Comparison of 5-hydroxytryptophan signaling pathway characteristics in diarrhea-predominant irritable bowel syndrome and ulcerative colitis

doi:10.3748/wjg.v22.i12.3451

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Mar 28, 2016 (publication date) through Nov 26, 2024

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Mar 28, 2016; 22(12): 3451-3459
Published online Mar 28, 2016. doi: 10.3748/wjg.v22.i12.3451

Table 1 Comparison of age, sex and duration of remission

	Healthy group	UC remission group	IBS-D group
Cases	30	33	30
Age (yr), mean age	23-62, (42.5 ± 19.5)	22-56, (39 ± 17)	18-60, (39 ± 21)
Sex	15 females, 15 males	15 females, 18 males	16 males, 14 females
Duration (yr)	None	1.8 ± 18.2	1.6 ± 20.4

UC: Ulcerative colitis; IBS-D: Diarrhea-predominant irritable bowel syndrome.

Table 2 Comparisons of changes in the gastrointestinal symptom scores of patients in each group (mean ± SD)

Symptom	Normal	IBS-D	UC in remission
Abdominal pain or discomfort	0.25 ± 0.05	1.84 ± 0.67^a	2.84 ± 0.81^b
Stool frequency	0.55 ± 0.05	1.46 ± 0.58^a	2.34 ± 0.76^b
Stool	0.75 ± 0.05	1.44 ± 0.67^a	1.89 ± 0.87^b
Mucus	0.10 ± 0.03	1.04 ± 0.84^b	1.58 ± 0.67^b
Defecation	0.55 ± 0.05	1.06 ± 0.74	1.86 ± 0.86^b
Total score	1.75 ± 0.23	6.83 ± 1.86^a	9.51 ± 1.91^b

^aP < 0.05,

^bP < 0.01 vs normal. UC: Ulcerative colitis; IBS-D: Diarrhea-predominant irritable bowel syndrome.

Table 3 Testing of anorectal motility and rectal visceral sensation in each group

	Normal	IBS-D	UC in remission
Initial sensory threshold (mL)	50.18 ± 4.19	23.91 ± 10.15^a	20.10 ± 9.17^b
Defecation threshold (mL)	69.15 ± 10.75	35.17 ± 12.71^a	21.28 ± 10.32^b
Pain threshold (mL)	105.90 ± 20.15	70.10 ± 11.25^a	50.33 ± 12.30^b
Maximum compliance (mL/mmHg)	4.95 ± 1.81	5.02 ± 1.75	4.98 ± 1.91
Resting pressure (mmHg)	62.15 ± 15.21	65.54 ± 13.15	63.27 ± 10.15
Relaxation pressure (mmHg)	105.15 ± 60.15	140.50 ± 55.50^a	138.69 ± 52.82^a
Relaxation pressure (mmHg)	43.18 ± 22.50	45.15 ± 20.65	46.10 ± 19.97

^aP < 0.05,

^bP < 0.01 vs normal. UC: Ulcerative colitis; IBS-D: Diarrhea-predominant irritable bowel syndrome.

Table 4 Comparison of 5-HT and 5-HIAA concentrations in each group (mean ± SD)

	5-HT (nmol/L)	5-HIAA (nmol/L)
Normal	10.55 ± 1.35	1.15 ± 0.15
IBS-D	35.31 ± 2.15^a	8.50 ± 1.50^a
UC in remission	33.85 ± 1.55^a	8.15 ± 1.35^a

^aP < 0.05 vs normal. UC: Ulcerative colitis; IBS-D: Diarrhea-predominant irritable bowel syndrome.

Table 5 TPH1 protein expression in the colonic mucosa of patients in each group

Group	TPH1
Normal	0.032 ± 0.015
IBS-D	0.183 ± 0.034^a
UC in remission	0.185 ± 0.027^a

^aP < 0.05 vs normal. UC: Ulcerative colitis; IBS-D: Diarrhea-predominant irritable bowel syndrome.

Table 6 5-HT3R, 4R, and 7R receptor mRNA expression levels in each group

Group	5-HT3R	5-HT4R	5-HT7R
Normal	0.086 ± 0.05	0.155 ± 0.0913	0.1097 ± 0.0405
IBS-D	0.499 ± 0.012^a	0.013 ± 0.067^a	0.0911 ± 0.0501^a
UC in remission	0.954 ± 0.022^a	0.015 ± 0.059^a	0.1711 ± 0.0845^a

^aP < 0.05 vs normal. UC: Ulcerative colitis; IBS-D: Diarrhea-predominant irritable bowel syndrome.

Table 7 Comparison of serotonin transporter protein gray values

Group	Cases	Mean gray value
Normal	30	154.8 ± 10.5
IBS-D	30	169.1 ± 10.1^a
Ulcerative colitis	33	173.0 ± 8.4^a

^aP < 0.05 vs normal. IBS-D: Diarrhea-predominant irritable bowel syndrome.

Citation: Yu FY, Huang SG, Zhang HY, Ye H, Chi HG, Zou Y, Lv RX, Zheng XB. Comparison of 5-hydroxytryptophan signaling pathway characteristics in diarrhea-predominant irritable bowel syndrome and ulcerative colitis. World J Gastroenterol 2016; 22(12): 3451-3459
URL: https://www.wjgnet.com/1007-9327/full/v22/i12/3451.htm
DOI: https://dx.doi.org/10.3748/wjg.v22.i12.3451