Liver reserve function assessment by acoustic radiation force impulse imaging

Table 1 Child-Pugh scoring criteria

Indexes	Score
	1 score	2 score	3 score
Hepatic encephalopathy (class)	Without	Mild	Occasional lethargy
Ascites	Without	Little/controllable by diuretics	A lot
T-Bil (μmol/L)	< 34	34-51	> 51
ALB (g/L)	> 35	28-35	< 28
Prolonged prothrombin time (s)	< 4	4-6	> 6

Child-Pugh class A: 5-6 score; Child-Pugh class B: 7-9 score; Child-Pugh class C: ≥ 10 score. T-Bil: Total bilirubin; ALB: Albumin.

Table 2 Biochemical examination results of patients

Indexes	mean ± SD	Media, n	Minimum value	Maximum value
ALT (U/L)	58.77 ± 51.13	57.81	13.74	127.28
AST (U/L)	64.21 ± 60.33	60.03	15.62	153.10
ALB (g/L)	38.19 ± 10.14	37.31	10.01	67.43
T-Bil (μmol/L)	26.28 ± 20.61	22.33	4.72	126.74

ALT: Aminotransferase; AST: Aspartate aminotransferase; ALB: Serum albumin; T-Bil: Total bilirubin.

Table 3 Average values of liver stiffness, indocyanine green-R15 and indocyanine green-K in each group, based on indocyanine green-R15 grouping

Groups	Number of cases	LS average value (m/s)	ICG-R15 (%)	ICG-K (L/min)
< 10%	57	1.59 ± 0.32	8.99 ± 2.15	0.19 ± 0.04
10%-20%	16	2.19 ± 0.27a	13.54 ± 2.12	0.16 ± 0.05
> 20%	3	2.53 ± 0.29 a	17.32 ± 0.73	0.11 ± 0.07

^aP < 0.05, vs the < 10% group. LS: Liver stiffness; ICG: Indocyanine green.

Table 4 Different average liver stiffness, indocyanine green-R15 and indocyanine green-K values according to different Child-Pugh scores

CP class	Cases	LS average value (m/s)	ICG-R15 (%)	ICG-K (L/min)
Class A (5-6)	48	1.57 ± 0.34	8.90 ± 3.67	0.23 ± 0.04
Class B (7-9)	15	1.86 ± 0.27a	11.38 ± 2.71	0.19 ± 0.05
Class C (10-15)	13	2.47 ± 0.33ac	14.44 ± 3.58	0.14 ± 0.07

^aP < 0.05, vs class A;

^cP < 0.05, vs the class B. CP: Child-Pugh; LS: Liver stiffness; ICG: Indocyanine green.

Table 5 Correlations between liver stiffness and liver function index

Index	r	P value
ICG-R15	0.862	0.000
ICG-K	-0.708	0.000
CP score	0.772	0.000
AST	0.318	0.024
ALT	0.493	0.001
ALB	-0.511	0.001
T-Bil	0.225	0.017

ICG: Indocyanine green; CP: Child-Pugh; ALT: Aminotransferase; AST: Aspartate aminotransferase; ALB: Serum albumin; T-Bil: Total bilirubin.