Hepatitis B virus burden in developing countries

Table 1 Prevalence of hepatitis B virus infection and genotype distribution in some African countries

Countries	HBsAg-positive prevalence[4,11]	HBV genotype distribution[66,68-73,75,77]
Burkina Faso	14.5%	A: A1 southern and eastern Africa
Cameroon	10.1%	A2 South Africa
Gabon	9.5%	D: D1 and D7 northern Africa
Ghana	13.8%	E: western and central Africa
Mali	15.5%	Recombinant A/D and A/E
Mauritania	10.9%
Nigeria	13.6%
Senegal	13.8%
Zambia	6.5%
Zimbabwe	25.0%

HBsAg: Hepatitis B surface antigen; HBV: Hepatitis B virus.

Table 2 Prevalence of hepatitis B virus infection and genotype distribution in some Asian countries

Countries	HBsAg-positive prevalence[16,85-92,96,99,105-108]	HBV genotype distribution[109-118,121,123,125]
Cambodia	4.6%	A: India
		A1 India
		B: China
China	7.18%	B2 southern China
Gaza Strip	3.5%	C: China
India	3.7%	C1 southern China, India
Iraq	0.6%	C2 northern China
Jordan	1.4%	D: Arabian countries and India
Kazakhstan	3.8%	D1 Persian Gulf (Iran, Syria, Turkey), India, Pakistan D2, D3, D4, D9 India
Kuwait	3.5%
Saudi Arabia	1.5%-2.6%
Singapore	3.6%	C/D1-CD2 western China
South Korea	4.0%
United Arab Emirates	2%-7%
Yemen	5.1%

HBsAg: Hepatitis B surface antigen; HBV: Hepatitis B virus.

Table 3 Prevalence of hepatitis B virus infection and genotype distribution in some eastern European countries

Countries	HBsAg prevalence[133-138,142-145,147,148]	HBV genotype distribution[150-156,160,161]
Albania	> 9%	A: Eastern Europe (Poland,
		Czech Republic, Bulgaria,
		Hungary1)
		A2 Bulgaria
		D: Southeastern Europe (Russia, the Baltic region, Belarus, Romania, Hungary, Serbia, Croatia, Lithuania, Romania, Bulgaria)1
		D1 Bulgaria
		D2 Albania, Russia, Estonia, the Siberian and eastern part of the former USSR
Bulgaria	3.80%	D3 Serbia
Croatia	1.7%-15.8%	[D: prevalent genotype (70%-80%)]
Poland	3.91/1000001
Romania	5.59%	1A,D: equal distribution
Russia	7.6/100000
Serbia	4.4%-13%

¹Incidence/year. HBsAg: Hepatitis B surface antigen; HBV: Hepatitis B virus.

Table 4 Prevalence of hepatitis B virus infection and genotype distribution in some Latin American countries

Countries	HBsAg prevalence[166-169]	HBV genotype distribution[177,178]
Mexico, Honduras, Nicaragua, Costa Rica, Panama, Uruguay, Chile, Argentina, Peru, northern Colombia	Low prevalence (< 2%)	F: F1 Central America eastern South-America
		F2 Venezuela, Brazil
		F3 Central (Panama) and northern (Colombia and Venezuela)
Central America: Guatemala, El Salvador, Honduras, Haiti, Dominican Republic, Puerto Rico	Intermediate prevalence (> 2%, < 8%)	Latin America
		F4 Bolivia and Argentina (F genotype: prevalent)
		H: Amerindians and Mestizios in Mexico
South America: Ecuador, French Guyana, Suriname, south Brazil		A, D: Gualalajara, Jalisco, Mexico, Argentina
Northern Brazil, southern Colombia, Peru, northern Bolivia	High prevalence (> 8%)	B, C: dispersed among Latin America populations (due to Asian immigrants)

HBsAg: Hepatitis B surface antigen; HBV: Hepatitis B virus.