Diagnostic value of gadobenate dimeglumine-enhanced hepatocyte-phase magnetic resonance imaging in evaluating hepatic fibrosis and hepatitis

Table 1 The pathological stage of hepatic fibrosis

Stage	Description	Criteria
S0	No fibrosis	Normal connective tissue
S1	Portal fibrosis	Fibrous portal expansion
S2	Periportal fibrosis	Periportal or rare portal-portal septa
S3	Septal fibrosis	Fibrous septa with architectural distortion; no obvious cirrhosis
S4	Early cirrhosis	Cirrhosis

Table 2 The pathological grade of hepatitis

Grade	Description	Criteria
G0	No activity	No lobular inflammation and necrosis
G1	Minimal activity	Minimal, occasional spotty necrosis
G2	Mild activity	Mild, little hepatocellular damage
G3	Moderate activity	Moderate, noticeable hepatocellular change
G4	Severe activity	Severe, prominent diffuse hepatocellular damage

Table 3 Pathogeny statistics

Pathogeny	Number	Percent
Chronic hepatitis B	47	61.80%
Primary biliary cirrhosis	10	13.20%
Non-alcoholic fatty liver disease	5	6.60%
Chronic drug hepatitis	4	5.30%
Autoimmune hepatitis	2	2.60%
Alcoholic fatty liver disease	2	2.60%
Chronic hepatitis EB	2	2.60%
Hemochromatosis	1	1.30%
Hyperthyroid liver damage	1	1.30%
Hyperbilirubinemia	1	1.30%
Portal hypertension	1	1.30%

Table 4 Relative enhancement ratio in the hepatocyte phase in the five stages of hepatic fibrosis

Stage	REh (mean ± SD)	Minimum value	Maximum value
S0 (n = 16)	0.450 ± 0.195	0.129	0.698
S1 (n = 15)	0.460 ± 0.176	0.178	0.715
S2 (n = 21)	0.542 ± 0.204	0.229	1.006
S3 (n = 9)	0.364 ± 0.177	0.323	0.621
S4 (n = 15)	0.411 ± 0.184	0.184	0.836

REh: Relative enhancement ratio in the hepatocyte phase.

Table 5 Relative enhancement ratio in the hepatocyte phase in the five grades of hepatitis

Grade	REh (mean ± standard)	Minimum value	Maximum value
G1 (n = 44)	0.505 ± 0.194	0.129	1.006
G2 (n = 22)	0.402 ± 0.190	0.033	0.836
G3 (n = 8)	0.428 ± 0.147	0.182	0.621
G4 (n = 2)	0.209 ± 0.170	0.197	0.221

REh: Relative enhancement ratio in the hepatocyte phase.

Table 6 Correlation of relative enhancement ratio in the hepatocyte phase with serologic liver functional parameters

Variable	Mean	SD	Range	Coefficient factor	P value
TB	43.52	80.81	4.2-484.7	-0.3462	0.002
PT (s)	12.13	1.82	0.9-16.8	-0.130	0.263
ALB (g/L)	39.73	6.31	16.0-66.4	0.140	0.227
ALT (U/L)	124.45	166.44	16-939	-0.2901	0.011
AST (U/L)	63.46	60.47	14-351	-0.2992	0.009

¹Significantly correlated;

²More significantly correlated. The normal range of the serologic liver functional parameters: TB: 3.4-20.5 μmol/L; PT: 12-14 s; ALB: 40.0-55.0 g/L; ALT: 7-40 U/L; AST: 13-35 U/L; ALP: 50-135 U/L. TB: Total bilirubin; PT: Prothrombin time; ALT: Alanine aminotransferase; AST: Aspartate aminotransferase.