Correlation between Helicobacter pylori-associated gastric diseases and colorectal neoplasia

Table 1 Clinical indications for esophago-gastro-duodenoscopy and colonoscopy n (%)

Indication for EGD and colonoscopy	EGD	Colonoscopy
Abdominal discomfort	78 (33.5)	65 (27.9)
Diarrhea	26 (11.2)	47 (20.2)
Hematochezia	12 (5.2)	34 (14.6)
Weight loss	10 (4.3)	13 (5.6)
Others	58 (24.9)	39 (16.7)
Dyspepsia	33 (14.2)
Reflux esophagitis	42 (18.0)
Emesis	21 (9.0)
Colorectal cancer screening		25 (10.7)
Polypectomy following-up		24 (10.3)

EGD: Esophago-gastro-duodenoscopy.

Table 2 Correlation between Helicobacter pylori-associated gastritis and colorectal neoplasia n (%)

Parameter	Total number of patients (n = 233)	H. pylori-associated gastritis	Control group 1	OR	95%CI	P value
Age	56.85	52.72 ± 11.37	56.42 ± 14.90	-	-	-
Male	164	27 (16.5)	48 (29.3)	1.000	-	-
Female	69	9 (13.0)	36 (52.2)	0.444	0.186-1.060	0.064
Control group 2	95	10 (10.5)	40 (42.1)	1.000	-	-
Adenoma without HGIEN	92	18 (19.6)	30 (32.6)	2.400	0.969-5.941	0.055
Adenoma with HGIEN	16	4 (25.0)	3 (18.8)	5.333	1.025-27.758	0.054
Adenocarcinoma	27	4 (14.8)	11 (40.7)	1.455	0.382-5.543	0.721
Polyp number
1-3	106	16 (15.1)	36 (34.0)	1.778	0.716-4.414	0.212
4-9	46	10 (21.7)	14 (30.4)	2.857	0.983-8.306	0.049
10+	20	3 (15.0)	9 (45.0)	1.333	0.304-5.852	0.703
Adenoma size (mm)
0-9	82	15 (18.3)	25 (30.5)	2.400	0.934-6.165	0.066
10-19	30	5 (16.7)	9 (30.0)	2.222	0.609-8.108	0.286
20+	16	4 (25.0)	7 (43.8)	2.286	0.558-9.366	0.256
Polyp location
Rectum	79	14 (17.7)	33 (41.8)	1.697	0.667-4.315	0.264
Sigmoid colon	77	12 (15.6)	22 (28.6)	2.182	0.813-5.856	0.118
Descending colon	64	13 (20.3)	19 (29.7)	2.737	1.018-7.357	0.043
Transverse colon	55	11 (20.0)	17 (30.9)	2.588	0.927-7.230	0.065
Ascending colon	57	11 (19.3)	18 (31.6)	2.444	0.880-6.787	0.082

HGIEN: High-grade intraepithelial neoplasia; H. pylori: Helicobacter pylori.

Table 3 Correlation between gastric intestinal metaplasia and colorectal neoplasia n (%)

Parameter	Total number of patients (n = 233)	Gastric intestinal metaplasia	Control group 1	OR	95%CI	P value
Age	56.85	58.39 ± 7.34	56.42 ± 14.90	-	-	-
Male	164	44 (26.8)	48 (29.3)	1.000	-	-
Female	69	15 (21.7)	36 (52.2)	0.455	0.219-0.941	0.032
Control group 2	95	29 (30.5)	40 (42.1)	1.000	-	-
Adenoma without HGIEN	92	19 (20.7)	30 (32.6)	0.874	0.414-1.845	0.723
Adenoma with HGIEN	16	7 (43.8)	3 (18.8)	3.218	0.767-13.509	0.172
Adenocarcinoma	27	3 (11.1)	11 (40.7)	0.376	0.096-1.470	0.149
Polyp number
1-3	106	30 (28.3)	36 (34.0)	1.149	0.582-2.270	0.688
4-9	46	12 (26.1)	14 (30.4)	1.182	0.477-2.929	0.717
10+	20	5 (25.0)	9 (45.0)	0.766	0.232-2.527	0.661
Adenoma size (mm)
0-9	82	23 (28.0)	25 (30.5)	1.269	0.605-2.663	0.528
10-19	30	10 (33.3)	9 (30.0)	1.533	0.553-4.248	0.410
20+	16	1 (6.3)	7 (43.8)	0.197	0.023-1.690	0.140
Polyp location
Rectum	79	19 (24.1)	33 (41.8)	0.794	0.379-1.664	0.541
Sigmoid colon	77	24 (31.2)	22 (28.6)	1.505	0.710-3.187	0.285
Descending colon	64	17 (26.6)	19 (29.7)	1.234	0.549-2.775	0.611
Transverse colon	55	14 (25.5)	17 (30.9)	1.136	0.484-2.668	0.770
Ascending colon	57	12 (21.1)	18 (31.6)	0.920	0.384-2.201	0.851

HGIEN: High-grade intraepithelial neoplasia.

Table 4 Correlation between gastric intraepithelial neoplasia and colorectal neoplasia n (%)

Parameter	Total number of patients (n = 233)	Gastric intraepithelial neoplasia	Control group 1	OR	95%CI	P value
Age	56.85	57.68 ± 11.24	56.42 ± 14.90	-	-	-
Male	164	32 (19.5)	48 (29.3)	1.000	-	-
Female	69	5 (7.2)	36 (52.2)	0.208	0.074-0.588	0.002
Control group 2	95	9 (9.5)	40 (42.1)	1.000	-	-
Adenoma without HGIEN	92	21 (22.8)	30 (32.6)	3.111	1.248-7.753	0.013
Adenoma with HGIEN	16	1 (6.3)	3 (18.8)	1.481	0.138-15.941	1.000
Adenocarcinoma	27	5 (18.5)	11 (40.7)	2.020	0.561-7.272	0.306
Polyp number
1-3	106	17 (16.0)	36 (34.0)	2.099	0.832-5.293	0.112
4-9	46	10 (21.7)	14 (30.4)	3.175	1.071-9.413	0.033
10+	20	3 (15.0)	9 (45.0)	1.481	0.333-6.596	0.689
Adenoma size (mm)
0-9	82	16 (19.5)	25 (30.5)	2.844	1.092-7.410	0.029
10-19	30	4 (13.3)	9 (30.0)	1.975	0.496-7.868	0.444
20+	16	3 (18.8)	7 (43.8)	1.905	0.411-8.829	0.409
Polyp location
Rectum	79	12 (15.2)	33 (41.8)	1.616	0.607-4.304	0.335
Sigmoid colon	77	16 (20.8)	22 (28.6)	3.232	1.227-8.512	0.015
Descending colon	64	14 (21.9)	19 (29.7)	3.275	1.205-8.899	0.017
Transverse colon	55	13 (23.6)	17 (30.9)	3.399	1.223-9.443	0.016
Ascending colon	57	13 (22.8)	18 (31.6)	3.210	1.162-8.864	0.021

HGIEN: High-grade intraepithelial neoplasia.

Table 5 Correlation between gastric adenocarcinoma and colorectal neoplasia n (%)

Parameter	Total number of patients (n = 233)	Gastric adenocarcinoma	Control group 1	OR	95%CI	P value
Age	56.85	62.36 ± 16.31	56.42 ± 14.90	-	-	-
Male	164	10 (6.1)	48 (29.3)	1.000	-	-
Female	69	4 (5.8)	36 (52.2)	0.533	0.155-1.838	0.314
Control group 2	95	5 (5.3)	40 (42.1)	1.000	-	-
Adenoma without HGIEN	92	4 (4.3)	30 (32.6)	1.067	0.264-4.314	1.000
Adenoma with HGIEN	16	1 (6.3)	3 (18.8)	2.667	0.231-30.800	0.418
Adenocarcinoma	27	3 (11.1)	11 (40.7)	2.182	0.450-10.585	0.379
Polyp number
1-3	106	5 (4.7)	36 (34.0)	1.111	0.297-4.155	1.000
4-9	46	1 (2.2)	14 (30.4)	0.571	0.061-5.323	1.000
10+	20	0 (0.0)	9 (45.0)	-	-	-
Adenoma size (mm)
0-9	82	3 (3.7)	25 (30.5)	0.960	0.211-4.372	1.000
10-19	30	2 (6.7)	9 (30.0)	1.778	0.296-10.671	0.614
20+	16	1 (6.3)	7 (43.8)	1.143	0.115-11.311	1.000
Polyp location
Rectum	79	2 (2.5)	33 (41.8)	0.485	0.088-2.663	0.459
Sigmoid colon	77	3 (3.9)	22 (28.6)	1.091	0.238-5.003	1.000
Descending colon	64	1 (1.6)	19 (29.7)	0.421	0.046-3.859	0.657
Transverse colon	55	1 (1.8)	17 (30.9)	0.471	0.051-4.336	0.664
Ascending colon	57	3 (5.3)	18 (31.6)	1.333	0.287-6.192	0.702

HGIEN: High-grade intraepithelial neoplasia.