Host restriction factors for hepatitis C virus

Table 1 Summary of host restriction factors for hepatitis C virus

Host restriction factor	HCV life cycle step	IFN induceble or not	Ref.
IFITM1	Entry	Y	[19]
IFITM1	Replication	Y	[38]
Ficolin-2	Entry	N	[20]
EMR	Entry	N	[21]
Moesin	Replication	N	[21]
TRIM14	Replication	Y	[16]
NOS2	Replication	Y	[16]
IFITM3	Replication	Y	[16]
ISG56	Replication	Y	[38]
Viperin	Replication	Y	[17,58,59]
CIDEB	Replication	N	[33,63]
Xrn1	Replication	N	[66-70]
Xrn2	Replication	N	[67,68]
APOBEC3G	Replication	N	[76,77]
Sac1	Replication	N	[83,84]
ACBD3	Replication	N	[91]
SOCS3	Replication	N	[97]
MSR1	Replication	N	[103]
BST-2	Particle production and release	Y	[125-127]
PKD	Secretion and release	N	[132]
YB-1	Particle production	N	[137,138]

HCV: Hepatitis C virus; IFN: Interferon; IFITM1: Interferon-induced transmembrane protein 1; EMR: Ezrin-moesin-radixin; TRIM14: Tripartite motif containing 14; NOS2: Nitric oxide synthase 2; IFITM3: Interferon-induced transmembrane protein 3; CIDEB: Cell-death-inducing DFFA-like effector b; APOBEC3G: Apolipoprotein B messenger RNA-editing enzyme catalytic polypeptide-like 3G; ACBD3: Acyl-coenzyme A binding domain containing protein 3; SOCS3: Suppressor of cytokine signaling 3; BST-2: Bone marrow stromal cell antigen 2; PKD: Protein kinase D; YB-1: Y-box-binding protein 1.