Multiple clear-cell sarcomas of small intestine with parotid gland metastasis: A case report

Table 1 Clinical, pathological, immunohistochemical and genetic features of clear-cell sarcoma of the gastrointestinal tract in previously reported cases

Ref.	Age (yr)/sex	Location	Maximum diameter of tumor(cm)	S-100	HMB-45	Melan-A	Genetic findings	Outcome
Alpers et al[5]	26/F	Jejunum	1.5	ND	ND	ND	ND	Liver mets
Ekfors et al[3]	38/M	Duodenum	3.0	Positive	Positive	ND	ND	Not given
Donner et al[6]	37/M	Ileum	6.5	Positive	Negative	ND	t(12;22)(q13;q12-13)	Liver mets at 24 and 36 mo
Fukuda et al[7]	74/M	Colon	3.0	Positive	Positive	ND	EWSR1-ATF1 by RT-PCR	Liver mets at 9 mo
Hu et al[8]	10/M	Rectum	5.0	Positive	Positive	ND	ND	NA
Pauwels et al[9]	30/M	Stomach	4.0	Positive	Negative	ND	t(12;22)(q13;q12)	LN and peritoneal mets at diagnosis
Zambrano et al[10]	15/F	Jejunum	5.0	Positive	Negative	Negative	t(12;22)(q13;q12)	DOD 16 mo
	21/F	Jejunum	4.0	Positive	Negative	Negative	ND	DOD 12 mo
	35/F	Ileum	3.5	Positive	Negative	Negative	ND	Liver mets at 12 mo
	37/F	Ileum	4.5	Positive	Negative	Negative	ND	NA
	32/M	Ileum	5.0	Positive	Negative	Negative	ND	NA
	13/M	Stomach	6.7	Positive	Negative	Negative	ND	Local recurrence at 12 mo;2nd Local recurrence at 36 mo
Achten et al[11]	57/M	Jejunum	6.5	Positive	Negative	Negative	EWSR1 rearrangement by FISH	NA
Venkataraman et al[12]	21/F	Ileum	7.0	Positive	Negative	Negative	EWSR1 rearrangement by FISH	NA
Covinsky et al[13]	47/F	Pancreas	NA	Positive	Positive	Positive	EWSR1-ATF1	NED 24 mo
							by RT-PCR and
							FISH
	85/F	Mesentery	NA	Positive	Positive	Positive	EWSR1-ATF1	DOD 1 mo
							by RT-PCR and
							FISH
Taminelli et al[14]	35/M	Ileum	1.8	Positive	Negative	Positive	EWSR1-ATF1/ by RT-PCR	DOD 15 mo
Friedrichs et al[15]	41/M	Jejunum	8.7	Positive	Negative	Negative	EWSR1 rearrangement by FISH	Liver mets at 6 mo
Huang et al[16]	40/M	Stomach	3.0	Positive	Negative	Positive	ND	NED 9 mo
Antonescu et al[17]	81/F	Colon	7.5	Positive	Negative	Negative	EWSR1-CREB1 by RT-PCR	Mets to liver and
								peritoneum at
								60 mo
	42/F	Ileum	5.7	Positive	Negative	Negative	EWSR1-CREB1 by RT-PCR	NA
	42/F	Ileum	3.5	Positive	Negative	Negative	EWSR1-CREB1 by RT-PCR	Peritoneal and
								liver mets at
								diagnosis
	51/F	Jejunum	NA	Positive	Negative	Negative	EWSR1	Peritoneal and
							rearrangement	liver mets; AWD
							by FISH
	18/F	Jejunum	NA	Positive	Negative	Negative	EWSR1-ATF1 by RT-PCR	Local recurrence
Granville et al[18]	16/M	Ileum	5.0	Positive	Negative	ND	EWSR1-ATF1 by RT-PCR; t(12;22)(q13;q12)	DOD 15 mo
Comin et al[19]	31/F	Ileum	2.8	Positive	Negative	Negative	EWSR1 rearrangement by FISH	NA
Lyle et al[20]	46/M	Jejunum	11.0	Positive	Positive	Positive	EWSR1 rearrangement by FISH; EWSR1-ATF1 by RT-PCR	NED 7 mo
	49/M	Cecum	10.5	Positive	Positive	Positive	EWSR1 rearrangement by FISH; EWSR1-ATF1 by RT-PCR	DOD 12 mo
	60/M	Jejunum	10.0	Positive	Positive	Positive	EWSR1-ATF1 by RT-PCR	DOD 28 mo
	62/M	Ileum	4.0	Positive	Positive	Positive	EWSR1 rearrangement by FISH; EWSR1-ATF1 by RT-PCR	DOD 12 mo
Abdulkader et al[21]	37/M	Jejunum	8.2	Positive	Negative	ND	EWSR1 rearrangement by FISH	Liver mets at 2 mo
Lagmay et al[22]	10/F	Stomach	7.8	Positive	Negative	Negative	EWSR1 rearrangement by FISH; EWSR1-ATF1 by RT-PCR	NED 4 mo
Joo et al[23]	60/M	Ileum	2.4	Positive	Negative	Negative	EWSR1 rearrangement by FISH	NA
	46/M	Jejunum	6.0	Positive	Negative	Negative	EWSR1 rearrangement by FISH	NA
Terazawa et al[24]	Early 20s/F	Ileum	3.0	Positive	ND	ND	EWSR1-ATF1 by RT-PCR	NED at 24 mo
Shenjere et al[25]	53/F	Ileum	5.0	Positive	Negative	Negative	EWSR1-ATF1 by RT-PCR	Regional LN mets at diagnosis/ NED at 7 mo
	26/F	Small and large bowel1	13.5/10.1	Positive	Negative	Negative	EWSR1-CREB1 by RT-PCR	NA
	66/M	Ileum	2.5	Positive	Negative	Negative	EWSR1-CREB1 by RT-PCR	Regional LN mets at diagnosis/NED
Balkaransingh et al[26]	15/M	Ileum	NA	ND	ND	ND	EWSR1 rearrangement by FISH	NA
Yang et al[27]	15/M	Ileum	4.0	Positive	ND	ND	EWSR1 rearrangement by FISH	Liver mets at 12 mo
Suárez-Vilela et al[28]	36/F	Jejunum	1.5	Positive	Negative	Negative	EWSR1 rearrangement by FISH	NA
D’Amico et al[29]	69/F	Ileum	4.0	Positive	Negative	ND	EWSR1 rearrangement by FISH	Liver mets at 2 mo
Lasithiotakis et al[30]	49/F	Jejunum	3.0	Positive	Negative	Negative	EWSR1 rearrangement by FISH	NED 20 mo
Huang et al[31]	45/F	Colon	4.0	Positive	Negative	Negative	EWSR1 rearrangement by FISH	Liver mets at 20 mo
Mallick et al[32]	45/M	Jejunum	4.4	Positive	Negative	Negative	ND	NA
Kong et al[33]	17/M	Stomach	6.0	Positive	Negative	Negative	EWSR1 rearrangement by FISH	NED 10 mo
Liu et al[34]	76/M	Jejunum	2.5	Positive	Negative	Negative	EWSR1-ATF1 by RT-PCR	NA
Thway et al[35]	36/M	Ileum	3.0	Positive	Negative	Negative	EWSR1-CREB1 by RT-PCR	DOD 7 mo
Huang [36]	36/M	Pancreas	4.0	Positive	Positive	Positive	EWSR1 rearrangement by FISH	Liver mets at 10 mo
Yegen et al[37]	25/F	Ileum	3.2	Positive	Negative	Negative	EWSR1 rearrangement by FISH	Liver mets at diagnosis and at 15 mo. Ovarian mets and peritoneal dissemination at 47 mo
Moslim et al[38]	57/M	Duodenum and Jejunum2	5.5/7.5	Positive	Negative	Positive	EWSR1 rearrangement by FISH	NED 30 mo and then DOD 4 mo later
Chen et al[39]	29/F	Jejunum	6.0	Positive	Negative	Negative	EWSR1 rearrangement by FISH	NED 17 mo
Our case	51/M	Duodenum and Jejunum3	6.5/2.5/2.5	Positive	Positive	Positive	EWSR1 rearrangement undetectable by FISH	NED up to date

¹Two simultaneous tumors in small and large bowel;

²Two simultaneous tumors in duodenum and jejunum;

³Three simultaneous tumors in duodenum and jejunum. AWD: Alive with disease; DOD: Dead of disease; FISH: Fluorescence in situ hybridisation; LN: Lymph node; Mets: Metastases; NA: Not acquired; ND: Not done; NED: No evidence of disease; RT: Reverse transcription.