Effect of oral mesalamine on inflammatory response in acute uncomplicated diverticulitis

Table 1 Baseline

	Study patients	Control patients	P value
	(n = 20)	(n = 30)
Age (yr)1	59.9 ± 15.7	66.5 ± 15.4	0.15
Sex (F)2	12 (60.0)	19 (63.3)	0.81
BMI (kg/m²)1	24.8 ± 3.8	28.9 ± 5.8	0.01
Arterial hypertension2	11 (55)	13 (43.3)	0.42
Type 2 diabetes mellitus2	1 (5)	5 (16.7)	0.21
Recurrent episode2	5 (25)	1 (3.4)	0.02
Hinchey IB2	5 (25)	2 (6.7)	0.07
Time to admission (d)1	2.3 ± 2.1	2.3 ± 2	0.99
CRP (mg/dL)3	6 ± 4.6	6 ± 6.3	0.41
WBC (109/L)1	12.5 ± 3.6	13 ± 4	0.62
Neutrophiles (109/L)1	9.6 ± 3.1	10.4 ± 4.2	0.45
Pain (NRS score)3	3.9 ± 2.8	4.5 ± 2.4	0.55

¹Data as mean ± SD, t-test;

²Data as n (%), χ² test;

³Data as mean ± SD, Mann Whitney test.

Table 2 Clinical outcomes

	Study group		Control group		P value1
	(n = 20)		(n = 30)
	mean ± SD	Median (range)	mean ± SD	Median (range)
Time before recovery of bowel function (d)	1.9 ± 1.1	1.5 (1-4)	2.4 ± 1.7	3 (0-7)	0.29
Time before resumption of food intake (d)	1.7 ± 0.9	1 (1-4)	3.1 ± 1.7	3 (1-5)	< 0.001
Length of in-hospital stay (d)	4.7 ± 0.9	5 (3-6)	6 ± 2.1	5.5 (4-12)	0.03

¹Mann-Whitney test.

Table 3 Pain and analgesics consumption n (%)

		Study patients		Control patients		P value
		(n = 20)		(n = 30)
		Median (range)	mean ± SD	Median (range)	mean ± SD
Pain (NRS score)	Day 1	2 (0-7)	2.4 ± 2.1	2 (0-8)	1.9 ± 2.1	0.411
	Day 2	1.5 (0-8)	1.9 ± 2.3	0 (0-4)	0.9 ± 1.2	0.141
	Day 3	0 (0-3)	1.1 ± 1.4	0 (0-5)	0.4 ± 1.1	0.051
Analgesy	Day 1	11 (55)		22 (73.3)		0.182
	Day 2	13 (65)		19 (63.3)		0.902
	Day 3	7 (35)		14 (46.7)		0.412

¹Mann-Whitney test;

²Date is χ² test. Analgesy represents the proportion of patients assuming pain medications.