Barcelona clinic liver cancer nomogram and others staging/scoring systems in a French hepatocellular carcinoma cohort

Table 1 Patients’ characteristics at diagnosis (n = 1102) and first hepatocellular carcinoma recorded treatment n (%)

	All patients (n = 1102)
Age - Median (Q1-Q3), yr	68 (60-74)
Gender
Male/Female	943 (86)/159 (14)
Liver disease
Alcoholism/HCV/HBV/MS/ Other	452 (41)/297 (27)/66 (6)/99 (9)/188 (17)
Cirrhosis	895 (81)
Child - Pugh grade
A/B	653 (73)/242 (27)
Tumor Size (Q1-Q3) mm	43 (20-75)
Multifocal	654 (59)
Nodules
< 3/≥ 3	633 (57)/469 (43)
Portal vein thrombosis	452 (41)
Infiltrative HCC	469 (43)
AFP - Median [Q1-Q3], ng/mL	53 (7-1300)
ECOG (PS)
0/1-2/3-4	553 (50)/506 (46)/43 (4)
BCLC stage
A/B/C/D	187 (17)/177 (16)/658 (60)/80 (7)
Treatment allocation
Resection/RFA ± TACE	259 (23.5)
TACE	260 (23.5)
Sorafenib	342 (31)
Other palliative treatments	56 (5)
Supportive care	185 (17)

HBV: Hepatitis B virus; HCV: Hepatitis C virus; MS: Metabolic syndrome; AFP: Alpha-foetoprotein; ECOG PS: Eastern Cooperative Oncology Group Performance Status; BCLC: Barcelona Clinic Liver Cancer; RFA: Radiofrequency ablation; TACE: Trans arterial chemoembolization.

Table 2 Comparison of predictive accuracy for overall survival between the nomogram and the conventional staging and scoring systems (Barcelona clinic liver cancer, HKLC, CLIP, NIACE)

Score	Discriminatory ability linear trend test		Homogeneity likelihood ratio test		Akaike information criterion	C-index
	LT (χ²)	P value	LR (χ²)	P value
BCLC Nomogram	93.2169	< 0.0001	500.7218	< 0.0001	10679.513	0.719
NIACE	91.6906	< 0.0001	532.0369	< 0.0001	10648.198	0.718
BCLC	79.0342	< 0.0001	380.4100	< 0.0001	10805.825	0.674
HKLC	71.8861	< 0.0001	455.3169	< 0.0001	10740.918	0.698
CLIP	87.2785	< 0.0001	430.3872	< 0.0001	10749.848	0.716
Nomogram according to BCLC last version	86.1320	< 0.0001	417.4356	< 0.0001	10762.799	0.698

BCLC last version transfer single and large HCC > 50 mm from intermediate to early stages[3]. BCLC: Barcelona Clinic Liver Cancer; HCC: Hepatocellular carcinoma.