Copyright
©The Author(s) 2016.
World J Gastroenterol. Mar 7, 2016; 22(9): 2668-2677
Published online Mar 7, 2016. doi: 10.3748/wjg.v22.i9.2668
Published online Mar 7, 2016. doi: 10.3748/wjg.v22.i9.2668
Table 1 microRNAs that regulate key players of the insulin-like growth factor axis in hepatocellular carcinoma
| Downstream IGF member | Upstream microRNAs | Net effect on IGF member expression |
| IGF-I | miR-190b | Downregulated |
| miR-486-5p | Upregulated | |
| IGF-II | miR-615-5p | |
| Let-7a | Downregulated | |
| miR-96 | ||
| miR-182 | Upregulated | |
| miR-155 | ||
| IGFBPs: | miR-17-5p | Downregulated |
| IGFBP3 | ||
| IGF-1R | miR-145 | |
| miR-122 | ||
| miR-99a | ||
| miR-223 | Downregulated | |
| miR-486-5p | ||
| miR-182 | ||
| miR-1275 | ||
| miR-181a | ||
| miR-96 | ||
| miR-155 | Upregulated | |
| IGF-2R | miR-211 | Downregulated |
- Citation: El Tayebi HM, Abdelaziz AI. Epigenetic regulation of insulin-like growth factor axis in hepatocellular carcinoma. World J Gastroenterol 2016; 22(9): 2668-2677
- URL: https://www.wjgnet.com/1007-9327/full/v22/i9/2668.htm
- DOI: https://dx.doi.org/10.3748/wjg.v22.i9.2668