Research progress and prospects of markers for liver cancer stem cells

doi:10.3748/wjg.v21.i42.12190

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Nov 14, 2015 (publication date) through Nov 26, 2024

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Nov 14, 2015; 21(42): 12190-12196
Published online Nov 14, 2015. doi: 10.3748/wjg.v21.i42.12190

Table 1 Reported major liver cancer stem cell markers

Marker	Origin	Minimum tumorigenic cells	Clinical relevant characteristics	Related literature
CD133	HuH7 cell,SMMC-7721 cell	1 × 10²-1 × 10³	With a poor prognosis;Related with invasiveness and distant metastases;Resistance to chemotherapy drugs	[14,15,17,48,59]
CD90	PLC cell,MHCC-97L,HCC tumor,blood samples of 90% patients with liver cancer	5 × 10²	Related with tumorigenic ability and metastasis of liver cancer	[23,24]
EpCAM	HuH1 cell,HuH7 cell	1 × 10³	The origin of recurrence and metastasis postoperatively;Patients with vascular metastasis and low overall survival rate when peripheral circulation exists	[31]
OV6	SMMC-7721 cell	5 × 10³	Drugs resistance;Strong metastasis and invasion	[39]
CD44¹	MHCC-LM3 cell,MHCC-97L cell	1 × 10²	Chemotherapy drug resistance;Related with portal vein metastasis in liver cancer	[41]
SP (ABCG2)	Huh7 cell,PLC/PRF/5 cell	1 × 10³	-	[46,60]

¹Co-expression of CD133+ and CD44+ cell surface markers. SP: Side population; EpCAM: Epithelial cell adhesion molecule.

Citation: Zhu CP, Wang AQ, Zhang HH, Wan XS, Yang XB, Chen SG, Zhao HT. Research progress and prospects of markers for liver cancer stem cells. World J Gastroenterol 2015; 21(42): 12190-12196
URL: https://www.wjgnet.com/1007-9327/full/v21/i42/12190.htm
DOI: https://dx.doi.org/10.3748/wjg.v21.i42.12190