Genetic association of apolipoprotein E polymorphisms with inflammatory bowel disease

doi:10.3748/wjg.v21.i3.897

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Jan 21, 2015; 21(3): 897-904
Published online Jan 21, 2015. doi: 10.3748/wjg.v21.i3.897

Table 1 Apolipoprotein E allele frequencies n (%)

Allele	IBD (n = 356)	Control (n = 400)	P value	RR	EF/PF
ε3	293 (82.30)	383 (95.75)	< 0.01	0.206	0.549
ε4	36 (10.11)	17 (4.25)	< 0.01	2.531	0.411
ε2	27 (7.59)	0 (0)	< 0.01	-	-

EF: Etiologic fraction; IBD: Inflammatory bowel disease; PF: Preventive fraction; RR: Relative risk; n: Number of alleles.

Table 2 Apolipoprotein E genotype frequencies n (%)

Genotype	IBD (n = 178)	Control (n = 200)	P value	RR	EF/PF
ε3/ε3	118 (66.29)	183 (91.5)	< 0.01	0.183	0.637
ε3/ε4	25 (14.05)	17 (8.5)	0.10	1.759	0.256
ε2/ε3	24 (13.48)	0 (0)	< 0.01	-	-
ε2/ε4	11 (6.18)	0 (0)	< 0.01	-	-
ε2/ε2	0 (0)	0 (0)	-	-	-
ε4/ε4	0 (0)	0 (0)	-	-	-

EF: Etiologic fraction; IBD: Inflammatory bowel disease; PF: Preventive fraction; RR: Relative risk; n: Number of alleles.

Table 3 Gender comparison of apolipoprotein E genotypes and alleles n (%)

Genotype/allele	Male (n = 90)	Female (n = 88)	P value
ε3/ε3	66 (73.33)	52 (59.09)	< 0.05¹
ε3/ε4	11 (12.22)	14 (15.91)	0.52
ε2/ε3	9 (10.00)	15 (17.05)	0.19
ε2/ε4	4 (4.45)	7 (7.95)	0.36
ε3	152 (84.45)	133 (75.57)	0.04¹
ε4	13 (7.22)	21 (11.93)	0.15
ε2	15 (8.33)	22 (12.50)	0.22

¹Statistically significant.

Table 4 Apolipoprotein E genotypes and alleles in Crohn’s disease and ulcerative colitis n (%)

Genotype/allele	CD (n = 94)	UC (n = 84)
ε3/ε3	63 (67.02¹)	55 (65.48¹)
ε3/ε4	10 (10.64²)	15 (17.86¹³)
ε2/ε3	14 (14.89¹)	10 (11.90¹)
ε2/ε4	7 (7.45¹)	4 (4.76¹)
ε3	150 (79.79¹)	135 (80.36¹)
ε4	21 (11.17¹)	19 (11.31¹)
ε2	17 (9.04¹)	14 (8.33¹)

¹P < 0.05 vs controls;

³Relative risk = 2.34,

²Relative risk = 1.28. CD: Crohn's disease; UC: Ulcerative colitis.

Table 5 Apolipoprotein E genotypes and alleles in familial and sporadic inflammatory bowel disease n (%)

Genotype/allele	Familial (n = 20)	Sporadic (n = 158)	P value
ε3/ε3	14 (70.00)	104 (65.82)	0.80
ε3/ε4	4 (20.00)	21 (13.30)	0.49
ε2/ε3	2 (10.00)	22 (13.92)	1.00
ε2/ε4	0 (0)	11 (6.96)	0.61
ε3	34 (85.00)	251 (79.43)	0.52
ε4	4 (10.00)	32 (10.13)	1.00
ε2	2 (5.00)	33 (10.44)	0.40

Citation: Al-Meghaiseeb ES, Al-Otaibi MM, Al-Robayan A, Al-Amro R, Al-Malki AS, Arfin M, Al-Asmari AK. Genetic association of apolipoprotein E polymorphisms with inflammatory bowel disease. World J Gastroenterol 2015; 21(3): 897-904
URL: https://www.wjgnet.com/1007-9327/full/v21/i3/897.htm
DOI: https://dx.doi.org/10.3748/wjg.v21.i3.897