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©The Author(s) 2016.
World J Gastroenterol. May 14, 2016; 22(18): 4585-4593
Published online May 14, 2016. doi: 10.3748/wjg.v22.i18.4585
Published online May 14, 2016. doi: 10.3748/wjg.v22.i18.4585
Table 1 Comparison of baseline characteristics between the functional dyspepsia and control groups
Group | Age | Sex (male/female) | BMI (kg/m2) | Duration of disease (yr) |
FD group (n = 70) | 44.82 ± 13.41 | 27/43 | 21.38 ± 3.87 | 2.01 ± 1.32 |
Control group (n = 72) | 40.70 ± 6.39 | 22/48 | 21.20 ± 2.95 | 1.89 ± 1.73 |
t-test value | t = 2.347 | χ2 = 0.785 | t = 0.312 | t = 0.464 |
P value | 0.020 | 0.376 | 0.755 | 0.644 |
H. pylori therapeutic group | 42.73 ± 11.97 | 10/18 | 20.98 ± 3.27 | 2.10 ± 1.12 |
Conventional therapeutic group | 43.79 ± 14.28 | 9/12 | 22.08 ± 2.96 | 1.97 ± 1.28 |
H. pylori-negative group | 45.82 ± 12.83 | 8/13 | 21.16 ± 3.64 | 1.95 ± 1.31 |
t-test value | F = 2.191 | F = 2.315 | F = 1.923 | F = 1.872 |
P value | 0.266 | 0.221 | 0.397 | 0.426 |
Table 2 Incidence of dyspeptic symptoms in functional dyspepsia and control groups n (%)
Groups | Abdominal pain | Epigastric burning sensation | Abdominal distension | Nausea | Belching | Vomiting | Early satiety |
FD group (n = 70) | 35 (50.0) | 26 (37.1) | 55 (78.6) | 32 (45.7) | 37 (52.9) | 11 (15.7) | 40 (57.1) |
Control (n = 72) | 15 (20.8) | 9 (12.5) | 32 (44.4) | 16 (22.2) | 5 (15.3) | 7 (9.7) | 14 (19.4) |
χ2 value | 18.642 | 16.224 | 24.699 | 12.314 | 31.456 | 1.624 | 30.087 |
P value | 0.000 | 0.000 | 0.000 | 0.000 | 0.000 | 0.203 | 0.000 |
Table 3 Comparison of gastric half-emptying time between functional dyspepsia and control groups
Groups | Gastric half-emptying time at the proximal end (min) | Gastric half-emptying time at the distal end (min) | Gastric half-emptying time at the whole gastric region (min) |
FD group (n = 70) | 93.7 ± 26.2 | 102.2 ± 26.4 | 102.1 ± 28.6 |
Control group (n = 72) | 72.0 ± 14.3 | 87.5 ± 18.2 | 78.3 ± 14.1 |
t value | 6.149 | 3.782 | 6.316 |
P value | 0.000 | 0.000 | 0.000 |
Table 4 Logistic regression analysis of symptoms of dyspepsia and gastric half-emptying time
Influential factors | Prolonged gastric half-emptying time | β | SE | Wald value | OR | 95%CI | P value |
Abdominal pain | Proximal | 0.255 | 0.322 | 5.743 | 1.291 | 0.687-2.426 | 0.791 |
Distal | 0.123 | 0.429 | 6.841 | 1.131 | 0.488-2.622 | 0.387 | |
Whole | 0.780 | 0.117 | 15.935 | 2.182 | 1.735-2.744 | 0.008 | |
Epigastric burning sensation | Proximal | 0.653 | 0.412 | 6.472 | 1.921 | 0.857-4.308 | 0.391 |
Distal | -0.272 | 0.366 | 5.937 | 0.762 | 0.372-1.561 | 0.752 | |
Whole | -0.183 | 0.621 | 6.935 | 0.833 | 0.247-2.814 | 0.326 | |
Abdominal distension | Proximal | -0.451 | 0.429 | 7.299 | 0.637 | 0.275-1.477 | 0.261 |
Distal | 0.600 | 0.128 | 15.643 | 1.823 | 1.419-2.343 | 0.016 | |
Whole | 0.273 | 0.118 | 14.984 | 1.314 | 1.043-1.656 | 0.021 | |
Nausea | Proximal | 0.545 | 0.529 | 8.327 | 1.725 | 0.612-4.865 | 0.134 |
Distal | 0.205 | 0.326 | 7.565 | 1.227 | 0.648-2.325 | 0.142 | |
Whole | 0.699 | 0.762 | 7.418 | 2.011 | 0.452-8.954 | 0.221 | |
Belching | Proximal | 0.023 | 0.376 | 7.488 | 1.023 | 0.490-2.138 | 0.172 |
Distal | 0.745 | 0.223 | 12.473 | 2.106 | 1.360-3.260 | 0.031 | |
Whole | -0.583 | 0.515 | 9.304 | 0.558 | 0.203-1.531 | 0.086 | |
Early satiety | Proximal | -0.467 | 0.718 | 8.471 | 0.627 | 0.153-2.561 | 0.096 |
Distal | 0.461 | 0.202 | 13.845 | 1.585 | 1.067-2.355 | 0.026 | |
Whole | -0.028 | 0.486 | 8.737 | 0.972 | 0.375-2.520 | 0.093 |
Table 5 Comparison of total symptom scores of patients before and after treatment
Groups | Before treatment | After treatment | Q value | P value |
H. pylori treatment group (n = 21) | 10.14 ± 4.02 | 5.15 ± 2.27 | 4.953 | 0.000 |
Conventional treatment group (n = 21) | 11.01 ± 3.92 | 7.02 ± 3.04 | 3.686 | 0.001 |
H. pylori-negative group (n = 28) | 11.61 ± 4.81 | 4.93 ± 3.22 | 6.107 | 0.000 |
Table 6 Comparison of gastric half-emptying time (min) of patients after treatment
Groups | Gastric half-emptying time at the proximal end | Gastric half-emptying time at the distal end | Gastric half-emptying time at whole gastric region |
(1) H. pylori treatment group (n = 21) | 74.0 ± 12.4 | 87.7 ± 13.4 | 80.3 ± 14.4 |
(2) Conventional treatment group (n = 21) | 83.1 ± 15.8 | 97.5 ± 15.1 | 91.9 ± 17.2 |
(3) H. pylori-negative group (n = 28) | 73.6 ± 11.7 | 88.3 ± 15.4 | 79.8 ± 15.9 |
F value | 3.211 | 3.143 | 3.188 |
P value | 0.004 | 0.019 | 0.007 |
(1):(2) Q value | 2.076 | 2.225 | 2.37 |
P value | 0.044 | 0.032 | 0.023 |
(1):(3) Q value | 0.115 | 0.143 | 0.107 |
P value | 0.909 | 0.887 | 0.915 |
(3):(2) Q value | 2.317 | 2.087 | 2.516 |
P value | 0.025 | 0.042 | 0.015 |
- Citation: Zhang CL, Geng CH, Yang ZW, Li YL, Tong LQ, Gao P, Gao YQ. Changes in patients’ symptoms and gastric emptying after Helicobacter pylori treatment. World J Gastroenterol 2016; 22(18): 4585-4593
- URL: https://www.wjgnet.com/1007-9327/full/v22/i18/4585.htm
- DOI: https://dx.doi.org/10.3748/wjg.v22.i18.4585