Simeprevir with peginterferon and ribavirin induced interstitial pneumonitis: First case report

Table 1 Patient’s laboratory findings prior to receiving treatment

Parameters	Value
WBC	5600/μL
RBC	481 × 104/μL
Hb	14.1 g/dL
Plt	15.2 × 104/μL
PT-INR	1.17
AST	63 IU/L
ALT	48 IU/L
TP	7.6 g/dL
Alb	3.7 g/dL
TBIL	1.3 mg/dL
ALP	554 IU/L
γ-GTP	27 IU/L
CRP	< 0.10 mg/dL
LDH	285 U/L
UA	4.6 mg/dL
BUN	5.8 mg/dL
Cr	0.7 mg/dL
Na	141 mEq/L
K	4.2 mEq/L
HBsAg	(-)
HCVAb	(+)
HCV-RNA	5.6 LogIU/mL
Genotype	1B

WBC: White blood cells; RBC: Red blood cells; Plt: Platelets; PT: Prothrombin time; AST: Aspartate aminotransferase; ALT: Alanine aminotransferase; TP: Total protein; Alb: Albumin; TBIL: Total bilirubin; ALP: Alkaline phosphatase; γ-GTP: Gamma glutamyl transpeptidase; CRP: C-reactive protein; LDH: Lactate dehydrogenase; UA: Uric acid; BUN: Blood urea nitrogen; Cr: Creatinine; Na: Natrium; K: Potasium; HBsAg: Hepatitis B surface antigen; HCV: Hepatitis C virus antibody; HCV-RNA: Hepatitis C virus ribonucleic acid.

Table 2 Post medical history and complication (interstitial pneumonitis)

	Positive	Negative
Incidence	11	113
Incidence rate	0.026%	0.27%
Dead	1	12
Dead/incidence	9.1%	10.6%

Japanese Welfare Ministry report include an interstitial pneumonitis incidence number. Total estimated number of patients was 42600 and total an interstitial pneumonitis incidence number was 124 (0.29%).