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May 21, 2017 (publication date) through Nov 2, 2025
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World Journal of Gastroenterology
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1007-9327
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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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Copyright ©The Author(s) 2017.
World J Gastroenterol. May 21, 2017; 23(19): 3396-3406
Published online May 21, 2017. doi: 10.3748/wjg.v23.i19.3396
Table 1 Main and opposite actions of both renin angiotensin system axes
Organ/tissueACE-Ang II- AT1 axisACE2-Ang-(1-7)-Mas axis
Blood vesselsVasoconstrictionVasodilation
HeartHypertrophic, arrithmogenicAnti-hypertrophic, anti-arrithmogenic
KidneyInflammation, fibrosisAnti-inflammatory, anti-fibrogenic
LungAlergic, fibrosisAnti-alergic, anti-fibrosis
BrainIschemiaReduction of ischemia
Adipose tissueIncrease insulin resistanceDecrease insulin resistance
ACE: Angiotensin-converting enzyme; Ang II: Angiotensin II, AT1: Angiotensin type 1 receptor; Ang-(1-7): Angiotensin-(1-7); Mas: Angiotensin-(1-7) receptor.
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