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©The Author(s) 2016.
World J Gastroenterol. May 14, 2016; 22(18): 4515-4528
Published online May 14, 2016. doi: 10.3748/wjg.v22.i18.4515
Published online May 14, 2016. doi: 10.3748/wjg.v22.i18.4515
Table 1 Number of protein expression changes in comparison between adjacent stages of colon carcinogenesis process
Comparison | Protein expression | |
Downregulated | Upregulated | |
AD:NC (113:114) | 113 | 86 |
CIS:AD (115:113) | 137 | 102 |
ICC:CIS (116:115) | 103 | 141 |
Table 2 Top 10 differential proteins (up-regulated and down-regulated) between different stages
No. | GN | Protein name | Cluster | AD:NC | CIS:NC | ICC:NC |
1 | DMBT1 | Deleted in malignant brain tumors 1 protein | 5 | 3.12 | 3.43 | 4.82 |
2 | S100A9 | Protein S100-A9 | 5 | 2.56 | 2.52 | 4.67 |
3 | CLC | Galectin-10 | 5 | 4.21 | 2.50 | 4.54 |
4 | S100A8 | Protein S100-A8 | 5 | 1.51 | 1.46 | 3.72 |
5 | MPO | Myeloperoxidase | 6 | 1.22 | 0.09 | 3.12 |
6 | OLFM4 | Olfactomedin-4 | 5 | 3.89 | 3.01 | 3.02 |
7 | LDHA | L-lactate dehydrogenase A chain | 5 | 1.93 | 3.69 | 2.92 |
8 | SERPINB5 | Serpin B5 | 5 | 4.32 | 2.69 | 2.78 |
9 | EPX | Eosinophil peroxidase | 5 | 3.16 | 2.82 | 2.73 |
10 | COL12A1 | Collagen alpha-1(XII) chain | 5 | 0.57 | 4.35 | 2.68 |
11 | TNC | Tenascin | 5 | -0.48 | 4.41 | 2.33 |
12 | HNRNPA1 | Heterogeneous nuclear ribonucleoprotein A1 | 5 | 2.69 | 3.55 | 2.16 |
13 | MUC2 | Mucin-2 | 2 | -0.80 | -5.21 | -0.39 |
14 | CA2 | Carbonic anhydrase 2 | 2 | -2.86 | -5.08 | -0.62 |
15 | DCN | Decorin | 4 | -3.67 | -2.03 | -1.06 |
16 | COL14A1 | Collagen alpha-1(XIV) chain | 2 | -4.25 | -3.42 | -1.06 |
17 | LUM | Lumican | 4 | -3.90 | -1.40 | -1.21 |
18 | CA1 | Carbonic anhydrase 1 | 2 | -2.63 | -4.96 | -1.74 |
19 | ITLN1 | Intelectin-1 | 2 | -2.18 | -5.00 | -1.91 |
20 | ASPN | Asporin | 4 | -3.59 | -1.36 | -1.91 |
21 | OGN | Mimecan | 2 | -4.35 | -4.71 | -2.29 |
22 | GSTP1 | Glutathione S-transferase P | 7 | -1.36 | -1.06 | -2.73 |
23 | CKB | Creatine kinase B-type | 2 | -1.26 | -2.98 | -2.76 |
24 | PFN1 | Profilin-1 | 7 | -0.47 | 0.30 | -2.84 |
25 | CHGA | Chromogranin-A | 2 | -3.44 | -4.84 | -3.20 |
26 | TPI1 | Triosephosphate isomerase | 7 | -0.88 | -2.32 | -3.75 |
- Citation: Peng F, Huang Y, Li MY, Li GQ, Huang HC, Guan R, Chen ZC, Liang SP, Chen YH. Dissecting characteristics and dynamics of differentially expressed proteins during multistage carcinogenesis of human colorectal cancer. World J Gastroenterol 2016; 22(18): 4515-4528
- URL: https://www.wjgnet.com/1007-9327/full/v22/i18/4515.htm
- DOI: https://dx.doi.org/10.3748/wjg.v22.i18.4515