Galamb O, Kalmár A, Barták BK, Patai &V, Leiszter K, Péterfia B, Wichmann B, Valcz G, Veres G, Tulassay Z, Molnár B. Aging related methylation influences the gene expression of key control genes in colorectal cancer and adenoma. World J Gastroenterol 2016; 22(47): 10325-10340 [PMID: 28058013 DOI: 10.3748/wjg.v22.i47.10325]
Corresponding Author of This Article
Orsolya Galamb, PhD, 2nd Department of Internal Medicine, Semmelweis University, Szentkirályi str 46, H-1088 Budapest, Hungary. orsg1@yahoo.com
Research Domain of This Article
Gastroenterology & Hepatology
Article-Type of This Article
Basic Study
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Protein kinase AMP-activated catalytic subunit alpha 2
cg06836772
0.013
0.14
227892_at
4.15 × 10-3
-0.87
238489_at
4.67 × 10-3
-0.22
SFRP1
Secreted frizzled related protein 1
cg02388150
3.33 × 10-3
0.10
202036_s_at
8.66 × 10-8
-1.47
202037_s_at
3.98 × 10-5
-1.11
202035_s_at
0.039
-0.28
SYNE1
Spectrin repeat containing nuclear envelope protein 1
cg26620959
1.32 × 10-6
0.30
209447_at
4.27 × 10-5
-0.63
AD vs N
CEMIP
Cell migration inducing hyaluronan binding protein
cg20828084
1.33 × 10-9
-0.17
1554685_a_at
1.71 × 10-11
1.12
212942_s_at
2.41 × 10-43
6.88
NT5DC3
5'-nucleotidase domain containing 3
cg06462291
7.45 × 10-5
-0.25
218786_at
6.83 × 10-9
0.76
SPATA18
Spermatogenesis associated 18
cg03103192
1.39 × 10-7
-0.15
230723_at
4.41 × 10-5
0.45
229331_at
1.20 × 10-10
1.50
DKK3
Dickkopf WNT signaling pathway inhibitor 3
cg13216057
9.64 × 10-4
0.18
202196_s_at
9.82 × 10-5
-0.65
214247_s_at
1.52 × 10-4
-0.50
PPP1R16B
Protein phosphatase 1 regulatory subunit 16B
cg24834740
2.23 × 10-9
0.36
41577_at
1.20 × 10-10
-1.44
212750_at
3.28 × 10-7
-0.81
SDC2
Syndecan 2
cg25070637
1.82 × 10-5
0.30
212158_at
1.74 × 10-10
-1.17
212157_at
2.14 × 10-8
-0.66
212154_at
9.19 × 10-5
-0.64
SFRP1
Secreted frizzled related protein 1
cg02388150
1.20 × 10-7
0.15
202036_s_at
3.62 × 10-13
-1.79
202037_s_at
4.43 × 10-11
-1.48
202035_s_at
0.016
-0.32
SYNE1
Spectrin repeat containing nuclear envelope protein 1
cg26620959
3.89 × 10-6
0.29
209447_at
5.76 × 10-15
-1.19
CRC vs AD
CEMIP
Cell migration inducing hyaluronan binding protein
cg20828084
2.00 × 10-8
0.14
212942_s_at
9.88 × 10-3
-1.17
SLC28A2
Solute carrier family 28 member 2
cg19305227
1.11 × 10-6
0.14
207249_s_at
0.027
-1.24
SPATA18
Spermatogenesis associated 18
cg03103192
6.07 × 10-12
0.16
229331_at
3.52 × 10-9
-1.73
230723_at
7.35 × 10-4
-0.41
Table 6 Whole promoter methylation status of genes with inverse age-related CpG site DNA methylation and gene expression data
Gene symbol
DNA methylation on age-related CpG site
Whole promoter DNA methylation status
cg ID
P value
Δβ
Start-Stop position
P value
Δβ
CRC vs N
AKT3
cg11314684
4.55 × 10-5
-0.16
chr1:244005801-244005900
6.56 × 10-3
-0.33
ERG
cg17274064
1.48 × 10-4
-0.11
chr21:39871501-39871600
0.044
-0.21
MGP
cg00431549
0.020
-0.12
chr12:15038501-15038600
0.030
-0.27
CCR10
cg09509673
1.91 × 10-4
0.11
chr17:40835101-40835200
0.045
0.18
chr17:40835201-40835300
0.022
0.26
PPP1R16B
cg24834740
3.56 × 10-12
0.37
chr20:37433201-37433300
3.76 × 10-3
0.35
chr20:37434701-37434800
0.048
0.40
chr20:37435301-37435400
0.042
0.37
SFRP1
cg02388150
3.33 × 10-3
0.10
chr8:41166001-41166100
0.017
0.44
chr8:41166101-41166200
1.31 × 10-4
0.56
chr8:41166201-41166300
3.40 × 10-3
0.49
chr8:41166301-41166400
0.014
0.27
chr8:41166401-41166500
1.28 × 10-3
0.53
chr8:41166501-41166600
0.027
0.44
chr8:41166601-41166700
0.034
0.39
chr8:41166901-41167000
0.042
0.41
SYNE1
cg26620959
1.32 × 10-6
0.30
chr6:152622201-152622300
0.027
0.35
chr6:152957601-152957700
0.032
0.39
chr6:152957701-152957800
0.043
0.40
chr6:152958101-152958200
2.86 × 10-4
0.65
AD vs N
CEMIP
cg20828084
1.33 × 10-9
-0.17
chr15: 81070701-81070800
0.028
-0.25
SPATA18
cg03103192
1.39 × 10-7
-0.15
chr4:52915901-52916000
0.042
-0.23
DKK3
cg13216057
9.64 × 10-4
0.18
chr11:12029701-12029800
3.11 × 10-3
0.26
chr11:12029801-12029900
1.67 × 10-3
0.33
chr11:12029901-12030000
8.08 × 10-5
0.56
chr11:12030001-12030100
0.047
0.15
chr11:12030401-12030500
7.38 × 10-3
0.28
chr11: 12030501-12030600
0.012
0.28
PPP1R16B
cg24834740
2.23 × 10-9
0.36
chr20:37434201-37434300
0.045
0.26
chr20:37434601-37434700
0.022
0.39
chr20:37434701-37434800
0.013
0.39
chr20:37434801-37434900
6.87 × 10-3
0.30
chr20:37434901-37435000
1.70 × 10-3
0.44
chr20:37435001-37435100
1.93 × 10-3
0.45
chr20:37435101-37435200
6.49 × 10-3
0.35
chr20:37435201-37435300
8.93 × 10-4
0.51
chr20:37435301-37435400
0.014
0.42
SDC2
cg25070637
1.82 × 10-5
0.30
chr8:97505901-97506000
2.30 × 10-3
0.59
chr8:97506101-97506200
1.96 × 10-4
0.65
chr8:97506201-97506300
8.43 × 10-4
0.63
chr8:97506301-97506400
0.012
0.49
chr8:97506401-97506500
0.019
0.47
chr8:97506601-97506700
3.99 × 10-3
0.51
chr8:97506701-97506800
0.021
0.45
chr8:97506801-97506900
0.014
0.52
chr8:97507101-97507200
0.015
0.44
chr8:97507201-97507300
0.010
0.52
chr8:97507301-97507400
3.47 × 10-3
0.59
SFRP1
cg02388150
1.20 × 10-7
0.15
chr8:41165901-41166000
2.30 × 10-3
0.59
chr8:41166001-41166100
1.57 × 10-3
0.59
chr8:41166101-41166200
3.54 × 10-4
0.56
chr8:41166201-41166300
1.49 × 10-4
0.60
chr8:41166301-41166400
6.54 × 10-3
0.27
chr8:41166401-41166500
1.32 × 10-5
0.55
chr8: 41166501-41166600
2.30 × 10-3
0.60
chr8:41166601-41166700
5.45 × 10-3
0.57
chr8:41166701-41166800
8.15 × 10-3
0.51
chr8:41166801-41166900
0.032
0.39
chr8:41166901-41167000
0.019
0.45
chr8:41167001-41167100
0.046
0.34
chr8:41167101-41167200
0.025
0.41
chr8:41167201-41167300
0.024
0.40
SYNE1
cg26620959
3.89 × 10-6
0.29
chr6:152702701-152702800
0.012
0.20
chr6:152702801-152702900
0.035
0.21
chr6:152957501-152957600
6.05 × 10-4
0.37
chr6:152957601-152957700
2.34 × 10-4
0.60
chr6:152957701-152957800
0.017
0.51
chr6:152957801-152957900
1.09 × 10-3
0.42
chr6:152957901-152958000
1.03 × 10-4
0.57
chr6:152958001-152958100
7.13 × 10-4
0.43
chr6:152958101-152958200
1.72 × 10-5
0.72
CRC vs AD
CEMIP
cg20828084
2.00 × 10-8
0.14
chr15:81070701-81070800
7.59 × 10-4
0.31
chr15:81070801-81070900
0.011
0.36
Citation: Galamb O, Kalmár A, Barták BK, Patai &V, Leiszter K, Péterfia B, Wichmann B, Valcz G, Veres G, Tulassay Z, Molnár B. Aging related methylation influences the gene expression of key control genes in colorectal cancer and adenoma. World J Gastroenterol 2016; 22(47): 10325-10340