Feasible endoscopic therapy for early gastric cancer

Table 1 Clinical pathological features of 525 early gastric cancer cases and univariate analysis of risk factors for lymph node metastasis n (%)

Variables	Lymph node metastasis		P value
	Negative(n = 364)	Positive(n = 161)
Gender
Male	241 (73.5)	87 (26.5)	0.008
Female	123 (62.4)	74 (37.6)
Age (yr)
< 60	207 (67.2)	101 (32.8)	0.208
≥ 60	157 (72.4)	60 (27.6)
Tumor size (cm)
≤ 2	202 (76.5)	62 (23.5)	0.000
> 2	162 (62.1)	99 (37.9)
Invasion depth
Mucosa (T1a)	190 (81.5)	43 (18.5)	0.000
Submucosa (T1b)	174 (59.6)	118 (40.4)
Histology
Differentiated	144 (80.9)	34 (19.1)	0.000
Undifferentiated	220 (63.4)	127 (36.6)
Ulceration
Present	79 (65.8)	41 (34.2)	0.344
Absent	285 (70.4)	120 (29.6)
Lymphatic involvement
Present	11 (33.3)	22 (66.7)	0.000
Absent	353 (71.7)	139 (28.3)

Table 2 Multivariate analysis of risk factors of 525 early gastric cancer cases for lymph node metastasis

Variables	OR	95%CI	P value
Gender (female/male)	1.649	1.091-2.492	0.018
Tumor size (> 2 cm/ ≤ 2 cm)	1.803	1.201-2.706	0.004
Invasion depth (T1b/T1a)	2.566	1.671-3.941	0.000
Histology (undifferentiated/differentiated)	2.621	1.624-4.230	0.000
Lymphaticinvolvement (present/absent)	3.505	1.590-7.725	0.002

Table 3 Comprehensive analysis of 233 mucosal carcinomas (T1a) for lymph node metastasis n (%)

Gender	Tumor size (cm)	Lymphatic involvement	Histology	Lymph node metastasis
				Negative	Positive
Female (93)	≤ 2	Absent	Differentiated	14	0 (0)
			Undifferentiated	32	8 (20)
		Present	Differentiated	0	1 (100)
			Undifferentiated	0	0 (0)
	> 2	Absent	Differentiated	5	1 (16.7)
			Undifferentiated	17	15 (46.9)
		Present	Differentiated	0	0 (0)
			Undifferentiated	0	0 (0)
Male (140)	≤ 2	Absent	Differentiated	36	0 (0)
			Undifferentiated	31	9 (22.5)
		Present	Differentiated	0	0 (0)
			Undifferentiated	1	1 (50)
	> 2	Absent	Differentiated	28	2 (6.7)
			Undifferentiated	26	6 (18.75)
		Present	Differentiated	0	0 (0)
			Undifferentiated	0	0 (0)