Long-term outcomes after radical gastrectomy in gastric cancer patients with overt bleeding

Table 1 Patient proportion according to tumor location n (%)

	OB	Non-OB	P value
All			0.541
Resectable	141 (20.3)	554 (79.7)
Unresectable	54 (22.1)	190 (77.9)
Upper			0.136
Resectable	41 (22.9)	138 (77.1)
Unresectable	14 (15.2)	78 (84.8)
Middle			0.887
Resectable	17 (24.3)	53 (75.7)
Unresectable	9 (23.1)	30 (76.9)
Lower			0.038a
Resectable	83 (18.6)	363 (81.4)
Unresectable	31 (27.4)	82 (72.6)

^aP < 0.05, resectable vs unresectable. OB: Overt bleeding.

Table 2 Patient characteristics for the whole patient group and upper gastric cancer patients n (%)

	All			Upper gastric cancer
	Non-OB	OB	P value	Non-OB	OB	P value
Gender1			0.718			0.996
Male	352 (67.6)	87 (65.9)		94 (71.8)	28 (71.8)
Female	169 (32.4)	45 (34.1)		37 (28.2)	11 (28.2)
Age2	63.2 ± 11.6	62.2 ± 13.4	0.497	64.8 ± 10.6	62 ± 12.8	0.276
AJCC stage1			0.081			0.017a
I-II	240 (46.1)	72 (54.5)		46 (35.1)	22 (56.4)
III-IV	281 (53.9)	60 (45.5)		85 (64.9)	17 (43.6)
T category1			0.201			0.010a
T1-T2	163 (31.3)	49 (37.1)		17 (13)	12 (30.8)
T3-T4	358 (68.7)	83 (62.9)		114 (87)	27 (69.2)
Involved lymph nodes2	5.4 ± 7.8	4.7 ± 6.5	0.523	4.9 ± 5.9	4.2 ± 6.0	0.248
N category1			0.793			0.311
N0	187 (35.9)	49 (37.1)		36 (27.5)	14 (35.9)
N1-N3	334 (64.1)	83 (62.9)		95 (72.5)	25 (64.1)
Macroscopic (Borrmann) type1			0.357			0.036a
EGC	90 (17.5)	19 (14.4)		8 (6.1)	4 (10.3)
I	30 (5.8)	14 (10.6)		8 (6.1)	8 (20.5)
II	325 (62.4)	81 (61.4)		89 (67.9)	23 (59)
III	23 (4.4)	5 (3.8)		9 (6.9)	0 (0)
IV	52 (10)	13 (9.8)		17 (13)	4 (10.3)
Histological grade1			0.448			0.770
G1-G2	176 (33.8)	40 (30.3)		47 (35.9)	13 (33.3)
G3-G4	345 (66.2)	92 (69.7)		84 (64.1)	26 (66.7)
Size (cm)2	4.7 ± 2.9	4.1 ± 2.1	0.083	5.4 ± 3.0	4.1 ± 2.0	0.018a
R status1			0.729			0.114
R0	508 (97.5)	130 (98.5)		123 (93.9)	39 (100)
R1	13 (2.5)	2 (1.5)		8 (6.1)	0 (0)
Lymphovascular invasion1			0.785			0.484
Positive	437 (83.9)	112 (84.8)		108 (82.4)	34 (87.2)
Negative	84 (16.1)	20 (15.2)		23 (17.6)	5 (12.8)

¹Pearson’s χ² test;

²Mann-Whitney U-test.

^aP < 0.05, non-OB vs OB. EGC: Early gastric cancer; OB: Overt bleeding.

Table 3 Univariate and multivariate survival analyses for upper gastric cancer

Variable	Univariate analysis	Multivariate analysis
	P value	HR	95%CI	P value
Age1
Gender (vs male)2	0.056
OB vs non-OB2	< 0.001b	0.346	0.148-0.808	0.014a
AJCC stage3	< 0.001b	1.638	1.366-1.966	< 0.001b
AJCC T category3	< 0.001b
AJCC N category3	< 0.001b
Macroscopic (Borrmann) type2 (vs type I)	0.003b
II
III
IV
Histological type3	0.069
Size1		1.090	1.012-1.174	0.023a
R status2 (vs R0)	0.008b
R1
Lymphovascular invasion2	0.001b
(vs negative)
Positive

¹Consecutive variables;

²Unordered categorical variables;

³Ordinal categorical variables.

^aP < 0.05;

^bP < 0.01.

Table 4 Patient characteristics for middle and lower gastric cancer patients n (%)

	Middle gastric cancer			Lower gastric cancer
	Non-OB	OB	P value	Non-OB	OB	P value
Gender1			0.902			0.684
Male	29 (58)	9 (56.3)		229 (67.4)	50 (64.9)
Female	21 (42)	7 (43.8)		111 (32.6)	27 (35.1)
Age2	62.3 ± 11.2	61.3 ± 14.8	0.616	62.8 ± 11.9	62.6 ± 13.6	1.000
AJCC stage1			0.319			0.659
I-II	18 (36.0)	8 (50.0)		176 (51.8)	42 (54.5)
III-IV	32 (64.0)	8 (50.0)		164 (48.2)	35 (45.5)
T category1			0.291			0.891
T1-T2	12 (24)	6 (37.5)		134 (39.4)	31 (40.3)
T3-T4	38 (76)	10 (62.5)		206 (60.6)	46 (59.7)
Involved lymph nodes2	8.5 ± 10.6	7.1 ± 9.0	0.432	5.1 ± 7.9	4.5 ± 6.2	0.844
N category1			0.104			0.396
N0	14 (28.0)	8 (50)		137 (40.3)	27 (35.1)
N1-N3	36 (72.0)	8 (50)		203 (59.7)	50 (64.9)
Macroscopic (Borrmann) type1			0.577			0.742
EGC	7 (14.0)	3 (18.8)		76 (22.4)	12 (15.6)
I	4 (8.0)	2 (12.5)		18 (5.3)	4 (5.2)
II	29 (58.0)	7 (43.8)		207 (60.9)	51 (66.2)
III	2 (4.0)	2 (12.5)		12 (3.5)	3 (3.9)
IV	8 (16.0)	2 (12.5)		27 (7.9)	7 (9.1)
Histological grade1			0.554			0.282
G1-G2	10 (20)	5 (31.3)		119 (35.0)	22 (28.6)
G3-G4	40 (80)	11 (68.8)		221 (65)	55 (71.4)
Size (cm)2	5.0 ± 3.0	4.0 ± 2.5	0.246	4.4 ± 2.8	4.1 ± 2.1	0.745
R status1			1.000			0.559
R0	48 (96.0)	15 (93.8)		337 (99.1)	76 (98.7)
R1 + R2	2 (4.0)	1 (6.3)		3 (0.9)	1 (1.3)
Lymphovascular invasion1			0.266			0.445
Positive	39 (78.0)	15 (93.8)		290 (85.3)	63 (81.8)
Negative	11 (22.0)	1 (6.3)		50 (14.3)	14 (18.2)

¹Pearson’s χ² test;

²Mann-Whitney U-test. EGC: Early gastric cancer; OB: Overt bleeding.

Table 5 Univariate and multivariate survival analyses for lower gastric cancer

Variable	Univariate analysis	Multivariate analysis
	P value	HR	95%CI	P value
Age1		1.023	1.008-1.037	0.002
Gender (vs male)2	0.930
OB vs non-OB2	0.553
AJCC stage3	< 0.001b	1.690	1.508-1.894	< 0.001
AJCC T category3	< 0.001b
AJCC N category3	< 0.001bb
Macroscopic (Borrmann) type2 (vs type I)	< 0.001b
II
III
IV
Histological type3	0.001b
Size1
R status2 (vs R0)	0.003b
R1
Lymphovascular invasion2 (vs negative)	< 0.001b	1.687	1.160-2.455	0.006
Positive

¹Consecutive variables;

²Unordered categorical variables;

³Ordinal categorical variables;

^bP < 0.01.