Copyright
©The Author(s) 2015.
World J Gastroenterol. Oct 28, 2015; 21(40): 11387-11395
Published online Oct 28, 2015. doi: 10.3748/wjg.v21.i40.11387
Published online Oct 28, 2015. doi: 10.3748/wjg.v21.i40.11387
Bio specimen | Type of biomarker | Examples of molecular markers |
Blood | Conventional protein markers | Carbohydrate antigen 19-9 (CA 19-9) |
Carcinoembryonic antigen (CEA) | ||
Novel proteins | Intercellular adhesion molecule-1 (ICAM-1) | |
Osteoprotegerin (OPG) | ||
Macrophage inhibitory cytokine-1 (MIC-1) | ||
Tissue inhibitor of metalloproteinases-1 (TIMP-1) | ||
S100 calcium-binding protein P (S100P) | ||
Mutated genes | KRAS, TP53, SMAD4, CDKN2A, KDM6A, PREX2 | |
Aberrantly methylated genes | p16, ppENK, cyclin D2, SPARC/osteonectin SOCS-1, TSLC1 | |
Micro-RNAs | miR-1290, miR-145, miR-150, miR-223, miR-636, miR-26b, miR-34a, miR-122, miR-126, miR-145, miR-150, miR-223, miR-505, miR-636, miR-885.5p. | |
Circulating tumor cells | (molecular markers not yet interrogated) | |
Cyst fluid | Mutated genes | KRAS, GNAS |
Aberrantly methylated genes | BNIP3, PTCHD2, SOX17, NXPH1 and EBF3 | |
Micro-RNAs | miR-138, miR-195, miR-204, miR-216a, miR-217, miR-218, miR-802, miR-155, miR-214, miR-26a, miR-30b, miR-31, and miR-125 | |
Tumor tissue | Novel proteins | Gelsolin, Lumican, Galectin-1 and Laminin |
Pancreatic juice | Mutated genes | KRAS, TP53 |
Aberrantly methylated genes | ADCY1, CD1D, BMP3 | |
Stool | Mutated genes | KRAS, BMP3 |
- Citation: Majumder S, Chari ST, Ahlquist DA. Molecular detection of pancreatic neoplasia: Current status and future promise. World J Gastroenterol 2015; 21(40): 11387-11395
- URL: https://www.wjgnet.com/1007-9327/full/v21/i40/11387.htm
- DOI: https://dx.doi.org/10.3748/wjg.v21.i40.11387