Downregulation of KIF1B mRNA in hepatocellular carcinoma tissues correlates with poor prognosis

Table 1 Kinesin family member 1B expression in cancer and paracarcinomatous tissues according to clinicopathologic features in 68 patients with hepatocellular carcinoma

Clinicopathologic feature	n	KIF1B protein, relative units			KIF1B mRNA, relative units
		HCC tissue	PC tissue	HCC/PC	HCC tissue	PC tissue	HCC/PC
Age (yr)
≥ 50	54	2.59 ± 0.53	2.50 ± 0.43	1.19 ± 0.10	1.44 ± 0.24	1.49 ± 0.23	1.01 ± 0.05
< 50	14	2.63 ± 0.92	2.26 ± 0.80	1.31 ± 0.63	1.48 ± 0.30	1.44 ± 0.26	1.07 ± 0.35
Sex
Male	57	2.62 ± 0.88	2.39 ± 0.90	1.27 ± 0.63	1.49 ± 0.29	1.48 ± 0.29	1.05 ± 0.31
Female	11	2.20 ± 0.70	2.30 ± 0.97	1.16 ± 0.63	1.39 ± 0.28	1.50 ± 0.26	0.98 ± 0.37
Child classification
A	54	2.59 ± 0.91	2.50 ± 0.89	1.19 ± 0.63	1.44 ± 0.29	1.49 ± 0.28	1.01 ± 0.32
B	14	2.40 ± 0.64	1.91 ± 0.85	1.4 8± 0.60	1.58 ± 0.27	1.45 ± 0.28	1.13 ± 0.27
Hepatitis B virus
Positive	55	2.55 ± 0.90	2.43 ± 0.93	1.28 ± 0.62	1.45 ± 0.28	1.48 ± 0.28	1.02 ± 0.30
Negative	13	2.59 ± 0.70	2.16 ± 0.84	1.38 ± 0.65	1.58 ± 0.34	1.50 ± 0.28	1.10 ± 0.37
Differentiation
Well	25	2.53 ± 0.95	2.22 ± 0.86	1.31 ± 0.68	1.54 ± 0.28	1.46 ± 0.30	1.11 ± 0.33
Moderately	32	2.52 ± 0.76	2.47 ± 0.98	1.20 ± 0.58	1.43 ± 0.28	1.49 ± 0.27	0.99 ± 0.30
Poorly	11	2.69 ± 0.90	2.45 ± 0.77	1.27 ± 0.66	1.42 ± 0.32	1.51 ± 0.28	0.98 ± 0.30
Tumor size (cm)
> 3	48	2.56 ± 0.85	2.42 ± 0.91	1.24 ± 0.64	1.46 ± 0.31	1.47 ± 0.27	1.03 ± 0.32
≤ 3	20	2.55 ± 0.90	2.27 ± 0.93	1.28 ± 0.63	1.49 ± 0.23	1.51 ± 0.31	1.05 ± 0.31
Tumor nodule
Solitary	45	2.57 ± 0.91	2.35 ± 0.93	1.27 ± 0.64	1.50 ± 0.28	1.48 ± 0.29	1.06 ± 0.31
Multiple	23	2.52 ± 0.77	2.44 ± 0.87	1.21 ± 0.62	1.42 ± 0.31	1.48 ± 0.27	1.00 ± 0.32
Vein invasion
Positive	22	2.30 ± 0.82	2.33 ± 0.97	1.21 ± 0.60	1.41 ± 0.25	1.50 ± 0.31	0.89 ± 0.29
Negative	46	2.77 ± 0.84a	2.40 ± 0.89	1.27 ± 0.65	1.50 ± 0.30	1.47 ± 0.27	1.11 ± 0.33b
Recurrence status
Yes	34	2.31 ± 0.92	2.59 ± 0.93	1.14 ± 0.63	1.42 ± 0.27	1.55 ± 0.31	0.96 ± 0.31
No	34	2.80 ± 0.80c	2.17 ± 0.85	1.36 ± 0.61	1.52 ± 0.30	1.42 ± 0.24	1.11 ± 0.29c

^aP < 0.05,

^bP < 0.01 vs positive vein invasion;

^cP < 0.05 vs recurrence. KIF1B: Kinesin family member 1B; PC: Paracarcinomatous; HCC: Hepatocellular carcinoma.