Optimal initiation of Helicobacter pylori eradication in patients with peptic ulcer bleeding

Table 1 Baseline demographics of patients with peptic ulcer bleeding according to the time of Helicobacter pylori infection status confirmation n (%)

	Confirmation during hospitalization (n = 127)	Confirmation after discharge (n = 105)	P value
Male	94 (74.0)	78 (74.3)	1.000
Age mean ± SD (yr)	68.2 ± 14.1	67.6 ± 15.5	0.751
Disease			0.667
BGU	100 (78.7)	86 (81.9)
DU	10 (7.9)	9 (8.6)
BGU and DU	17 (13.4)	10 (9.5)
Stage of ulcers			0.045
Active stage	113 (89.0)	83 (79.0)
Healing stage	14 (11.0)	22 (21.0)
Endoscopic hemostasis			0.793
Yes	64 (50.4)	51 (48.6)
No	63 (49.6)	54 (51.4)
Methods for diagnosis of H. pylori infection			0.881
Histology	12 (9.4)	12 (11.4)
Rapid urease test	11 (8.7)	9 (8.6)
Both	104 (81.9)	84 (80.0)
Duration of hospitalization mean ± SD (d)	4.9 ± 1.5	4.3 ± 1.5	0.009
Specialty of the attending physician			0.461
Gastroenterology	119 (93.7)	95 (90.5)
Others	8 (6.3)	10 (9.5)

BGU: Benign gastric ulcer; DU: Duodenal ulcer; H. pylori: Helicobacter pylori; PUB: Peptic ulcer bleeding.

Table 2 Baseline demographics of patients with peptic ulcer bleeding who underwent Helicobacter pylori eradication therapy according to the time of eradication therapy initiation n (%)

	Eradication during hospitalization (n = 77)	Eradication at the OPC(n = 20)	P value
Male	59 (76.6)	17 (85.0)	0.550
Age mean ± SD (yr)	66.1 ± 13.9	59.5 ± 15.1	0.063
Disease			0.833
BGU	57 (74.0)	16 (80)
DU	9 (11.7)	1 (5.0)
BGU and DU	11 (14.3)	3 (15.0)
Eradication regimen			0.191
7-d triple therapy1	60 (77.9)	20 (100)
10-d triple therapy	2 (2.6)	0
14-d triple therapy	10 (13.0)	0
Others	5 (6.5)	0
Smoking			0.100
Current	22 (28.6)	7 (35.0)
Past	5 (6.5)	4 (20.0)
Never	50 (64.9)	9 (45.0)
Oral iron replacement during eradication therapy			0.113
Yes	30 (39.0)	4 (20.0)
No	47 (61.0)	16 (80.0)

¹Proton-pump inhibitor standard dose bid, clarithromycin 500 mg bid, and amoxicillin 1000 mg bid. BGU: Benign gastric ulcer; DU: Duodenal ulcer; H. pylori: Helicobacter pylori; OPC: Outpatient clinic; PUB: Peptic ulcer bleeding.

Table 3 Helicobacter pylori eradication rates according to the time of eradication therapy initiation in patients with peptic ulcer bleeding

	Eradication during hospitalization (n = 77)	Eradication at the OPC(n = 20)	P value
ITT analysis
Eradication rate	68.8%	60%	0.594
95%CI	58.2%-79.4%	36.5%-83.5%
PP analysis
Eradication rate	82.8%	80%	0.723
95%CI	73.3%-92.3%	57.1%-100%

BGU: Benign gastric ulcer; DU: Duodenal ulcer; H. pylori: Helicobacter pylori; ITT: Intention-to-treat; OPC: Outpatient clinic; PP: Per-protocol; PUB: Peptic ulcer bleeding.