiratory disorder | 2 (4.7) | 1 (1.5) | 0.31 | 16 (4.1) | 0.87 |
Table 2 Severity predictors, imaging findings, and clinical outcomes among acute pancreatitis patients with isolated organ failure, multi-organ failure, and no persistent organ failure n (%)
IOF | MOF | P value | No OF | P value | |
n = 43 | n = 68 | n = 389 | |||
SIRS score on admission ≥ 2 | 23 (53.5) | 45 (66.2) | 0.18 | 107 (27.5) | < 0.001 |
SIRS score at 48 h of admission ≥ 2 | 26 (60.5) | 52 (76.5) | 0.07 | 84 (21.6) | < 0.001 |
Mean IVF the first 24 h in liters (SD) | 4.38 (1.98) | 5.04 (1.79) | 0.41 | 3.79 (1.5) | 0.23 |
ICU admission | 36 (83.7) | 68 (100) | 0.001 | 50 (12.9) | < 0.001 |
Median ICU LOS in days (IQR) | 6 (2-14.4) | 18.5 (10-35) | < 0.001 | 0 | < 0.001 |
Need for nutritional support | 38 (88.4) | 58 (85.3) | 0.64 | 80 (20.6) | < 0.001 |
Pancreatic necrosis1 | 28/39 (71.8) | 45/54 (83.3) | 0.18 | 80/251 (31.9) | < 0.001 |
Infected necrosis1 | 5/39 (12.8) | 21/54 (38.9) | 0.006 | 11/164 (6.7) | 0.2 |
Need for drainage or debridement | 13 (30.2) | 38 (55.9) | 0.008 | 31 (8) | < 0.001 |
Extra-pancreatic infections | 8 (18.6) | 30 (44.1) | 0.006 | 27 (6.9) | 0.008 |
Median LOS in days (IQR) | 20 (16-32) | 37 (25-53) | < 0.001 | 6 (4-9) | < 0.001 |
Mortality | 0 | 22 (32.4) | < 0.001 | 0 |
Table 3 Demographics and clinical outcomes in severe acute pancreatitis patients with isolated renal failure and isolated respiratory failure n (%)
Isolated renal failure | Isolated respiratory failure | P value | |
n = 17 | n = 25 | ||
Male | 13 (76.5) | 16 (64) | 0.39 |
Mean ± SD | 56.1 (18.2) | 47.1 (18.6) | 0.13 |
Mean BMI (SD) | 32 (7.3) | 28.5 (4.8) | 0.06 |
Biliary etiology | 6 (35.3) | 11 (44) | 0.57 |
ICU admission | 10 (58.8) | 25 (100) | < 0.001 |
Mean ICU LOS in days (SD) | 2.4 (3.1) | 15.7 (12.7) | < 0.001 |
Need for nutritional support | 13 (76.5) | 24 (96) | 0.01 |
Pancreatic necrosis | 11 (64.7) | 16 (64) | 0.8 |
Need for drainage or debridement | 5 (29.4) | 7 (28) | 0.92 |
Median LOS (IQR) | 19 (15-28) | 22 (16-35) | 0.31 |
Mortality | 0 | 0 |
Table 4 Specific clinical parameters of patients with isolated renal failure
Patient | Age | Gender | Etiology | Comorbidity | PNec | Peak Cr | Dialysis | Dialysis at DC | Dialysis indication | ICU | LOS |
1 | 50 | M | Post-ERCP | Cirrhosis | No | 2.9 | No | NA | NA | No | 19 |
2 | 54 | M | HTG | None | No | 2.6 | No | NA | NA | No | 18 |
3 | 68 | M | Idiopathic | Diabetes | Yes | 2 | No | NA | NA | Yes | 19 |
4 | 64 | M | Biliary | Diabetes | Yes | 3.8 | No | NA | NA | No | 84 |
5 | 40 | M | Alcohol | Cirrhosis | Yes | 4.1 | No | NA | NA | Yes | 12 |
6 | 81 | F | Biliary | None | Yes | 2.2 | No | NA | NA | No | 15 |
7 | 32 | M | Alcohol | None | Yes | 3.6 | No | NA | NA | No | 21 |
8 | 78 | F | Biliary | Diabetes | Yes | 1.9 | No | NA | NA | Yes | 28 |
9 | 58 | M | Other | None | Yes | 2 | No | NA | NA | No | 51 |
10 | 60 | F | Alcohol | None | No | 2.5 | No | NA | NA | Yes | 26 |
11 | 81 | M | Biliary | None | No | 4 | No | NA | NA | Yes | 17 |
12 | 29 | M | Other | None | Yes | 7.8 | Yes | No | Hyperkalemia, volume overload | Yes | 30 |
13 | 41 | M | HTG | Diabetes | Yes | 6.6 | No | NA | NA | Yes | 18 |
14 | 77 | M | Biliary | COPD, Diabetes | No | 3.3 | No | NA | NA | Yes | 12 |
15 | 62 | F | Post-ERCP | Cholangiocarcinoma | No | 2.9 | No | NA | NA | No | 6 |
16 | 54 | M | Biliary | None | Yes | 14.6 | Yes | No | Hyperkalemia | Yes | 33 |
17 | 24 | M | HTG | COPD | Yes | 4.1 | No | NA | NA | Yes | 11 |
- Citation: Gougol A, Dugum M, Dudekula A, Greer P, Slivka A, Whitcomb DC, Yadav D, Papachristou GI. Clinical outcomes of isolated renal failure compared to other forms of organ failure in patients with severe acute pancreatitis. World J Gastroenterol 2017; 23(29): 5431-5437
- URL: https://www.wjgnet.com/1007-9327/full/v23/i29/5431.htm
- DOI: https://dx.doi.org/10.3748/wjg.v23.i29.5431