Colorectal cancer: Metastases to a single organ

Table 1 Hepatic metastasectomy: Large retrospective studies

Ref.	Patients, n	Median overall survival (mo)	5-yr survival	10-yr survival	20-yr survival
Rees et al[19], 2008	929		36%	23%
Choti et al[17], 2002	226	46	40%	26%
Fong et al[22], 1999	1001	42	37%	22%
Nordlinger et al[18], 1996	1568		28%
Scheele et al[20], 1995	434	40	33%	20%	17%

Table 2 Retrospective studies of patients with unresected liver metastases

Ref.	Patients without extrahepatic metastases, n	The extent of liver involvement	Median overall survival (mo)	Treatments
Yamamura et al[41], 1997 (n = 73)	67	Metastases in one lobe	13	Chemotherapy (chemotherapy did not significantly affect survival in multivariate analysis)
		Less than four metastases in both lobes	12
		More than five metastases in both lobes	6
Stangl et al[39], 1994	189	≤ 25%	11.1	No treatment
		> 25%	6.3
Chang et al[38], 1989 (n = 67)	49		15.1	Floxuridine (hepatic arterial or intravenously)
		< 25%	23.8
		25%-75%	14.8
		> 75%	7.3
Arnaud et al[40], 1984 (n = 56)	(not specified)	One lobe	17	NA
		Both lobes	8.23
Johnson et al[42], 1981	51	Solitary liver metastasis (n = 12)	18	NA
		Multiple metastases in one lobe (n = 6)	7
		Multiple metastases in both lobes (n = 33)	8

mOS: Median overall survival; NA: Not available.

Table 3 Retrospective studies including ≥ 100 patients with resectable lung metastases from colorectal cancer

Ref.	Year	n	median survival (mo)	5-yr survival rate (%)
Borasio et al[66]	2011	137	36.2	55
Hwang et al[67]	2010	125	37	48
Riquet et al[68]	2010	127	45	41
Watanabe et al[69]	2009	113	NA	68
Welter et al[70]	2007	169	47.2	39
Yedibela et al[71]	2006	153	43	37
Inoue et al[72]	2004	128	49	45
Kanemitsu et al[73]	2004	313	38	38
Pfannschmidt et al[74]	2003	167	40	32
Saito et al[75]	2002	165	NA	40
Zink et al[76]	2001	110	41	32

NA: Not available.