Clinical utility of a new endoscopic scoring system for Crohn’s disease

Table 1 Patient characteristic

n	76
Sex (M:F)	60:16
Age at diagnosis (yr)1	24 (11-71)
Age at DBE (yr)1	36 (16 -71)
Disease duration (yr)1	7.5 (0-33)
Disease location (L1:L2:L3)	16:28:32
Prior surgery	40
Disease behavior (B1:B2:B3)	27:43:6
CDAI2	106.7 ± 54.6
Medication at DBE
Infliximab	29
Azathioprine	18
Elemental diet	61
5-ASA	63
No medication	4

¹median (range);

²mean ± SD. Location: L1, colorectum; L2, colorectum and small intestine; L3, small intestine; Behaviour: B1, non-structuring non-penetrating B2, stricturing B3, penetrating; CDAI: Crohn's disease activity index; ASA: Aminosalicylic acid; DBE: Double balloon enteroscopy.

Table 2 Comparison of clinical variables between the low and high modified Simple Endoscopic Score for Crohn’s disease groups

mSES-CD	Low (< 4)	High (≥4)	P value
Number	16	60
Sex (Male:Female)	15:1	45:15	0.092
Mean age at diagnosis (yr)	27.2 ± 8.9	25.8 ± 11.0	0.648
Mean disease duration (yr)	13.1 ± 8.0	9.0 ± 8.8	0.097
Prior surgery (yes/no)	10:6	30:30	0.374
Infliximab (yes/no)	8:8	21:39	0.272
Azathioprine (yes/no)	2:14	16:44	0.200
Elemental diet (yes/no)	14:2	47:13	0.335
5-ASA (yes/no)	15:1	48:12	0.180
CDAI	90.0 ± 55.4	111.0 ± 54.1	0.186
CRP (mg/dL)	0.16 ± 0.21	1.13 ± 1.57	< 0.001
Albumin (g/dL)	4.01 ± 0.82	3.47 ± 0.72	0.010

ASA: Aminosalicylic acid; CDAI: Crohn's disease activity Index; CRP: C-reactive protein.

Table 3 Univariate and multivariate analyses for surgery-free survival (n = 76)

		Univariate analyses			Multivariate analyses
		HR	95%CI	P value	HR	95%CI	P value
mSES-CD	≥ 4	7.59	1.03-56.0	0.047	9.38	1.20-73.5	0.033
SES-CD	≥ 4	1.34	0.60-3.02	0.477		-
Sex	Male	0.97	0.39-2.42	0.942		-
Age at diagnosis	< 20	1.07	0.48-2.35	0.876		-
Disease duration	≥ 10	2.21	0.98-4.81	0.056	2.75	1.18-6.45	0.020
Prior surgery	Yes	1.52	0.69-3.34	0.303		-
Albumin	< 4	1.53	0.64-3.63	0.340		-
Platelet	≥ 410 × 104	1.91	0.76-4.77	0.166		-
CRP	≥ 0.3	1.56	0.72-3.38	0.259		-
WBC	≥ 8500	1.42	0.42-4.72	0.572		-
CDAI	≥ 150	1.85	0.80-4.30	0.151		-
Infliximab	Yes	0.34	0.13-0.90	0.029	0.31	0.12-0.83	0.019
5-ASA	Yes	1.12	0.42-2.97	0.822		-
Elemental diet	Yes	1.41	0.48-4.10	0.530		-
Azathioprine	Yes	0.66	0.25-1.76	0.408		-
Disease location	Colorectum	0.38	0.11-1.27	0.114		-
	Colorectum + Small intestine	2.17	1.00-4.69	0.050		Excluded
	Small intestine	0.91	0.41-2.02	0.824		-

CRP: C-reactive protein; WBC: White blood cell; CDAI: Crohn's disease activity Index; ASA: Aminosalicylic acid; mSES-CD: Modified Simple Endoscopic Score for Crohn’s disease.