Copyright
©The Author(s) 2017.
World J Gastroenterol. May 7, 2017; 23(17): 3022-3029
Published online May 7, 2017. doi: 10.3748/wjg.v23.i17.3022
Published online May 7, 2017. doi: 10.3748/wjg.v23.i17.3022
Table 1 Selected CpG island methylation phenotype genes[33]
| MINT1 | BRAF | P14 | RASSF2 |
| MINT2 | TIMP3 | SOCS1 | HAND1 |
| MINT12 | RIZ1 | LOX | CACNA10 |
| MINT17 | HIC1 | WRN | MGMT |
| MINT25 | IGF2 | ADAMTS1 | FBN2 |
| MINT27 | IGFB3 | EDIL3 | THBD |
| MINT31 | CHFR | ELM01 | UCHL1 |
| P16 | NEUROG1 | DUSP26 | STOX2 |
| MLH1 | CRABP1 | RUNX3 |
Table 2 Pathways enriched for BRAF mutant associated promoter methylation
| BRAF mutations specific promoter | Associated genes |
| PI3 kinase pathway | FOXB1; FOXB2, FOXD3, CCND1, GSK3A |
| Insulin/IGF pathway | FOXB1; FOXB2, FOXD3; GSK3A |
| Hedgehog signaling pathway | SMO; GSK3A; CREBBP |
| Wnt signaling | NKD2; GNG4; CCND1; GSK3A; CREBBP |
| Transcription-regulation by bZIP transcription factor | CREBBP, MTERF; TAF7 |
- Citation: Kelleher FC, Callaghan G, Gallagher C, O’Sullivan H. BRAF inhibitor treatment of melanoma causing colonic polyps: An alternative hypothesis. World J Gastroenterol 2017; 23(17): 3022-3029
- URL: https://www.wjgnet.com/1007-9327/full/v23/i17/3022.htm
- DOI: https://dx.doi.org/10.3748/wjg.v23.i17.3022
