Clinical importance of colonoscopy in patients with gastric neoplasm undergoing endoscopic submucosal dissection

Table 1 Prevalence of colorectal neoplasm in the endoscopic submucosal dissection group n (%)

Colorectal neoplasm	ESD group (n = 158)
Non-lesion	78 (49.4)
Adenoma (< 1 cm)	53 (33.5)
Advanced adenoma	17 (10.8)
Large tubular adenoma (≥ 1 cm)
Tubulovillous/villous adenoma
High grade dysplasia
Early cancer (depth of mucosa/submucosa)	5 (3.2)
Advanced cancer	4 (2.5)
Neuroendocrine tumor	1 (0.6)

ESD: Endoscopic submucosal dissection.

Table 2 Comparison of characteristics between endoscopic submucosal dissection group and fecal immunochemical test group n (%)

	ESD group (n = 158)	FIT group (n = 158)	P value
Age (year, mean ± SD)	69.5 ± 8.9	69.5 ± 8.9	0.999
Gender, male/female	130 (82.3)/28 (17.7)	130 (82.3)/28 (17.7)	0.999
BMI (kg/m2)	23.0 ± 3.1	22.8 ± 3.4	0.589
Smoking	100 (63.0)	86 (54.4)	0.137
Alcohol	74 (46.8)	66 (41.8)	0.428
Diabetes mellitus	20 (12.7)	27 (17.1)	0.343
Dyslipidemia	25 (15.8)	40 (25.3)	0.051
Hypertension	73 (46.2)	88 (55.7)	0.115
History of other organs’ cancer	24 (15.2)	17 (10.8)	0.315

ESD: Endoscopic submucosal dissection; FIT: Fecal immunochemical test; BMI: Body mass index.

Table 3 Comparison of prevalence of colorectal neoplasm between endoscopic submucosal dissection group and fecal immunochemical test group n (%)

Colorectal neoplasm	ESD group (n = 158)	FIT group (n = 158)	P value
Adenoma (< 1 cm)	53 (33.5)	66 (41.8)	0.164
Advanced adenoma	17 (10.8)	24 (15.2)	0.315
Large tubular adenoma (≥ 1 cm)
Tubulovillous/villous adenoma
High grade dysplasia
Number of adenomas			0.507
1 to 3	59 (37.3)	71 (44.9)
≥ 4	11 (7.0)	19 (12.0)
Cancer or NET	10 (6.3)	10 (6.3)	0.999

ESD: Endoscopic submucosal dissection; FIT: Fecal immunochemical test; NET: Neuroendocrine tumor.

Table 4 Analysis of risk factors related to colorectal neoplasm in gastric endoscopic submucosal dissection patients n (%)

	CRN group (n = 80)	Non-CRN group (n = 78)	P value
Gender, male/female	71 (88.8)/9 (11.3)	59 (75.6)/19 (24.4)	0.031
Age (yr, mean ± SD)	70.8 ± 8.3	68.9 ± 10.4	0.215
Histopathology (adenoma/carcinoma)	69 (86.3)/11 (13.8)	70 (89.7)/8 (10.3)	0.667
Tumor size (mm, mean ± SD)	19.3 ± 12.3	19.0 ± 17.2	0.926
Tumor location
U	17 (21.3)	16 (20.5)	0.999
M	33 (41.3)	28 (35.9)	0.598
L	30 (37.5)	34 (43.6)	0.538
BMI	23.3 ± 3.3	22.7 ± 2.8	0.219
Lifestyle related disease1	16 (20.0)	13 (16.7)	0.737
Smoking	55 (68.8)	45 (57.7)	0.202
Alcohol	41 (51.3)	33 (42.3)	0.334
History of other organs’ cancer	16 (20.0)	9 (11.5)	0.215

¹The lifestyle related disease is one that is suffering from two or three of hypertension and dyslipidemia and diabetes mellitus. ESD: Endoscopic submucosal dissection; CRN: Colorectal neoplasm; BMI: body mass index.

Table 5 Analysis of risk factors related to advanced adenoma and carcinoma in gastric endoscopic submucosal dissection patients

	AAC group (n = 26)	Non-AAC group (n = 132)	P value
Gender, male/female	23 (88.5)/3 (11.5)	107 (81.1)/25 (18.9)	0.574
Age (yr, mean ± SD)	70.4 ± 8.5	69.7 ± 9.6	0.732
Histopathology (adenoma/carcinoma)	6 (23.1)/20 (76.9)	13 (9.85/119 (90.2)	0.117
Tumor size (mm, mean ± SD)	21.9 ± 12.5	18.6 ± 12.7	0.305
Tumor location
U	4 (15.4)	29 (22.0)	0.601
M	13 (50.0)	48 (36.4)	0.278
L	9 (34.6)	55 (41.7)	0.652
BMI	23.9 ± 3.8	22.8 ± 2.9	0.074
Lifestyle related disease1	9 (34.6)	20 (15.2)	0.019
Smoking	20 (76.9)	80 (60.6)	0.175
Alcohol	15 (57.7)	59 (44.7)	0.318
History of other organs’ cancer	6 (23.1)	19 (14.4)	0.415

¹The lifestyle related disease is one that is suffering from two or three of hypertension and dyslipidemia and diabetes mellitus. ESD: Endoscopic submucosal dissection; AAC: Advanced adenoma and carcinoma; BMI: Body mass index.

Table 6 Multivariate logistic regression analyses for risk ratio of overall colorectal neoplasm, and advanced adenoma and carcinoma in gastric endoscopic submucosal dissection patients

	Overall colorectal neoplasm		AAC
	OR (95%CI)	P value	OR (95%CI)	P value
Age (≥ 65 yr)	1.42 (0.68-3.00)	0.350	0.70 (0.27-1.82)	0.460
Gender (male)	2.65 (1.11-6.36)	0.029	1.85 (0.49-6.97)	0.362
BMI (≥ 25)	1.21 (0.57-2.56)	0.613	1.80 (0.71-4.58)	0.217
Lifestyle related disease1	1.24 (0.54-2.85)	0.608	3.01 (1.16-7.86)	0.024

¹The lifestyle related disease is one that is suffering from two or three of hypertension and dyslipidemia and diabetes mellitus. ESD: Endoscopic submucosal dissection; AAC: Advanced adenoma and carcinoma; BMI: Body mass index.