Low expression of ARID1A correlates with poor prognosis in intrahepatic cholangiocarcinoma

Table 1 Clinicopathological features of IHCC patients and the correlation between ARID1A protein expression and clinicopathological parameters

Characteristics	ARID1A		P value
	Low expression	High expression
	n = 19	n = 38
Age (yr)			0.703
< 50	7	16
≥ 50	12	22
Sex			0.546
Female	7	11
Male	12	27
Child-classification			0.500
A	15	34
B	4	4
Differentiation			0.546
Well	10	12
Moderately	4	13
Poorly	5	13
Tumor size (cm)			0.306
> 3	15	25
≤ 3	4	13
Tumor nodule			< 0.001
Solitary	7	32
Multiple	12	6
Vein invasion			0.004
Positive	13	11
Negative	6	27
Recurrence status			0.004
Yes	16	17
No	3	21

IHCC: Intrahepatic cholangiocarcinoma.

Table 2 Multivariate analysis of overall survival and disease-free survival on ARID1A protein expression in patients with intrahepatic cholangiocarcinoma (Cox proportional hazards model)

Prognostic factors	Overall survival		Disease-free survival
	Hazard ration(95%CI)	P value	Hazard ration(95%CI)	P value
Tumor nodule
Solitary vs multiple	0.292 (0.093-0.914)	0.034	1.092 (0.328-3.639)	0.886
Vein invasion
Positive vs negative	0.181 (0.079-0.413)	< 0.001	1.207 (0.509-2.859)	0.669
ARID1A expression
Low vs high	7.240 (2.281-22.980)	< 0.001	3.967 (1.299-12.118)	0.016