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©The Author(s) 2016.
World J Gastroenterol. May 14, 2016; 22(18): 4576-4584
Published online May 14, 2016. doi: 10.3748/wjg.v22.i18.4576
Published online May 14, 2016. doi: 10.3748/wjg.v22.i18.4576
Table 1 Clinical indications for esophago-gastro-duodenoscopy and colonoscopy n (%)
Indication for EGD and colonoscopy | EGD | Colonoscopy |
Abdominal discomfort | 78 (33.5) | 65 (27.9) |
Diarrhea | 26 (11.2) | 47 (20.2) |
Hematochezia | 12 (5.2) | 34 (14.6) |
Weight loss | 10 (4.3) | 13 (5.6) |
Others | 58 (24.9) | 39 (16.7) |
Dyspepsia | 33 (14.2) | |
Reflux esophagitis | 42 (18.0) | |
Emesis | 21 (9.0) | |
Colorectal cancer screening | 25 (10.7) | |
Polypectomy following-up | 24 (10.3) |
Table 2 Correlation between Helicobacter pylori-associated gastritis and colorectal neoplasia n (%)
Parameter | Total number of patients (n = 233) | H. pylori-associated gastritis | Control group 1 | OR | 95%CI | P value |
Age | 56.85 | 52.72 ± 11.37 | 56.42 ± 14.90 | - | - | - |
Male | 164 | 27 (16.5) | 48 (29.3) | 1.000 | - | - |
Female | 69 | 9 (13.0) | 36 (52.2) | 0.444 | 0.186-1.060 | 0.064 |
Control group 2 | 95 | 10 (10.5) | 40 (42.1) | 1.000 | - | - |
Adenoma without HGIEN | 92 | 18 (19.6) | 30 (32.6) | 2.400 | 0.969-5.941 | 0.055 |
Adenoma with HGIEN | 16 | 4 (25.0) | 3 (18.8) | 5.333 | 1.025-27.758 | 0.054 |
Adenocarcinoma | 27 | 4 (14.8) | 11 (40.7) | 1.455 | 0.382-5.543 | 0.721 |
Polyp number | ||||||
1-3 | 106 | 16 (15.1) | 36 (34.0) | 1.778 | 0.716-4.414 | 0.212 |
4-9 | 46 | 10 (21.7) | 14 (30.4) | 2.857 | 0.983-8.306 | 0.049 |
10+ | 20 | 3 (15.0) | 9 (45.0) | 1.333 | 0.304-5.852 | 0.703 |
Adenoma size (mm) | ||||||
0-9 | 82 | 15 (18.3) | 25 (30.5) | 2.400 | 0.934-6.165 | 0.066 |
10-19 | 30 | 5 (16.7) | 9 (30.0) | 2.222 | 0.609-8.108 | 0.286 |
20+ | 16 | 4 (25.0) | 7 (43.8) | 2.286 | 0.558-9.366 | 0.256 |
Polyp location | ||||||
Rectum | 79 | 14 (17.7) | 33 (41.8) | 1.697 | 0.667-4.315 | 0.264 |
Sigmoid colon | 77 | 12 (15.6) | 22 (28.6) | 2.182 | 0.813-5.856 | 0.118 |
Descending colon | 64 | 13 (20.3) | 19 (29.7) | 2.737 | 1.018-7.357 | 0.043 |
Transverse colon | 55 | 11 (20.0) | 17 (30.9) | 2.588 | 0.927-7.230 | 0.065 |
Ascending colon | 57 | 11 (19.3) | 18 (31.6) | 2.444 | 0.880-6.787 | 0.082 |
Table 3 Correlation between gastric intestinal metaplasia and colorectal neoplasia n (%)
Parameter | Total number of patients (n = 233) | Gastric intestinal metaplasia | Control group 1 | OR | 95%CI | P value |
Age | 56.85 | 58.39 ± 7.34 | 56.42 ± 14.90 | - | - | - |
Male | 164 | 44 (26.8) | 48 (29.3) | 1.000 | - | - |
Female | 69 | 15 (21.7) | 36 (52.2) | 0.455 | 0.219-0.941 | 0.032 |
Control group 2 | 95 | 29 (30.5) | 40 (42.1) | 1.000 | - | - |
Adenoma without HGIEN | 92 | 19 (20.7) | 30 (32.6) | 0.874 | 0.414-1.845 | 0.723 |
Adenoma with HGIEN | 16 | 7 (43.8) | 3 (18.8) | 3.218 | 0.767-13.509 | 0.172 |
Adenocarcinoma | 27 | 3 (11.1) | 11 (40.7) | 0.376 | 0.096-1.470 | 0.149 |
Polyp number | ||||||
1-3 | 106 | 30 (28.3) | 36 (34.0) | 1.149 | 0.582-2.270 | 0.688 |
4-9 | 46 | 12 (26.1) | 14 (30.4) | 1.182 | 0.477-2.929 | 0.717 |
10+ | 20 | 5 (25.0) | 9 (45.0) | 0.766 | 0.232-2.527 | 0.661 |
Adenoma size (mm) | ||||||
0-9 | 82 | 23 (28.0) | 25 (30.5) | 1.269 | 0.605-2.663 | 0.528 |
10-19 | 30 | 10 (33.3) | 9 (30.0) | 1.533 | 0.553-4.248 | 0.410 |
20+ | 16 | 1 (6.3) | 7 (43.8) | 0.197 | 0.023-1.690 | 0.140 |
Polyp location | ||||||
Rectum | 79 | 19 (24.1) | 33 (41.8) | 0.794 | 0.379-1.664 | 0.541 |
Sigmoid colon | 77 | 24 (31.2) | 22 (28.6) | 1.505 | 0.710-3.187 | 0.285 |
Descending colon | 64 | 17 (26.6) | 19 (29.7) | 1.234 | 0.549-2.775 | 0.611 |
Transverse colon | 55 | 14 (25.5) | 17 (30.9) | 1.136 | 0.484-2.668 | 0.770 |
Ascending colon | 57 | 12 (21.1) | 18 (31.6) | 0.920 | 0.384-2.201 | 0.851 |
Table 4 Correlation between gastric intraepithelial neoplasia and colorectal neoplasia n (%)
Parameter | Total number of patients (n = 233) | Gastric intraepithelial neoplasia | Control group 1 | OR | 95%CI | P value |
Age | 56.85 | 57.68 ± 11.24 | 56.42 ± 14.90 | - | - | - |
Male | 164 | 32 (19.5) | 48 (29.3) | 1.000 | - | - |
Female | 69 | 5 (7.2) | 36 (52.2) | 0.208 | 0.074-0.588 | 0.002 |
Control group 2 | 95 | 9 (9.5) | 40 (42.1) | 1.000 | - | - |
Adenoma without HGIEN | 92 | 21 (22.8) | 30 (32.6) | 3.111 | 1.248-7.753 | 0.013 |
Adenoma with HGIEN | 16 | 1 (6.3) | 3 (18.8) | 1.481 | 0.138-15.941 | 1.000 |
Adenocarcinoma | 27 | 5 (18.5) | 11 (40.7) | 2.020 | 0.561-7.272 | 0.306 |
Polyp number | ||||||
1-3 | 106 | 17 (16.0) | 36 (34.0) | 2.099 | 0.832-5.293 | 0.112 |
4-9 | 46 | 10 (21.7) | 14 (30.4) | 3.175 | 1.071-9.413 | 0.033 |
10+ | 20 | 3 (15.0) | 9 (45.0) | 1.481 | 0.333-6.596 | 0.689 |
Adenoma size (mm) | ||||||
0-9 | 82 | 16 (19.5) | 25 (30.5) | 2.844 | 1.092-7.410 | 0.029 |
10-19 | 30 | 4 (13.3) | 9 (30.0) | 1.975 | 0.496-7.868 | 0.444 |
20+ | 16 | 3 (18.8) | 7 (43.8) | 1.905 | 0.411-8.829 | 0.409 |
Polyp location | ||||||
Rectum | 79 | 12 (15.2) | 33 (41.8) | 1.616 | 0.607-4.304 | 0.335 |
Sigmoid colon | 77 | 16 (20.8) | 22 (28.6) | 3.232 | 1.227-8.512 | 0.015 |
Descending colon | 64 | 14 (21.9) | 19 (29.7) | 3.275 | 1.205-8.899 | 0.017 |
Transverse colon | 55 | 13 (23.6) | 17 (30.9) | 3.399 | 1.223-9.443 | 0.016 |
Ascending colon | 57 | 13 (22.8) | 18 (31.6) | 3.210 | 1.162-8.864 | 0.021 |
Table 5 Correlation between gastric adenocarcinoma and colorectal neoplasia n (%)
Parameter | Total number of patients (n = 233) | Gastric adenocarcinoma | Control group 1 | OR | 95%CI | P value |
Age | 56.85 | 62.36 ± 16.31 | 56.42 ± 14.90 | - | - | - |
Male | 164 | 10 (6.1) | 48 (29.3) | 1.000 | - | - |
Female | 69 | 4 (5.8) | 36 (52.2) | 0.533 | 0.155-1.838 | 0.314 |
Control group 2 | 95 | 5 (5.3) | 40 (42.1) | 1.000 | - | - |
Adenoma without HGIEN | 92 | 4 (4.3) | 30 (32.6) | 1.067 | 0.264-4.314 | 1.000 |
Adenoma with HGIEN | 16 | 1 (6.3) | 3 (18.8) | 2.667 | 0.231-30.800 | 0.418 |
Adenocarcinoma | 27 | 3 (11.1) | 11 (40.7) | 2.182 | 0.450-10.585 | 0.379 |
Polyp number | ||||||
1-3 | 106 | 5 (4.7) | 36 (34.0) | 1.111 | 0.297-4.155 | 1.000 |
4-9 | 46 | 1 (2.2) | 14 (30.4) | 0.571 | 0.061-5.323 | 1.000 |
10+ | 20 | 0 (0.0) | 9 (45.0) | - | - | - |
Adenoma size (mm) | ||||||
0-9 | 82 | 3 (3.7) | 25 (30.5) | 0.960 | 0.211-4.372 | 1.000 |
10-19 | 30 | 2 (6.7) | 9 (30.0) | 1.778 | 0.296-10.671 | 0.614 |
20+ | 16 | 1 (6.3) | 7 (43.8) | 1.143 | 0.115-11.311 | 1.000 |
Polyp location | ||||||
Rectum | 79 | 2 (2.5) | 33 (41.8) | 0.485 | 0.088-2.663 | 0.459 |
Sigmoid colon | 77 | 3 (3.9) | 22 (28.6) | 1.091 | 0.238-5.003 | 1.000 |
Descending colon | 64 | 1 (1.6) | 19 (29.7) | 0.421 | 0.046-3.859 | 0.657 |
Transverse colon | 55 | 1 (1.8) | 17 (30.9) | 0.471 | 0.051-4.336 | 0.664 |
Ascending colon | 57 | 3 (5.3) | 18 (31.6) | 1.333 | 0.287-6.192 | 0.702 |
- Citation: Qing Y, Wang M, Lin YM, Wu D, Zhu JY, Gao L, Liu YY, Yin TF. Correlation between Helicobacter pylori-associated gastric diseases and colorectal neoplasia. World J Gastroenterol 2016; 22(18): 4576-4584
- URL: https://www.wjgnet.com/1007-9327/full/v22/i18/4576.htm
- DOI: https://dx.doi.org/10.3748/wjg.v22.i18.4576