Neutropenic enterocolitis

Table 1 Antibiotics and dosages for empiric treatment of neutropenic enterocolitis

Antibiotics	Dosages
Adults with NE
Monotherapy
Piperacillin-tazobactam	3.375 g IV every 6 h
Imipenem-cillastin	500 mg IV every 6 h or 1 g IV every 6-8 h
Duotherapy
Ceftazidime	1 g IV every 8-12 h
OR	OR
Cefepime	1 g IV every 8 h
Plus Metronidazole	1 g IV every 6 h
Children ( 1-12 yr of age) with NE
Monotherapy
Piperacillin-tazobactam	(> 9 mo and < 40 kg) 300 mg/kg per day IV divided every 8 h
Imipenem-cillastin	(> 3 mo) 60-100 mg/kg per day IV divided every 6 h maximum 2-4 g/d
Duotherapy
Ceftazidime	90-150 mg/kg per day IV divided every 8 h - maximum 6 g/d or
OR	50 mg/kg IV every 8 h - maximum: 2 g/dose
Cefepime
Plus Metronidazole	30 mg/kg per day IV divided every 6 h - maximum 4 g/d

Modified from Cloutier et al[44]. IV: Intravenous; NE: Neutropenic enterocolitis.