Longitudinal molecular characterization of endoscopic specimens from colorectal lesions

Table 1 Patient characteristics

Adenomas	94
Gender
Women	39
Aged	34-98 (median 67.7)
Men	55
Aged	40-89 (median 68.0)
Localization
Proximal colon	37
Distal colon	42
Rectum	15
Histology
Tubular	47
Tubulovilous	39
Vilous	4
Serrated	4
Dysplasia
Low-grade	78
High-grade	16
Carcinomas	127
Gender
Women	44
Aged	34-98 (median 70.2)
Men	83
Aged	42-90 (median 68.5)
Localization
Proximal colon	50
Distal colon	38
Rectum	39
Stage
Early (I and II)	66
Advanced (III and IV)	61

Table 2 Overview of the molecular testing results n (%)

Marker	Localization	Advanced adenoma1	Early carcinoma2	Late carcinoma3
MSI	Proximal	0 (0)	5 (20)	7 (24.14)
	Distal	0 (0)	0 (0)	0 (0)
	Rectum	0 (0)	0 (0)	0 (0)
CIMP	Proximal	13 (30.95)	15 (65.22)	16 (59.25)
	Distal	7 (16.28)	10 (45.45)	6 (35.29)
	Rectum	2 (13.33)	11 (50.22)	8 (47.06)
BRAF	Proximal	7 (10.94)	4 (17.39)	7 (24.14)
	Distal	1 (1.49)	0 (0.00)	0 (0.00)
	Rectum	4 (17.39)	1 (4.20)	2 (11.11)
KRAS	Proximal	25 (35.71)	11 (44.00)	15 (51.72)
	Distal	28 (43.08)	11 (44.00)	4 (23.53)
	Rectum	12 (50.00)	10 (41.67)	7 (38.88)
APC	Proximal	24 (35.82)	5 (20.83)	5 (17.24)
	Distal	22 (34.38)	8 (34.78)	6 (37.5)
	Rectum	9 (37.50)	7 (29.17)	8 (44.44)
TP53	Proximal	5 (7.46)	8 (33.33)	8 (27.59)
	Distal	2 (3.13)	8 (34.78)	8 (50.00)
	Rectum	1 (4.17)	11 (45.83)	10 (55.55)

¹> 1 cm;

²Stage I or II;

³Stage III or IV.