Diagnostic imaging advances in murine models of colitis

Table 1 Tracer-antibodies used in fluorescence endoscopy and confocal laser endomicroscopy

Publication	Tracer	Application	Method	Mouse model
Charanya et al[98], 2014	Cypate- cyclic peptide sequence, D-Cys-Gly-Arg-Asp-Ser-Pro-Cys-Lys [c(DCGRDSPC)K]	Topical	FE	AOM-CRC, mice
Gounaris et al[157], 2013	ProSense 680	Intravenous	FE and Fluorescence	IL-10-/- mice, mice
			Reflectance Imaging
Joshi et al[99], 2012	Cy5.5-AKPGYLS peptide multimer	Topical	FE	CPC; Apc mice
Miller et al[100], 2011	FITC-Ahx-QPIHPNNM peptide	Topical	FE	CPC; Apc mice
Urano et al[158], 2011	gGlu-HMRG	Topical	Laparoscopy + FE	diss. Ovarial-Ca, mice
Foersch et al[86], 2010	VEGF-Ab	Topical	Colonoscopy + CLE	APCmin mice, Stomach cancer
Goetz et al[87], 2010	EGFR-Ab	Intravenous	CLE	Balb/c nu/nu mice, CRC-cells implanted
Funovics et al[159], 2006	Cy5.5 nano particle u.	Intravenous	Colonoscopy + FE	APCmin mice, CT26 (CRC) in nu/nu
	AF750-Beacon

FE: Fluorescence endoscopy; AOM: Azoxymethane; CRC: Colorectal cancer; IL-10: Interleukin 10; Cy5.5: Cyanine 5.5; CPC: Cdx2-Cre transgene; Apc: Adenomatous polyposis coli; FITC: Fluoresceinisothiocyanat; Ahx: Aminohexanoic acid, HMRG: Hydroxymethylrhodamine green; VEGF: Vascular endothelial growth factor; CLE: Confocal laser endomicroscopy; EGFR: Epidermal growth factor receptor; Balb: Albino laboratory-bred mouse strain; AF750: Alexa fluor 750; CT26: Cancer cell line.