Missing metastases as a model to challenge current therapeutic algorithms in colorectal liver metastases

Table 1 Incidence of missing liver metastases and rates of local cure as defined by complete pathological response or absence of in situ recurrence on follow-up

Ref.	Year	Incidence1	CPR2	Sustained local clinical response3
Elias et al[39]	2004	10%	-	-
Benoist et al[40]	2006	6%	20%	26%
Elias et al[41]	2007	-	-	62%
Tanaka et al[42]	2009	-	100%	59%
Auer et al[43]	2010	9%	65%	62%
van Vledder et al[45]	2010	24%	39%	53%
Ferrero et al[46]	2012	11%	-	39%
Ono et al[47]	2012	-	100%	82%

¹Incidence calculated as the number of patients with at least 1 missing liver metastases (MLM) among the total group of patients evaluated in the study;

²Complete pathologic response as defined by the absence of residual cancer cells when the initial site of MLM was resected;

³Sustained clinical response as defined as the absence of local recurrence at the initial site when MLM was left unresected.