Viral hepatitis prevalence in patients with active and latent tuberculosis

Table 1 Prevalence of hepatitis B virus and hepatitis C virus infection in tuberculosis patients in other studies n (%)

Study (country)	Study population	Number of patients	HBsAg	HBsAg or anti-HBc	Anti-HCV
Kuniholm et al[14] (Georgia)	All active TB patients	300	13 (4.3)	27 (9)	36 (12)
Blal et al[15] (Brazil)	All active TB patients	209	6 (2.8)	56 (26.8)	-
Sirinak et al[16] (Thailand)	HIV infected active TB patients	849	70 (9)	-	237 (31)
Aires et al[17] (Brazil)	All active TB patients	402	13 (3.2)	103 (25.6)	-

HBsAg: Hepatitis B surface antigen; HCV: Hepatitis C virus; HBc: Hepatitis B core; TB: Tuberculosis.

Table 2 Demographic and Serological data of patients n (%)

Characteristic	Patients
	Total	HBV/HCV Negative	HBsAg	Isolated Anti-HBc (IgG)	HCV (IgG)
Female	209 (48.7)	173 (40.3)	4 (0.9)	31 (7.2)	1 (0.2)
Male	220 (51.3)	177 (41.3)	7 (1.6)	30 (7.0)	6 (1.4)
Age (yr)
18-35	155 (36.1)	132 (30.8)	0 (0.0)	21 (4.9)	2 (0.5)
36-53	133 (31.0)	106 (24.7)	7 (1.6)	16 (3.7)	4 (0.9)
54-71	88 (20.5)	67 (15.6)	3 (0.7)	17 (4.0)	1 (0.2)
72-90	51 (11.9)	43 (10.0)	1 (0.2)	7 (1.6)	0 (0.0)
> 90	2 (0.5)	2 (0.5)	0 (0.0)	0 (0.0)	0 (0.0)
Ethinicity
Indian Subcontinent	152 (35.4)	132 (30.8)	1 (0.2)	18 (4.2)	1 (0.2)
Black African (Sub Saharan)	104 (24.2)	73 (17.0)	6 (1.4)	23 (5.4)	2 (0.5)
Black Caribbean	21 (4.9)	17 (4.0)	0 (0.0)	4 (0.9)	0 (0.0)
North African	25 (5.8)	20 (4.7)	0 (0.0)	5 (1.2)	0 (0.0)
South East Asia	34 (7.9)	26 (6.1)	3 (0.7)	5 (1.2)	0 (0.0)
White all other (European/American/Australian)	46 (10.7)	38 (8.9)	1 (0.02)	5 (1.2)	2 (0.5)
White South American	15 (3.5)	15 (3.5)	0 (0.0)	0 (0.0)	0 (0.0)
White UK	32 (7.5)	29 (6.8)	0 (0.0)	1 (0.02)	2 (0.5)
Total	429	350 (81.6)	11 (2.6)	61 (14.2)	7 (1.6)

HBsAg: Hepatitis B surface antigen; HBV: Hepatitis B virus; HCV: Hepatitis C virus; HBc: Hepatitis B core.

Table 3 Prevalence of hepatitis B virus and hepatitis C virus infection in active TB disease vs latent tuberculosis infection patients n (%)

HBV/HCV infection	Patients		P value (Fisher’s exact test)
	Active	Latent
HBsAg/HCV Ab both negative	221 (81.9)	129 (81.1)	0.9
HBsAg or HCV Ab positive	49 (18.1)	30 (18.9)
HCV (IgG) positive	6 (2.2)	1 (0.6)	0.27
Anti-HBc (IgG) positive	43 (12.2)	29 (17.6)	0.59
Of these: HBsAg positive	> 10 (23.2)	> 1 (3.4)	> 0.04

HBsAg: Hepatitis B surface antigen; HCV: Hepatitis C virus; HBc: Hepatitis B core.