Hypoxia-inducible factor-1 modulates upregulation of mutT homolog-1 in colorectal cancer

Table 1 Associations of tumor characteristics with mutT homolog-1 mRNA relative expression in colorectal cancer

Characteristics	n (%)	MTH-1
		means ± SD	P value
Total	84 (100)
Age (yr)
≤ 60	39 (46.43)	3.782 ± 4.017	0.3921
> 60	45 (53.57)	2.720 ± 1.993
Gender
Male	58 (69.05)	3.002 ± 2.609	0.2981
Female	26 (30.95)	4.146 ± 3.449
Differentiation degree
Well and moderate	52 (61.90)	3.549 ± 2.971	0.2091
Poor	32 (39.10)	2.666 ± 3.302
Tumor size (cm)
≤ 3	32 (38.10)	1.673 ± 1.342	0.0431
> 3	52 (61.90)	4.159 ± 3.593
Stage
I/II	51 (60.71)	2.098 ± 1.627	0.0232
III/IV	33 (29.29)	4.935 ± 4.028

¹One-way ANOVA test;

²Mann–Whitney U test. MTH-1: MutT homolog-1.

Table 2 Association analysis between mutT homolog-1 and hypoxia-inducible factor-1 expression in human colorectal cancer tissue

MTH-1	HIF-1α(n)		Total
	Positive	Negative
Positive	43	4	47
Negative	13	24	37
Total	56	28	84

R = 0.640; P < 0.001. MTH-1: MutT homolog-1; HIF-1α: Hypoxia-inducible factor-1α.