Prediction of the indication criteria for endoscopic resection of early gastric cancer

Table 1 Risk factors for lymph node metastasis in early gastric cancer (n = 2270) by multivariate analysis

	OR	95%CI	P value
Tumor size ≤ 30 mm vs > 30 mm	2.1	1.5-3.0	< 0.001
Depth of invasion
M vs SM1	1.6	1.0-2.4	< 0.001
M vs SM2	4.7	3.0-7.2	0.040
Lymphatic invasion	4.1	2.8-6.0	< 0.001
Vascular invasion	4.7	3.1-7.1	< 0.001

Table 2 Risk factors for lymph node metastasis in intramucosal gastric cancer (n = 1340) by univariate analysis n (%)

	Negative	Positive	P value
Gender			0.217
Male/female	843/458	29/10
Age	58.5 ± 11.8	50.6 ± 14.5	< 0.001
Size of tumor (mm, mean ± SD)	23.5 ± 15.7	37.9 ± 28.6	< 0.001
Tumor size			< 0.001
≤ 30 mm	961 (81)	18 (54)
> 30 mm	224 (19)	15 (46)
Tumor location			0.052
Upper	192 (15)	14 (36)
Middle	736 (59)	19 (48)
Lower	324 (26)	6 (16)
Lauren			< 0.001
Intestine type	634 (61)	11 (38)
Diffuse type	371 (36)	16 (55)
Mix type	33 (3)	2 (7)
Histologic type			0.715
Differentiated	799 (62)	20 (53)
Undifferentiated	498 (38)	18 (47)
Ulcer finding			0.757
Absence/presence	619/550	14/14
Lymphatic invasion			< 0.001
Absence/presence	1202/93	23/15
Vascular invasion			< 0.001
Absence/presence	1272/22	22/17
Perineural invasion			< 0.001
Absence/presence	1279/13	36/3

Table 3 Risk factors for lymph node metastasis in submucosal gastric cancer (n = 930) by univariate analysis n (%)

	Negative	Positive	P value
Gender			0.369
Male/female	497/254	119/60
Age	61.0 ± 11.3	60.2 ± 11.4	< 0.001
Size of tumor (mm, mean ± SD)	27.0 ± 14.8	36.1 ± 19.9	< 0.001
Tumor size			< 0.001
≤ 20 mm	512 (73)	94 (55)
> 20 mm	188 (27)	76 (45)
Tumor location			0.651
Upper	157 (21)	34 (20)
Middle	376 (50)	93 (52)
Lower	223 (29)	52 (28)
Lauren			0.514
Intestine type	343 (56)	69 (47)
Diffuse type	215 (35)	63 (43)
Mix type	52 (9)	16 (10)
Histologic type			0.884
Differentiated	489 (65)	113 (63)
Undifferentiated	258 (35)	66 (37)
Ulcer finding			0.115
Absence/presence	255/388	51/104
Lymphatic invasion			< 0.001
Absence/presence	526/222	47/130
Vascular invasion			< 0.001
Absence/presence	665/82	104/71
Perineural invasion			0.103
Absence/presence	693/56	157/22

Table 4 Lymph node metastasis according to the presence of ulcer, differentiation, lymphovascular invasion, and the depth of invasion in early gastric cancer patients

Ulcer	Differentiation	VI	LI	Size
				≤10 mm	> 10 mm	> 20 mm	> 30 mm
M
Ulcer negative	Differentiated	No	No	0/102	2/112	0/81	1/57
			Yes	0/5	0/2	0/1	0/5
		Yes	No	0	0	0	1/2
			Yes	0	1/2	0/0	1/2
	Undifferentiated	No	No	1/66	2/41	0/41	1/45
			Yes	0/3	0/3	0/1	0/2
		Yes	No	0	0	0	0
			Yes	0	0	0/1	3/3
Ulcer positive	Differentiated	No	No	1/59	1/104	0/67	1/47
			Yes	0/5	1/12	0/1	1/5
		Yes	No	0	0	0	0
			Yes	0/2	0/4	0/0	1/1
	Undifferentiated	No	No	0/40	0/50	1/42	0/46
			Yes	0/4	0/2	0/6	1/4
		Yes	No	0	0	0	0
			Yes	0/1	1/2	0/1	1/1
SM1
Ulcer negative	Differentiated	No	No	0/10	1/19	0/12	1/13
			Yes	0/3	0/3	1/2	0/1
		Yes	No	0	0	1/1	2/2
			Yes	0	1/3	0/0	1/3
	Undifferentiated	No	No	0/7	0/6	1/8	0/6
			Yes	0	0/2	0/0	0/1
		Yes	No	0	0	0	0
			Yes	0	0/1	0/1	2/3
Ulcer positive	Differentiated	No	No	0/14	2/24	0/19	1/13
			Yes	0/1	0/0	1/7	1/5
		Yes	No	0	0/1	0/0	0
			Yes	0	0/1	2/3	3/3
	Undifferentiated	No	No	0/6	2/12	2/7	1/6
			Yes	0/2	1/7	0/3	1/7
		Yes	No	0	0	0	1/1
			Yes	1/2	3/5	1/4	1/1
SM2
Ulcer negative	Differentiated	No	No	0/4	2/23	1/25	0/18
			Yes	0	1/12	2/5	11/27
		Yes	No	0/1	0/0	0/0	0
			Yes	0/1	1/3	0/1	6/8
	Undifferentiated	No	No	0/1	1/14	2/9	1/4
			Yes	0/2	1/1	0/2	3/7
		Yes	No	0/1	0/0	0/0	0
			Yes	0/1	0/0	5/6	1/3
Ulcer positive	Differentiated	No	No	3/16	2/33	1/31	3/31
			Yes	0/3	5/15	12/27	13/31
		Yes	No	0	0	1/3	0/3
			Yes	0/1	1/2	2/5	4/5
	Undifferentiated	No	No	0/4	2/14	1/19	4/18
			Yes	0/2	1/8	1/6	4/11
		Yes	No	0	0	0/1	1/1
			Yes	1/1	3/4	5/8	3/5