Magnifying narrow-band imaging endoscopy is superior in diagnosis of early gastric cancer

Table 1 Clinical characteristics of eligible patients with gastric lesions

Characteristic	Number
Patients	3616
Gender (male/female)	1910/1706
Gastric mucosal lesions	3675
Location of lesions
Upper third	182 (5.0)
Middle third	206 (5.6)
Lower third	3287 (89.4)
Pathological diagnosis
Chronic gastritis with/without intestinal metaplasia	2787 (75.8)
Low-grade neoplasia (C3)1	631 (17.2)
EGC (including C4 and C5)1	257 (7.0)

¹According to revised Vienna classification[14].

Table 2 Comparison of the diagnostic value for early gastric cancer among different modalities of endoscopy

Procedure	Number	Pathological diagnosis		Sensitivity	Specificity	Positive predictive value	Negative predictive value	Accuracy
		0	1	(95%CI)	(95%CI)	(95%CI)	(95%CI)	(95%CI)
HD-WLE
0	3461	3387	74	71.2%	99.1%	85.5%	97.9%	97.1%
1	214	31	183	(65.4-76.4)	(98.7-99.4)	(80.2-89.6)	(97.3-98.3)	(96.6-97.6)
ME
0	3424	3376	48	81.3%a	98.8%	83.3%	98.6%	97.6%a
1	251	42	209	(76.1-85.6)	(98.3-99.1)	(78.2-87.4)	(98.2-98.9)	(97.0-98.0)
ME-NBI
0	3402	3369	33	87.2%a	98.6%	82.1%	99.0%	97.8%a
1	273	49	224	(82.5-90.1)	(98.1-98.9)	(77.1-86.2)	(98.6-99.3)	(97.2-98.2)

^aP < 0.05 vs WLE. 0: Noncancerous lesions (chronic gastritis, chronic gastritis with intestinal metaplasia and low-grade neoplasia); 1: Cancerous lesions (EGC including high-grade neoplasia); HD-WLE: High definition white light endoscopy; ME: Magnifying endoscopy; ME-NBI: Magnifying narrow-band imaging endoscopy.