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©The Author(s) 2016.
World J Gastroenterol. Mar 28, 2016; 22(12): 3363-3371
Published online Mar 28, 2016. doi: 10.3748/wjg.v22.i12.3363
Published online Mar 28, 2016. doi: 10.3748/wjg.v22.i12.3363
Table 1 Body weight, vasopressin and serum sodium in baseline conditions in cirrhotic rats prior to receiving tolvaptan (3 mg/kg), tolvaptan (5 mg/kg) or vehicle
1 d | 2 d | 3 d | 4 d | 5 d | ||
Body weight (g) | Vehicle | 486.7 ± 12.57 (5) | 492.1 ± 10.12 (5) | 472.8 ± 18.21 (5) | 475.2 ± 9.21 (5) | 482.8 ± 13.24 (5) |
Tolvaptan (3 mg/kg) | 502.3 ± 11.91 (6) | 487.3 ± 12.43 (6) | 465.6 ± 16.59 (6) | 465.6 ± 13.24 (6) | 476.3 ± 16.00 (5) | |
Tolvaptan (5 mg/kg) | 493.4 ± 16.34 (6) | 485.2 ± 20.21 (6) | 490.1 ± 13.12 (6) | 472.1 ± 12.12 (6) | 490.1 ± 11.12 (6) | |
Vasopressin(pg/L) | Vehicle | 13.25 ± 1.24 (5) | 14.15 ± 1.41 (5) | 15.44 ± 1.38 (5) | 14.99 ± 0.94 (5) | 13.05 ± 0.85 (5) |
Tolvaptan (3 mg/kg) | 15.29 ± 0.93 (6) | 13.37 ± 1.22 (6) | 16.87 ± 0.73 (6) | 15.16 ± 1.17 (6) | 14.33 ± 0.99 (5) | |
Tolvaptan (5 mg/kg) | 14.85 ± 1.39 (6) | 14.23 ± 0.81 (6) | 15.12 ± 1.21 (6) | 13.21 ± 1.21 (6) | 15.23 ± 0.81 (6) | |
Serum sodium (mol/L) | Vehicle | 141.2 ± 1.31 (5) | 141.2 ± 1.11 (5) | 139.2 ± 0.75 (5) | 140.1 ± 0.92 (5) | 140.2 ± 1.31 (5) |
Tolvaptan (3 mg/kg) | 139.2 ± 1.27 (6) | 141.3 ± 1.20 (6) | 138.2 ± 1.85 (6) | 140.1 ± 1.23 (6) | 138.2 ± 1.87 (5) | |
Tolvaptan (5 mg/kg) | 141.2 ± 1.21 (6) | 140.9 ± 1.12 (6) | 142.2 ± 1.22 (6) | 138.1 ± 2.21 (6) | 139.1 ± 1.55 (6) |
Table 2 Body weight, vasopressin, and serum sodium in cirrhotic rats after tolvaptan (3 mg/kg), tolvaptan (5 mg/kg), or vehicle
1 d | 2 d | 3 d | 4 d | 5 d | ||
Body weight (g) | Vehicle | 492.6 ± 11.22 (5) | 498.5 ± 12.21 (5) | 490.3 ± 16.21 (5) | 500.1 ± 16.21 (5) | 493.1 ± 11.12 (5) |
Tolvaptan (3 mg/kg) | 482.2 ± 20.21 (5) | 466.2 ± 10.19 (6)a | 450.1 ± 18.21 (5)a | 443.1 ± 20.12 (6)a | 440.1 ± 20.12 (5)a | |
Tolvaptan (5 mg/kg) | 460.2 ± 12.31 (5)a | 455.1 ± 16.12 (5)a | 440.2 ± 23.12 (6)a | 437.3 ± 22.21 (5)a | 446.1 ± 21.21 (4)a | |
Vasopressin (pg/L) | Vehicle | 12.97 ± 0.92 (5) | 13.81 ± 1.30 (5) | 15.91 ± 0.89 (5) | 16.97 ± 1.38 (5) | 14.02 ± 0.98 (5) |
Tolvaptan (3 mg/kg) | 12.25 ± 0.82 (5) | 11.41 ± 0.62 (6) | 10.21 ± 0.91 (5)a | 9.77 ± 1.21 (6)a | 7.12 ± 1.32 (5)b | |
Tolvaptan (5 mg/kg) | 12.01 ± 1.21 (5) | 10.12 ± 0.92 (5)a | 8.12 ± 1.22 (6)a | 7.01 ± 1.63 (5)b | 7.33 ± 1.13 (4)a | |
Serum sodium (mol/L) | Vehicle | 140.2 ± 1.25 (5) | 140.2 ± 1.51 (5) | 141.2 ± 0.65 (5) | 141.1 ± 1.61 (5) | 142.2 ± 0.81 (5) |
Tolvaptan (3 mg/kg) | 143.2 ± 2.32 (5) | 144.2 ± 1.17 (6)a | 146.1 ± 1.13 (5)a | 147.2 ± 2.11 (6)b | 146.1 ± 2.47 (5)a | |
Tolvaptan (5 mg/kg) | 144.1 ± 1.22 (5)a | 147.1 ± 2.51 (5)a | 147.9 ± 2.21 (6)a | 146.2 ± 1.71 (5)a | 147.2 ± 1.12 (4)b |
- Citation: Chen C, Chen RP, Lin HH, Zhang WY, Huang XL, Huang ZM. Tolvaptan regulates aquaporin-2 and fecal water in cirrhotic rats with ascites. World J Gastroenterol 2016; 22(12): 3363-3371
- URL: https://www.wjgnet.com/1007-9327/full/v22/i12/3363.htm
- DOI: https://dx.doi.org/10.3748/wjg.v22.i12.3363