Changes in patients’ symptoms and gastric emptying after Helicobacter pylori treatment

Table 1 Comparison of baseline characteristics between the functional dyspepsia and control groups

Group	Age	Sex (male/female)	BMI (kg/m2)	Duration of disease (yr)
FD group (n = 70)	44.82 ± 13.41	27/43	21.38 ± 3.87	2.01 ± 1.32
Control group (n = 72)	40.70 ± 6.39	22/48	21.20 ± 2.95	1.89 ± 1.73
t-test value	t = 2.347	χ2 = 0.785	t = 0.312	t = 0.464
P value	0.020	0.376	0.755	0.644
H. pylori therapeutic group	42.73 ± 11.97	10/18	20.98 ± 3.27	2.10 ± 1.12
Conventional therapeutic group	43.79 ± 14.28	9/12	22.08 ± 2.96	1.97 ± 1.28
H. pylori-negative group	45.82 ± 12.83	8/13	21.16 ± 3.64	1.95 ± 1.31
t-test value	F = 2.191	F = 2.315	F = 1.923	F = 1.872
P value	0.266	0.221	0.397	0.426

BMI: Body mass index; FD: Functional dyspepsia; H. pylori: Helicobacter pylori.

Table 2 Incidence of dyspeptic symptoms in functional dyspepsia and control groups n (%)

Groups	Abdominal pain	Epigastric burning sensation	Abdominal distension	Nausea	Belching	Vomiting	Early satiety
FD group (n = 70)	35 (50.0)	26 (37.1)	55 (78.6)	32 (45.7)	37 (52.9)	11 (15.7)	40 (57.1)
Control (n = 72)	15 (20.8)	9 (12.5)	32 (44.4)	16 (22.2)	5 (15.3)	7 (9.7)	14 (19.4)
χ2 value	18.642	16.224	24.699	12.314	31.456	1.624	30.087
P value	0.000	0.000	0.000	0.000	0.000	0.203	0.000

FD: Functional dyspepsia.

Table 3 Comparison of gastric half-emptying time between functional dyspepsia and control groups

Groups	Gastric half-emptying time at the proximal end (min)	Gastric half-emptying time at the distal end (min)	Gastric half-emptying time at the whole gastric region (min)
FD group (n = 70)	93.7 ± 26.2	102.2 ± 26.4	102.1 ± 28.6
Control group (n = 72)	72.0 ± 14.3	87.5 ± 18.2	78.3 ± 14.1
t value	6.149	3.782	6.316
P value	0.000	0.000	0.000

FD: Functional dyspepsia.

Table 4 Logistic regression analysis of symptoms of dyspepsia and gastric half-emptying time

Influential factors	Prolonged gastric half-emptying time	β	SE	Wald value	OR	95%CI	P value
Abdominal pain	Proximal	0.255	0.322	5.743	1.291	0.687-2.426	0.791
	Distal	0.123	0.429	6.841	1.131	0.488-2.622	0.387
	Whole	0.780	0.117	15.935	2.182	1.735-2.744	0.008
Epigastric burning sensation	Proximal	0.653	0.412	6.472	1.921	0.857-4.308	0.391
	Distal	-0.272	0.366	5.937	0.762	0.372-1.561	0.752
	Whole	-0.183	0.621	6.935	0.833	0.247-2.814	0.326
Abdominal distension	Proximal	-0.451	0.429	7.299	0.637	0.275-1.477	0.261
	Distal	0.600	0.128	15.643	1.823	1.419-2.343	0.016
	Whole	0.273	0.118	14.984	1.314	1.043-1.656	0.021
Nausea	Proximal	0.545	0.529	8.327	1.725	0.612-4.865	0.134
	Distal	0.205	0.326	7.565	1.227	0.648-2.325	0.142
	Whole	0.699	0.762	7.418	2.011	0.452-8.954	0.221
Belching	Proximal	0.023	0.376	7.488	1.023	0.490-2.138	0.172
	Distal	0.745	0.223	12.473	2.106	1.360-3.260	0.031
	Whole	-0.583	0.515	9.304	0.558	0.203-1.531	0.086
Early satiety	Proximal	-0.467	0.718	8.471	0.627	0.153-2.561	0.096
	Distal	0.461	0.202	13.845	1.585	1.067-2.355	0.026
	Whole	-0.028	0.486	8.737	0.972	0.375-2.520	0.093

Table 5 Comparison of total symptom scores of patients before and after treatment

Groups	Before treatment	After treatment	Q value	P value
H. pylori treatment group (n = 21)	10.14 ± 4.02	5.15 ± 2.27	4.953	0.000
Conventional treatment group (n = 21)	11.01 ± 3.92	7.02 ± 3.04	3.686	0.001
H. pylori-negative group (n = 28)	11.61 ± 4.81	4.93 ± 3.22	6.107	0.000

H. pylori: Helicobacter pylori.

Table 6 Comparison of gastric half-emptying time (min) of patients after treatment

Groups	Gastric half-emptying time at the proximal end	Gastric half-emptying time at the distal end	Gastric half-emptying time at whole gastric region
(1) H. pylori treatment group (n = 21)	74.0 ± 12.4	87.7 ± 13.4	80.3 ± 14.4
(2) Conventional treatment group (n = 21)	83.1 ± 15.8	97.5 ± 15.1	91.9 ± 17.2
(3) H. pylori-negative group (n = 28)	73.6 ± 11.7	88.3 ± 15.4	79.8 ± 15.9
F value	3.211	3.143	3.188
P value	0.004	0.019	0.007
(1):(2) Q value	2.076	2.225	2.37
P value	0.044	0.032	0.023
(1):(3) Q value	0.115	0.143	0.107
P value	0.909	0.887	0.915
(3):(2) Q value	2.317	2.087	2.516
P value	0.025	0.042	0.015

H. pylori: Helicobacter pylori.