West C, Stanisz AM, Wong A, Kunze WA. Effects of Saccharomyces cerevisiae or boulardii yeasts on acute stress induced intestinal dysmotility. World J Gastroenterol 2016; 22(48): 10532-10544 [PMID: 28082805 DOI: 10.3748/wjg.v22.i48.10532]
Corresponding Author of This Article
Christine West, MSc Candidate, BSc, McMaster Brain-Body Institute, St. Joseph’s Healthcare, Hamilton, 50 Charlton Street East, ON L8N 4A6, Canada. westcl2@mcmaster.ca
Research Domain of This Article
Gastroenterology & Hepatology
Article-Type of This Article
Basic Study
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Gastroenterol. Dec 28, 2016; 22(48): 10532-10544 Published online Dec 28, 2016. doi: 10.3748/wjg.v22.i48.10532
Table 1 Effects of stress on gut propagating contractile clusters
Parameter
Tissue
Unstressed
Stressed
P value (t test)
Velocity (mm/s)
Jejunum
2.635 ± 0.316 (17)
1.644 ± 0.238 (17)
< 0.001
Colon
0.864 ± 0.183 (17)
1.432 ± 0.329 (17)
< 0.001
Frequency (Hz)
Jejunum
0.032 ± 0.008 (17)
0.016 ± 0.005 (17)
< 0.001
Colon
0.005 ± 0.001 (17)
0.007 ± 0.001 (17)
0.008
Peak amplitude (mm)
Jejunum
0.437 ± 0.020 (17)
0.790 ± 0.015 (17)
< 0.001
Colon
0.640 ± 0.118 (17)
0.645 ± 0.101 (17)
0.902
Table 2 Effects of Saccharomyces boulardii on propagating contractile clusters in unstressed gut
Parameter
Tissue
Unstressed
+boulardii
P value (t test)
Velocity (mm/s)
Jejunum
2.556 ± 0.299 (32)
3.229 ± 0.620 (32)
< 0.001
Colon
0.865 ± 0.148 (27)
0.633 ± 0.225 (27)
< 0.001
Frequency (Hz)
Jejunum
0.030 ± 0.018 (33)
0.035 ± 0.025 (33)
0.030
Colon
0.009 ± 0.004 (27)
0.007 ± 0.003 (27)
0.005
Peak amplitude (mm)
Jejunum
0.587 ± 0.241 (33)
0.623 ± 0.291 (33)
0.290
Colon
0.621 ± 0.190 (27)
0.543 ± 0.179 (27)
0.005
Table 3 Effects of Saccharomyces boulardii on propagating contractile clusters in stressed gut
Parameter
Tissue
Stressed
+boulardii
P value (t test)
Velocity (mm/s)
Jejunum
1.833 ± 0.688 (26)
2.627 ± 0.664 (26)
< 0.001
Colon
1.516 ± 0.263 (24)
1.036 ± 0.210 (24)
< 0.001
Frequency (Hz)
Jejunum
0.019 ± 0.013 (26)
0.032 ± 0.024 (26)
0.005
Colon
0.010 ± 0.003 (24)
0.007 ± 0.003 (24)
0.001
Peak amplitude (mm)
Jejunum
0.692 ± 0.215 (26)
0.698 ± 0.212 (26)
0.705
Colon
0.719 ± 0.249 (24)
0.657 ± 0.152 (24)
0.259
Table 4 Effects of Saccharomyces cerevisiae on propagating contractile clusters in unstressed gut
Parameter
Tissue
Unstressed
+cerevisiae
P value (t test)
Velocity (mm/s)
Jejunum
2.779 ± 0.499 (43)
3.017 ± 0.457 (43)
0.017
Colon
0.788 ± 0.212 (23)
0.858 ± 0.257 (23)
0.161
Frequency (Hz)
Jejunum
0.027 ± 0.012 (43)
0.031 ± 0.008 (43)
0.003
Colon
0.0051 ± 0.001 (23)
0.0054 ± 0.001 (23)
0.462
Peak amplitude (mm)
Jejunum
0.409 ± 0.111 (43)
0.438 ± 0.098 (43)
0.242
Colon
0.559 ± 0.176 (23)
0.508 ± 0.15 (23)
0.164
Table 5 Effects of Saccharomyces cerevisiae on propagating contractile clusters in stressed gut
Parameter
Tissue
Stressed
+cerevisiae
P value (t test)
Velocity (mm/s)
Jejunum
1.763 ± 0.397 (23)
2.017 ± 0.480 (23)
0.0031
Colon
1.647 ± 0.187 (23)
1.038 ± 0.222 (23)
< 0.001
Frequency (Hz)
Jejunum
0.016 ± 0.009 (23)
0.027 ± 0.007 (23)
< 0.001
Colon
0.008 ± 0.002 (23)
0.008 ± 0.003 (23)
0.994
Peak amplitude (mm)
Jejunum
0.761 ± 0.316 (23)
0.559 ± 0.148 (23)
0.013
Colon
0.640 ± 0.101 (23)
0.597 ± 0.103 (23)
0.190
Table 6 Effects of Saccharomyces boulardii supernatant on propagating contractile clusters in stressed gut
Parameter
Tissue
Stressed
+boulardii Snt
P value (t test)
Velocity (mm/s)
Jejunum
1.97 ± 0.39 (6)
2.585 ± 0.468 (6)
< 0.001
Colon
1.588 ± 0.194 (6)
1.11 ± 0.383 (6)
0.038
Frequency (Hz)
Jejunum
0.020 ± 0.014 (6)
0.044 ± 0.027 (6)
0.067
Colon
0.010 ± 0.001 (6)
0.007 ± 0.003 (6)
0.024
Peak amplitude (mm)
Jejunum
0.75 ± 0.285 (6)
0.737 ± 0.187 (6)
0.93
Colon
0.65 ± 0.188 (6)
0.701 ± 0.09 (6)
0.59
Table 7 Effects of Saccharomyces cerevisiae supernatant on propagating contractile clusters in stressed gut
Stressed
+cerevisiae Snt
P value (t test)
Velocity (mm/s)
Jejunum
0.713 ± 0.109 (6)
0.466 ± 0.122 (6)
0.97
Colon
1.639 ± 0.18 (6)
1.018 ± 0.245 (6)
0.002
Frequency (Hz)
Jejunum
0.018 ± 0.004 (6)
0.029 ± 0.004 (6)
0.003
Colon
0.0076 ± 0.001 (6)
0.0074 ± 0.001 (6)
0.83
Peak amplitude (mm)
Jejunum
0.713 ± 0.109 (6)
0.466 ± 0.122 (6)
0.0016
Colon
0.741 ± 0.177 (6)
0.510 ± 0.202 (6)
0.10
Citation: West C, Stanisz AM, Wong A, Kunze WA. Effects of Saccharomyces cerevisiae or boulardii yeasts on acute stress induced intestinal dysmotility. World J Gastroenterol 2016; 22(48): 10532-10544