High throughput RNA sequencing utility for diagnosis and prognosis in colon diseases

Table 1 RNA markers in colorectal cancer and ulcerative colitis

Name	Level	Disease	Biomarker	Ref.
miR-143	↓	CRC	Diagnosis	[32]
miR-20a	↑	CRC	Diagnosis, prognosis	[33,37]
miR-21	↑	CRC	Diagnosis	[35]
miR-132	↓	CRC	Prognosis	[36]
DANCR	↑	CRC	Prognosis	[38]
miR-4299	↑	CRC	Chemoresistance	[39]
miR-196b	↓	CRC	Chemoresistance	[39]
miR-214	↑	Active UC and CAC	Diagnosis, prognosis	[40]

The expression levels of several microRNAs are altered in colorectal disease, specifically colorectal cancer and inflammatory bowel disease compared to non-disease states. These microRNAs have been shown to be biomarkers for several disease characteristics. CRC: Colorectal cancer; UC: Ulcerative colitis.