Copyright
©The Author(s) 2016.
World J Gastroenterol. Mar 14, 2016; 22(10): 3015-3022
Published online Mar 14, 2016. doi: 10.3748/wjg.v22.i10.3015
Published online Mar 14, 2016. doi: 10.3748/wjg.v22.i10.3015
Table 1 Comparison of patients’ characteristics and surgical outcomes n (%)
| LLR (n = 39) | OLR (n = 29) | P value | |
| Age (yr) | 69.4 ± 10.2 | 68.3 ± 8.1 | NS |
| Sex (Male/Female) | 26/13 | 22/7 | NS |
| HBV | 6 (15.4) | 4 (13.8) | NS |
| HCV | 19 (48.7) | 13 (44.8) | NS |
| Diagnosis | |||
| Hepatocellular carcinoma | 33 (84.6) | 22 (75.9) | |
| Intrahepatic cholangiocarcinoma | 2 (5.1) | 1 (3.4) | |
| Metastatic liver tumor | 2 (5.1) | 6 (20.7) | |
| Hemangioma | 2 (5.1) | 0 | |
| Body mass index (kg/m2) | 24.1 ± 4.1 | 23.9 ± 3.9 | NS |
| Tumor size (mm) | 27.3 ± 14.5 | 27.6 ± 11.6 | NS |
| Surgical outcome | |||
| Operation time (min) | 226.1 ± 117.2 | 292.8 ± 86.7 | 0.009 |
| Blood loss (mL) | 109.3 ± 162.0 | 406.9 ± 425.6 | 0.001 |
| Postoperative hospital stay (d) | 12.8 ± 10.4 | 23.6 ± 30.1 | 0.042 |
| Overall morbidity | 4 (10.2) | 7 (24.1) | NS |
| Grade I | 0 | 1 | |
| Grade II | 3 | 4 | |
| Grade III (a/b) | 1/0 | 1/1 | |
| Grade IV | 0 | 0 | |
| Grade V | 0 | 0 | |
| Bile leakage | 1 (2.7) | 2 (6.9) | NS |
Table 2 Comparison of patients’ characteristics and surgical outcomes in patients with obesity
| LLR (n = 12) | OLR (n = 10) | P value | |
| Patients’ characteristics | |||
| Age | 70.5 ± 9.4 | 67.1 ± 6.2 | NS |
| Sex (Male/Female) | 7/5 | 10/0 | 0.020 |
| HBV | 1 | 2 | NS |
| HCV | 7 | 2 | NS |
| Body mass index (kg/m2) | 29.0 ± 3.7 | 28.2 ± 2.3 | NS |
| Tumor size (mm) | 23.8 ± 8.7 | 26.0 ± 11.6 | NS |
| Liver weight (g) | 47.1 ± 35.5 | 60.8 ± 61.2 | NS |
| Surgical outcome | |||
| Operation time (min) | 241.3 ± 97.6 | 346.7 ± 83.8 | 0.014 |
| Blood loss (mL) | 128.3 ± 193.1 | 635.5 ± 655.1 | 0.039 |
| Postoperative hospital stay (d) | 11.6 ± 3.3 | 20.8 ± 15.4 | 0.094 |
| Complication, n (%) | 1 (8.3) | 1 (10) | NS |
| Biloma | 0 | 0 | NS |
Table 3 Univariate and multivariate analysis on prolonged operation time
| Operation time | Univariate | Multivariate | |||
| < 200 | ≥200 | P value | P value | OR (95%CI) | |
| Number of patients | 25 | 43 | |||
| Age (yr) | 71.5 ± 8.4 | 67.4 ± 9.6 | 0.082 | ||
| Sex (Male/Female) | 16/9 | 32/11 | 0.363 | ||
| Body mass index (kg/m2) | 22.7 ± 2.6 | 24.8 ± 4.5 | 0.019 | 0.024 | 1.259 (1.031-1.538) |
| HBV | 2 | 8 | 0.304 | ||
| HCV | 12 | 20 | 0.906 | ||
| Open liver resection < 0.001 | 3 | 26 | < 0.001 | < 0.001 | 16.244 (3.648-72.340) |
| Tumor size (mm) | 23.3 ± 9.9 | 29.8 ± 14.4 | 0.049 | 0.047 | 1.056 (1.001-1.114) |
| Total bilirubin (mg/dL) | 0.77 ± 0.28 | 0.79 ± 0.31 | 0.829 | ||
| Albumin (g/dL) | 3.94 ± 0.59 | 3.91 ± 0.46 | 0.848 | ||
| Prothrombin time (%) | 101.4 ± 21.9 | 98.2 ± 17.2 | 0.508 | ||
| Indocyanine green (%) | 11.8 ± 11.1 | 18.9 ± 14.8 | 0.042 | ||
| Aspartate transaminase (U/L) | 36.8 ± 20.5 | 39.1 ± 20.9 | 0.669 | ||
| Alanine transaminase (U/L) | 30.2 ± 22.8 | 33.3 ± 22.3 | 0.596 | ||
| γ-glutamy transpeptidase (U/L) | 57.5 ± 48.3 | 64.8 ± 51.3 | 0.567 | ||
| Alkaline phosphatase (U/L) | 315.6 ± 109.9 | 306.0 ± 105.5 | 0.725 | ||
| Cholinesterase (U/L) | 176.6 ± 127.0 | 188.5 ± 115.3 | 0.649 | ||
| White blood cell (/mm3) | 4342 ± 1383 | 4638 ± 1748 | 0.470 | ||
| Hemoglobin (g/dL) | 12.8 ± 1.9 | 13.1 ± 2.1 | 0.598 | ||
| Hematocrit (%) | 36.9 ± 7.3 | 39.0 ± 5.6 | 0.185 | ||
| Platelet count (× 103/mm3) | 14.5 ± 7.7 | 13.2 ± 6.0 | 0.433 | ||
Table 4 Univariate and multivariate analysis on increased blood loss
| Blood loss | Univariate | Multivariate | |||
| < 215 | ≥215 | P value | P value | OR (95%CI) | |
| Number of patients | 40 | 28 | |||
| Age (yr) | 68.5 ± 10.1 | 68.1 ± 4.5 | 0.558 | ||
| Sex (Male/Female) | 26/14 | 22/6 | 0.227 | ||
| Body mass index (kg/m2) | 23.1 ± 3.4 | 25.3 ± 4.5 | 0.027 | 0.035 | 1.233 (1.015-1.498) |
| HBV | 4 | 6 | 0.297 | ||
| HCV | 20 | 12 | 0.561 | ||
| Open liver resection | 8 | 21 | < 0.001 | < 0.001 | 27.736 (5.926-129.811) |
| Tumor size (mm) | 26.0 ± 11.4 | 29.4 ± 15.5 | 0.303 | ||
| Total bilirubin (mg/dL) | 0.76 ± 0.30 | 0.81 ± 0.30 | 0.490 | ||
| Albumin (g/dL) | 3.98 ± 0.55 | 3.84 ± 0.43 | 0.287 | ||
| Prothrombin time (%) | 103.2 ± 20.3 | 93.9 ± 15.6 | 0.046 | 0.030 | 0.947 (0.902-0.995) |
| Indocyanine green (%) | 13.4 ± 10.7 | 20.3 ± 16.9 | 0.044 | ||
| Aspartate transaminase (U/L) | 34.3 ± 19.8 | 43.9 ± 20.7 | 0.056 | ||
| Alanine transaminase (U/L) | 28.3 ± 19.6 | 37.6 ± 25.2 | 0.955 | ||
| γ-glutamy transpeptidase (U/L) | 52.6 ± 50.1 | 75.7 ± 47.4 | 0.060 | ||
| Alkaline phosphatase (U/L) | 310.1 ± 107.1 | 308.6 ± 107.3 | 0.955 | ||
| Cholinesterase (U/L) | 178.9 ± 130.0 | 191.6 ± 103.0 | 0.669 | ||
| White blood cell (/mm3) | 4339 ± 1540 | 4802 ± 1716 | 0.249 | ||
| Hemoglobin (g/dL) | 12.8 ± 1.9 | 13.4 ± 2.2 | 0.218 | ||
| Hematocrit (%) | 37.0 ± 6.5 | 40.0 ± 5.7 | 0.056 | ||
| Platelet count (× 103/mm3) | 14.7 ± 7.6 | 12.3 ± 4.6 | 0.114 | ||
- Citation: Uchida H, Iwashita Y, Saga K, Takayama H, Watanabe K, Endo Y, Yada K, Ohta M, Inomata M. Benefit of laparoscopic liver resection in high body mass index patients. World J Gastroenterol 2016; 22(10): 3015-3022
- URL: https://www.wjgnet.com/1007-9327/full/v22/i10/3015.htm
- DOI: https://dx.doi.org/10.3748/wjg.v22.i10.3015