BRAF inhibitor treatment of melanoma causing colonic polyps: An alternative hypothesis

doi:10.3748/wjg.v23.i17.3022

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May 7, 2017 (publication date) through Feb 8, 2025

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. May 7, 2017; 23(17): 3022-3029
Published online May 7, 2017. doi: 10.3748/wjg.v23.i17.3022

Table 1 Selected CpG island methylation phenotype genes[33]

MINT1	BRAF	P14	RASSF2
MINT2	TIMP3	SOCS1	HAND1
MINT12	RIZ1	LOX	CACNA10
MINT17	HIC1	WRN	MGMT
MINT25	IGF2	ADAMTS1	FBN2
MINT27	IGFB3	EDIL3	THBD
MINT31	CHFR	ELM01	UCHL1
P16	NEUROG1	DUSP26	STOX2
MLH1	CRABP1	RUNX3

Table 2 Pathways enriched for BRAF mutant associated promoter methylation

BRAF mutations specific promoter	Associated genes
PI3 kinase pathway	FOXB1; FOXB2, FOXD3, CCND1, GSK3A
Insulin/IGF pathway	FOXB1; FOXB2, FOXD3; GSK3A
Hedgehog signaling pathway	SMO; GSK3A; CREBBP
Wnt signaling	NKD2; GNG4; CCND1; GSK3A; CREBBP
Transcription-regulation by bZIP transcription factor	CREBBP, MTERF; TAF7

Citation: Kelleher FC, Callaghan G, Gallagher C, O’Sullivan H. BRAF inhibitor treatment of melanoma causing colonic polyps: An alternative hypothesis. World J Gastroenterol 2017; 23(17): 3022-3029
URL: https://www.wjgnet.com/1007-9327/full/v23/i17/3022.htm
DOI: https://dx.doi.org/10.3748/wjg.v23.i17.3022