Pedersen MR, Patel A, Backstedt D, Choi M, Seetharam AB. Genotype specific peripheral lipid profile changes with hepatitis C therapy. World J Gastroenterol 2016; 22(46): 10226-10231 [PMID: 28028371 DOI: 10.3748/wjg.v22.i46.10226]
Corresponding Author of This Article
Anil B Seetharam, MD, Banner Transplant and Advanced Liver Disease Center, University of Arizona College of Medicine, 1300 N. 12th Street Suite 404, Phoenix, AZ 85006, United States. anil.seetharam@bannerhealth.com
Research Domain of This Article
Gastroenterology & Hepatology
Article-Type of This Article
Prospective Study
Open-Access Policy of This Article
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World J Gastroenterol. Dec 14, 2016; 22(46): 10226-10231 Published online Dec 14, 2016. doi: 10.3748/wjg.v22.i46.10226
Table 1 Baseline demographics n (%)
All
Genotype 1
Genotype 2
Genotype 3
P value
Number of patients
321 (100)
232 (72.3)
58 (18.1)
31 (9.7)
Age (yr)
57.7 ± 10.3
58.9 ± 9.5
55.5 ± 12.1
54.6 ± 10.8
0.009
Gender (male)
221 (68.8)
160 (59.4)
41 (61.2)
20 (64.5)
0.845
Ethnicity
Caucasian
229 (71.3)
171 (73.7)
40 (70.0)
18 (58.1)
0.018
African American
19 (5.9)
18 (7.8)
1 (1.7)
0 (0.0)
Hispanic
55 (17.1)
32 (13.8)
13 (22.4)
10 (32.3)
Asian
16 (5.0)
9 (3.9)
4 (6.9)
3 (9.7)
Other
2 (0.6)
2 (0.9)
0 (0.0)
0 (0.0)
Diabetes
79 (24.6)
59 (25.4)
14 (24.2)
6 (19.4)
0.593
Hypertension
132 (41.1)
105 (45.3)
22 (37.9)
5 (16.1)
0.086
Hyperlipidemia
59 (18.4)
44 (19.0)
12 (20.7)
3 (9.7)
0.453
Cirrhotic
150 (46.7)
103 (44.4)
33 (56.9)
14 (45.2)
< 0.001
Treatment
IFN + SOF + RBV
25 (10.8)
0 (0.0)
0 (0.0)
SOF + RBV
57 (24.6)
58 (100)
31 (100)
SOF + SMV
42 (19.0)
0 (0.0)
0 (0.0)
SOF + LDV
140 (60.3)
0 (0.0)
0 (0.0)
Table 2 Changes in liver function tests
Genotype 1
Genotype 2
Genotype 3
Start Tx
End Tx
P value
Start Tx
End Tx
P value
Start Tx
End Tx
P value
Albumin (g/dL)
3.5 ± 0.6
3.8 ± 0.6
< 0.001
3.5 ± 0.5
3.7 ± 0.6
< 0.002
3.4 ± 0.5
3.7 ± 0.6
< 0.001
ALT (U/L)
70.2 ± 58.3
31.7 ± 38.7
< 0.001
68.7 ± 48.3
26.4 ± 17.8
< 0.001
101.9 ± 61.6
30.7 ± 30.3
< 0.001
Total Bilirubin (mg/dL)
1.0 ± 0.8
0.9 ± 0.8
0.008
1.0 ± 0.9
0.9 ± 0.9
0.202
1.1 ± 0.7
1.1 ± 0.8
0.904
INR
1.1 ± 0.2
1.1 ± 0.3
0.112
1.1 ± 0.1
1.0 ± 0.1
< 0.001
1.1 ± 0.2
1.1 ± 0.3
0.509
Table 3 Changes in lipid profile by genotype in patients with cirrhosis and non cirrhosis
Total population
Non-cirrhotics
Cirrhotics
Start Tx
End Tx
P value
Start Tx
End Tx
P value
Start Tx
End Tx
P value
Genotype 1
T Chol
156.9 ± 36.4
162.2 ± 41.0
0.005
169.9 ± 33.2
175.7 ± 38.2
0.046
146.4 ± 35.6
151.4 ± 40.0
0.052
HDL
51.6 ± 18.5
63.9 ± 32.8
< 0.001
54.4 ± 19.5
72.7 ± 36.4
< 0.001
49.3 ± 17.2
56.9 ± 27.6
0.002
LDL
80.2 ± 28.8
87.6 ± 62.7
0.058
87.1 ± 28.1
91.8 ± 31.6
0.091
74.6 ± 28.2
84.2 ± 79.1
0.15
TG
114.6 ± 56.0
108.7 ± 56.0
0.044
117.3 ± 55.1
111.6 ± 57.6
0.27
112.5 ± 56.6
106.4 ± 56.5
0.070
Genotype 2
T Chol
162.9 ± 35.8
163.0 ± 32.9
0.99
174.2 ± 29.8
173.7 ± 27.5
0.91
148.2 ± 37.7
148.9 ± 34.1
0.90
HDL
52.8 ± 18.6
54.8 ± 20.0
0.39
54.9 ± 17.4
55.3 ± 17.4
0.88
50.0 ± 19.7
54.0 ± 23.0
0.28
LDL
86.7 ± 34.0
87.4 ± 30.2
0.82
95.3 ± 31.8
96.4 ± 27.0
0.82
75.4 ± 33.4
75.7 ± 30.0
0.93
TG
114.3 ± 64.1
112.4 ± 65.8
0.73
120.6 ± 68.4
124.0 ± 74.2
0.72
106.1 ± 59.7
97.1 ± 48.6
0.078
Genotype 3
T Chol
141.5 ± 38.4
157.6 ± 34.4
< 0.001
161.4 ± 35.5
181.5 ± 23.5
0.001
125.1 ± 32.5
137.9 ± 29.1
0.025
HDL
45.4 ± 15.1
53.3 ± 16.6
0.038
49.3 ± 14.0
53.2 ± 14.3
0.37
42.2 ± 15.3
53.3 ± 18.2
0.065
LDL
81.4 ± 32.1
93.9 ± 34.9
< 0.001
92.5 ± 26.1
110.4 ± 21.4
0.003
72.2 ± 33.6
80.3 ± 37.9
0.045
TG
108.6 ± 47.5
98.8 ± 41.2
0.047
119.0 ± 58.6
112.6 ± 47.1
0.36
100.1 ± 33.4
87.5 ± 31.2
0.12
Table 4 Differential effect in lipid profile by genotype in patients with cirrhosis and non-cirrhosis
All patients
Non-cirrhotics
Cirrhotics
GT1
GT2
GT3
P value
GT1
GT2
GT3
P value
GT1
GT2
GT3
P value
T Chol
5.3
0.1
16.1
0.017
5.8
-0.4
12.8
0.066
5.0
0.7
20.1
0.39
HDL
12.3
2.0
7.9
0.049
18.2
0.5
11.1
0.008
7.6
4.0
4.0
0.69
LDL
-5.9
-1.1
-11.9
0.550
4.6
1.0
8.1
0.150
9.7
0.3
17.9
0.82
TG
7.4
2.1
21.2
0.130
-5.7
3.4
-12.6
0.650
-6.1
-9.0
-6.4
0.76
Citation: Pedersen MR, Patel A, Backstedt D, Choi M, Seetharam AB. Genotype specific peripheral lipid profile changes with hepatitis C therapy. World J Gastroenterol 2016; 22(46): 10226-10231