Wang MJ, Ling WW, Wang H, Meng LW, Cai H, Peng B. Non-invasive evaluation of liver stiffness after splenectomy in rabbits with CCl4-induced liver fibrosis. World J Gastroenterol 2016; 22(46): 10166-10179 [PMID: 28028365 DOI: 10.3748/wjg.v22.i46.10166]
Corresponding Author of This Article
Bing Peng, MD, PhD, Department of Pancreatic Surgery, West China Hospital, Sichuan University, No. 37, Guoxue Alley, Chengdu 610041, Sichuan Province, China. wmjjmw01pb@126.com
Research Domain of This Article
Gastroenterology & Hepatology
Article-Type of This Article
Basic Study
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Table 5 Cutoff and performance values of elastography point quantification for diagnosis of liver fibrosis stages
Parameter
F0-F1 vs F2-F4
F0-F2 vs F3-F4
F0-F3 vs F4
AUROC
0.931 (0.849-0.977)
0.969 (0.901-0.995)
0.925 (0.841-0.973)
Optimal cutoff value
11.27
14.89
18.21
Sensitivity (%)
82.5 (70.1-91.3)
87.8 (73.8-95.9)
88.0 (68.8-97.5)
Specificity (%)
94.7 (74.0-99.9)
94.3 (80.8-99.3)
84.3 (71.4-93.0)
PPV (%)
97.9 (88.9-99.9)
94.7 (82.3-99.4)
73.3 (54.1-87.7)
NPV (%)
64.3 (44.1-81.4)
86.8 (71.9-95.6)
93.5 (82.1-98.6)
Table 6 Longitudinal changes in liver stiffness measurement (kPa) via elastography point quantification between splenectomy and sham groups
POW 0
POW 2
POW 4
POW 6
POW 8
POW 10
F1
Group S (n = 5)
8.46 (6.63-8.50)
8.74 (6.97-8.91)
11.34 (9.13-12.89)
14.32 (11.45-15.45)
18.89 (16.43-19.23)
19.24 (17.78-21.09)
Group L (n = 4)
8.59 (7.12-10.13)
12.79 (11.01-14.62)
14.35 (12.24-16.70)
16.30 (13.25-20.07)
21.01 (16.11-25.45)
23.34 (20.66-26.15)
F2
Group S (n = 4)
10.81 (8.34-13.48)
14.45 (12.53-15.70)
18.28 (16.72-18.56)
20.73 (18.09-22.26)
25.50 (23.10-25.89)
30.79 (27.29-33.31)
Group L (n = 4)
10.50 (9.31-11.96)
15.39 (13.55-16.92)
17.90 (16.01-19.27)
20.25 (18.92-21.51)
23.89 (23.15-25.24)
30.60 (28.54-32.29)
F3
Group S (n = 4)
19.19 (17.77-21.25)
22.90 (20.70-25.17)
26.99 (25.13-28.88)
29.98 (26.14-33.23)
32.38 (29.06-35.89)
35.79 (33.79-37.31)
Group L (n = 4)
22.08 (18.24-25.35)
25.17 (21.79-27.59)
27.21 (24.38-30.23)
29.72 (28.27-30.70)
31.89 (29.91-33.98)
32.22 (30.70-34.71)
F4
Group S (n = 3)
27.56 (23.40-28.34)
31.23 (26.84-32.22)
30.12 (27.89-32.12)
36.12 (32.39-36.34)
35.10 (34.12-36.27)
36.12 (34.06-37.28)
Group L (n = 3)
23.98 (20.21-28.66)
29.12 (23.68-31.19)
32.00 (28.17-33.00)
29.00 (28.56-32.56)
33.43 (33.32-35.32)
35.30 (35.25-37.21)
Table 7 Longitudinal changes in liver function between splenectomy and sham groups
POW 0
POW 2
POW 4
POW 6
POW 8
POW 10
AST (IU/L)
F1
Group S (n = 5)
138.0 ± 87.3
236.7 ± 110.6
484.3 ± 244.2
307.3 ± 138.9
454.0 ± 291.3
574.3 ± 350.6
Group L (n = 4)
447.0 ± 292.7
245.5 ± 98.3
589.5 ± 140.7
455.0 ± 309.7
517.5 ± 55.9
470.0 ± 155.6
F2
Group S (n = 4)
353.6 ± 208.4
473.4 ± 212.1
426.0 ± 186.4
448.6 ± 286.4
658.2 ± 221.9
575.6 ± 104.4
Group L (n = 4)
392.0 ± 290.5
493.5 ± 269.0
407.5 ± 100.4
506.3 ± 156.8
494.5 ± 88.8
550.0 ± 125.6
F3
Group S (n = 4)
578.3 ± 219.5
681.3 ± 208.9
534.0 ± 292.2
622.7 ± 286.2
584.7 ± 144.5
713.3 ± 122.8
Group L (n = 4)
598.8 ± 219.5
569.8 ± 208.9
651.5 ± 292.2
513.0 ± 286.2
435.5 ± 144.5
831.8 ± 122.8
F4
Group S (n = 3)
562.2 ± 356.6
604.2 ± 314.3
578.4 ± 247.7
623.8 ± 101.1
672.6 ± 122.6
525.6 ± 153.2
Group L (n = 3)
412.6 ± 190.9
508.7 ± 253.8
604.0 ± 121.8
616.7 ± 203.1
571.0 ± 145.7
480.3 ± 91.4
ALT (IU/L)
F1
Group S (n = 5)
88.7 ± 39.2
270.3 ± 144.9
460.7 ± 227.5
379.0 ± 179.2
526.7 ± 185.8
440.7 ± 220.4
Group L (n = 4)
195.0 ± 39.6
322.0 ± 76.4
430.5 ± 2.1
445.0 ± 108.9
560.5 ± 87.0
372.0 ± 198.0
F2
Group S (n = 4)
224.6 ± 187.8
240.8 ± 96.7
355.8 ± 165.8
342.6 ± 165.1
436.8 ± 74.9
458.0 ± 92.4
Group L (n = 4)
291.8 ± 65.9
364.3 ± 86.5
310.3 ± 35.8
414.5 ± 136.8
473.3 ± 140.5
498.3 ± 174.0
F3
Group S (n = 4)
315.7 ± 232.7
434.0 ± 171.8
528.3 ± 137.7
588.0 ± 61.6
461.3 ± 208.2
497.3 ± 73.6
Group L (n = 4)
477.8 ± 151.7
484.0 ± 34.4
459.3 ± 132.5
601.0 ± 274.9
488.8 ± 210.2
507.0 ± 133.2
F4
Group S (n = 3)
416.8 ± 286.2
490.6 ± 43.3
626.2 ± 93.0
478.0 ± 83.3
550.6 ± 252.5
519.2 ± 44.9
Group L (n = 3)
529.0 ± 167.0
475.8 ± 106.7
600.4 ± 116.3
512.6 ± 207.8
576.8 ± 233.1
695.4 ± 150.6
Albumin (g/L)
F1
Group S (n = 5)
41.6 ± 2.4
40.5 ± 1.8
39.4 ± 2.3
40.5 ± 3.4
40.0 ± 2.0
39.8 ± 1.7
Group L (n = 4)
41.3 ± 4.9
40.2 ± 3.0
40.3 ± 1.8
39.3 ± 0.6
39.3 ± 2.0
40.7 ± 1.3
F2
Group S (n = 4)
39.0 ± 1.9
38.3 ± 1.9
38.3 ± 1.5
38.9 ± 2.0
38.9 ± 1.6
38.9 ± 0.8
Group L (n = 4)
39.6 ± 1.6
39.6 ± 1.7
38.0 ± 1.5
39.5 ± 0.8
39.0 ± 1.4
38.9 ± 1.9
F3
Group S (n = 4)
30.7 ± 4.3
30.3 ± 3.9
29.8 ± 3.3
31.0 ± 3.0
30.2 ± 3.8
30.5 ± 4.1
Group L (n = 4)
31.1 ± 5.7
30.8 ± 5.1
31.8 ± 4.6
30.6 ± 5.2
30.9 ± 4.9
30.3 ± 4.2
F4
Group S (n = 3)
35.8 ± 5.6
36.0 ± 4.7
34.5 ± 4.1
34.2 ± 4.8
35.1 ± 5.1
35.5 ± 3.6
Group L (n = 3)
35.3 ± 6.6
34.9 ± 5.8
35.4 ± 6.1
34.8 ± 3.4
34.8 ± 4.9
35.0 ± 5.6
TB (μmol/L)
F1
Group S (n = 5)
1.08 ± 0.10
1.30 ± 0.16
1.60 ± 0.16
1.58 ± 0.18
1.71 ± 0.23
1.70 ± 0.22
Group L (n = 4)
1.34 ± 0.16
1.38 ± 0.08
1.39 ± 0.08
1.65 ± 0.20
1.51 ± 0.19
1.58 ± 0.25
F2
Group S (n = 4)
2.01 ± 0.72
2.35 ± 0.58
2.45 ± 0.61
2.65 ± 0.47
2.76 ± 0.51
2.81 ± 0.54
Group L (n = 4)
2.08 ± 0.23
2.45 ± 0.51
2.62 ± 0.45
2.67 ± 0.23
2.99 ± 0.15
2.68 ± 0.40
F3
Group S (n = 4)
2.36 ± 0.64
2.52 ± 0.64
2.62 ± 0.51
2.66 ± 0.29
2.97 ± 0.19
3.09 ± 0.10
Group L (n = 4)
2.59 ± 0.76
2.87 ± 0.42
2.88 ± 0.48
2.94 ± 0.33
3.13 ± 0.20
3.09 ± 0.12
F4
Group S (n = 3)
2.30 ± 0.56
2.58 ± 0.54
2.73 ± 0.22
2.88 ± 0.18
3.05 ± 0.26
3.03 ± 0.38
Group L (n = 3)
2.35 ± 0.84
2.49 ± 0.52
2.82 ± 0.67
2.96 ± 0.13
3.11 ± 0.48
3.08 ± 0.51
Citation: Wang MJ, Ling WW, Wang H, Meng LW, Cai H, Peng B. Non-invasive evaluation of liver stiffness after splenectomy in rabbits with CCl4-induced liver fibrosis. World J Gastroenterol 2016; 22(46): 10166-10179