Effect of tumor necrosis factor-α antagonists on oxidative stress in patients with Crohn’s disease

Table 1 Clinical characteristics of patients n (%)

Characteristics	All patients (n = 42)
Sex
Male	30 (71)
Female	12 (29)
Age (yr), median	31.9 (17-57)
Disease duration (yr), median	6.2 (0-16)
Disease type
Ileal	11 (26)
Ileo-colonic	26 (62)
Colonic	5 (12)
Patients with concomitant medication
5-aminosalicylic acid	41 (98)
Prednisone	9 (21)
Azathioprine	7 (17)
Enteral nutrition	24 (57)
Previous segmental resection	8 (19)
Infliximab	10 (24)
Adalimumab	32 (76)

Table 2 Biochemical tests for C-reactive protein, albumin, and white blood cell count

Biochemical tests	Before	8 wk	P value
CRP (mg/dL)	2.4 ± 2.6	1.1 ± 1.6	< 0.01
Alb (g/dL)	3.4 ± 0.75	3.7 ± 0.84	NS
WBC (per μL)	7339 ± 2484	7278 ± 2532	NS

CRP: C-reactive protein; WBC: White blood cell count; Alb: Albumin; NS: Not significant.

Table 3 Correlations between d-ROM, BAP, m-OA, CDAI, serum CRP, WBC, and serum albumin in Crohn’s disease patients treated with anti-TNF-α

Oxidative markers	Clinical parameters	r	P value
d-ROM	CDAI
	Before	0.42	< 0.01
	After	0.33	0.03
	CRP
	Before	0.64	< 0.01
	After	0.53	< 0.01
	WBC
	Before	0.12	0.47
	After	0.03	0.84
	Alb
	Before	-0.33	0.03
	After	-0.38	0.01
BAP	CDAI
	Before	-0.17	0.28
	After	-0.18	0.24
	CRP
	Before	0.03	0.85
	After	0.12	0.44
	WBC
	Before	-0.04	0.79
	After	0.01	0.95
	Alb
	Before	0.24	0.13
	After	0.14	0.38
m-OA	CDAI
	Before	-0.48	< 0.01
	After	-0.42	< 0.01
	CRP
	Before	-0.63	< 0.01
	After	-0.45	< 0.01
	WBC
	Before	-0.20	0.21
	After	-0.01	0.73
	Alb
	Before	0.45	< 0.01
	After	0.47	< 0.01

TNF: Tumor necrosis factor; m-OA: Modified ratio of oxidative stress and antioxidant capacity; BAP: Biological antioxidant potential; d-ROM: Diacron-reactive oxygen metabolite; CDAI: Crohn’s disease activity index.