Dominating expression of negative regulatory factors downmodulates major histocompatibility complex Class-II expression on dendritic cells in chronic hepatitis C infection

Table 1 List of selected genes for custom PCR array

CD209	CSF1R	ADAMDEC1	PDCD1	HLA-DPB1	HLA-DQA1	HLA-DQB1	HMOX1	ITGB2	CD40	CD80	CD86
CD83	LY75	LAMP3	ARHGDIB	CCL5	CCL8	TLR2	CCL22	CCR7	CXCR3	CXCR4	CXCL6
CXCL9	CXCL10	CXCL11	CXCL12	CXCL16	ITGAX	ICAM1	VCL	TLR8	NFKB1	NFKB2	CD1A
CD1B	CD1C	CD52	S100A4	RELB	IDO1	CD274	IFNAR1	IFNAR2	IRF1	IRF3	CD44
IRF7	IRF9	STAT1	STAT2	ADAR	EIF2AK2	IFI6	IFI27	IFI35	OAS1	OAS2	OAS3
PRKRA	SOD2	MX1	MX2	ISG15	ISG20	IFIT1	FAS	LITAF	IFIT3	IFITM1	ITIH2
GBP1	GBP2	PIAS1	PIAS2	SOCS1	SOCS2	SOCS3	SOCS4	SOCS5	IL28B	TRIM22	RARRES3
TAP1	TAP2	RELA	TLR3	TLR4	TLR7	TLR9	GAPDH	ACTB	HGDC	RTC	PPC

Table 2 Clinical characteristics of study subjects

Parameter	Responder	Non-responder
Mean viral load (IU/mL)	6.09 ± 0.29	5.97 ± 0.81
Mean age (yr)	42.0 ± 2.8	47 ± 2.9
Male/Female	6/4	8/2
Mean TB/CB (mg/dL)	0.75 ± 0.10	1.25 ± 0.20
Mean AST (U/L)	94.77 ± 23.40	102.3 ± 12.7
Mean ALT (U/L)	155.4 ± 45.2	111.2 ± 18.3
Mean AP (U/L)	94.50 ± 8.20	160.00 ± 24.44
Mean A/G (mg/dL)	1.25 ± 0.10	1.74 ± 0.10
(Fibrosis) Median LSM (kPa)	6.10	23.50 (P = 0. 01)

TB/CB: Total bilirubin/conjugated bilirubin; AST: Aspartate transaminase; ALT: Alanine transaminase; AP: Alkaline phosphatases; A/G: Albumin/globulin; LSM: Liver stiffness measurement.