Clinical features of upper gastrointestinal serrated lesions: An endoscopy database analysis of 98746 patients

Table 1 General information on patients with serrated lesions in upper gastrointestinal tract

	n (%)
Total	21
Mean age (yr), mean ± SD	55.3 ± 17.2
Gender, male	11 (52.4)
Body mass index (kg/m2), mean ± SD	24.9 ± 5.8
18.5-23.9	13 (61.9)
≥ 24.0	8 (38.1)
History of smoking	7 (33.3)
Alcohol consumption	10 (47.6)
Family history of gastric cancer	1 (4.8)
Indications for endoscopy
Upper abdominal pain	5 (23.8)
Nausea, vomit and reflux	4 (19.0)
Anemia and edema	4 (19.0)
Positive fecal occult blood test	3 (14.3)
A history of gastric polyps	3 (14.3)
Dyspepsia	2 (9.5)

Table 2 Clinical features of serrated lesions in upper gastrointestinal tract

	n (%)
Size (mm), mean ± SD	11.7 ± 10.3
≤ 5	8 (38.1)
5-10	4 (19.0)
10-20	6 (28.6)
20-30	1 (4.8)
≥ 30	2 (9.5)
Distribution
Esophagus	1 (4.8)
Cardia	3 (14.3)
Corpus	9 (42.9)
Antrum	5 (23.8)
Duodenum	3 (14.3)
Morphology
Serrated hyperplasia	6 (28.6)
Hyperplastic polyps	8 (38.1)
Adenoma	6 (28.6)
Adenocarcinoma	1 (4.8)
Situation of serrated lesions in mucosal lesions
Inflammation or ulcer	3 (14.3)
Serrated polyps	14 (66.7)
Ménétrier gastropathy	3 (14.3)
Duodenal cancer	1 (4.8)
Colonoscopy findings	18
No-polyp	4 (22.2)
Hyperplastic polyps	7 (38.9)
Non-advanced adenomas	3 (16.7)
Advanced adenomas	4 (22.2)
Tubular adenoma with high grade dysplasia	1 (5.6)
Tubulovillous adenoma	2 (11.1)
Adenoma > 10 mm	1 (5.6)

Table 3 Colonoscopy findings in the patients with serrated lesions in upper gastrointestinal tract

Serrated lesions in upper gastrointestinal tract mucosal lesions (n)	Colonoscopy findings (n)
Inflammation or ulcer (3)	HPs (1)
HPs (8)	AA (2), NAA (1), HPs (2)
Serrated adenoma (6)	AA (2), NAA (2), HPs (2)
Ménétrier gastropathy (3)	HPs (2)
Duodenal cancer (1)	Absent

HPs: Hyperplastic polyps; AA: Advanced adenoma; NAA: Non-advanced adenoma.

Table 4 Prevalence of colorectal adenoma in patients with serrated lesions in upper gastrointestinal tract and the control group n (%)

	Patients with serrated lesions in UPGI(n = 18)	Average group(n = 72)	OR (95%CI)	P value
Colorectal adenoma	7 (38.9)	8 (11.1)	5.091 (1.534-16.890)	0.010
Non-advanced adenoma	3 (16.7)	5 (6.9)	2.680 (0.576-12.463)	0.195
Advanced adenoma	4 (22.2)	3 (4.2)	6.571 (1.322-32.660)	0.028